2022 ICD-10-CM Code I48.21

Permanent atrial fibrillation

Version 2021

Valid for Submission

ICD-10:I48.21
Short Description:Permanent atrial fibrillation
Long Description:Permanent atrial fibrillation

Code Classification

  • Diseases of the circulatory system (I00–I99)
    • Other forms of heart disease (I30-I5A)
      • Atrial fibrillation and flutter (I48)

I48.21 is a billable diagnosis code used to specify a medical diagnosis of permanent atrial fibrillation. The code I48.21 is valid during the fiscal year 2022 from October 01, 2021 through September 30, 2022 for the submission of HIPAA-covered transactions.

The ICD-10-CM code I48.21 might also be used to specify conditions or terms like permanent atrial fibrillation.

The code I48.21 is linked to some Quality Measures as part of Medicare's Quality Payment Program (QPP). When this code is used as part of a patient's medical record the following Quality Measures might apply: Atrial Fibrillation And Atrial Flutter: Chronic Anticoagulation Therapy.

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code I48.21 are found in the index:

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

Replacement Code

I4821 replaces the following previously assigned ICD-10 code(s):

Quality Payment Program Measures

When code I48.21 is part of the patient's diagnoses the following Quality Measures apply and affect reimbursement. The objective of Medicare's Quality Measures is to improve patient care by making it more: effective, safe, efficient, patient-centered and equitable.

Quality Measure Description Quality Domain Measure Type High Priority Submission Methods
Atrial Fibrillation and Atrial Flutter: Chronic Anticoagulation TherapyPercentage of patients aged 18 years and older with nonvalvular atrial fibrillation (AF) or atrial flutter who were prescribed warfarin OR another FDA-approved oral anticoagulant drug for the prevention of thromboembolism during the measurement period.Effective Clinical CareProcessNOClaims, Registry

Information for Patients


Atrial Fibrillation

An arrhythmia is a problem with the speed or rhythm of the heartbeat. Atrial fibrillation (AF) is the most common type of arrhythmia. The cause is a disorder in the heart's electrical system.

Often, people who have AF may not even feel symptoms. But you may feel

AF can lead to an increased risk of stroke. In many patients, it can also cause chest pain, heart attack, or heart failure.

Doctors diagnose AF using family and medical history, a physical exam, and a test called an electrocardiogram (EKG), which looks at the electrical waves your heart makes. Treatments include medicines and procedures to restore normal rhythm.

NIH: National Heart, Lung, and Blood Institute


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020