2024 ICD-10-CM Diagnosis Code A00.0

Cholera due to Vibrio cholerae 01, biovar cholerae

ICD-10-CM Code:
ICD-10 Code for:
Cholera due to Vibrio cholerae 01, biovar cholerae
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Certain infectious and parasitic diseases
    • Intestinal infectious diseases
      • Cholera

A00.0 is a billable diagnosis code used to specify a medical diagnosis of cholera due to vibrio cholerae 01, biovar cholerae. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Cholera
  • Cholera due to Vibrio cholerae O1 Classical biotype
  • Intestinal infection due to Vibrio cholerae O1

Clinical Classification

Clinical CategoryCCSR Category CodeInpatient Default CCSROutpatient Default CCSR
Bacterial infectionsINF003N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.
Intestinal infectionDIG001Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Clinical Information

  • Cholera

    an acute diarrheal disease endemic in india and southeast asia whose causative agent is vibrio cholerae. this condition can lead to severe dehydration in a matter of hours unless quickly treated.
  • Cholera Morbus

    an old term that is no longer used in the scientific literature. cholera morbus refers to acute gastroenteritis occurring in summer or autumn; characterized by severe cramps, diarrhea, and vomiting.
  • Cholera Toxin

    an enterotoxin from vibrio cholerae. it consists of two major protomers, the heavy (h) or a subunit and the b protomer which consists of 5 light (l) or b subunits. the catalytic a subunit is proteolytically cleaved into fragments a1 and a2. the a1 fragment is a mono(adp-ribose) transferase. the b protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the a1 fragment. the a1 catalyzed transfer of adp-ribose to the alpha subunits of heterotrimeric g proteins activates the production of cyclic amp. increased levels of cyclic amp are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
  • Cholera Vaccines

    vaccines or candidate vaccines used to prevent infection with vibrio cholerae. the original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.
  • Classical Swine Fever

    an acute, highly contagious disease affecting swine of all ages and caused by the classical swine fever virus. it has a sudden onset with high morbidity and mortality.
  • Classical Swine Fever Virus

    a species of the pestivirus genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
  • Gastrointestinal Diseases

    diseases in any segment of the gastrointestinal tract from esophagus to rectum.
  • Vipoma

    a tumor that secretes vasoactive intestinal peptide, a neuropeptide that causes vasodilation; relaxation of smooth muscles; watery diarrhea; hypokalemia; and hypochlorhydria. vipomas, derived from the pancreatic islet cells, generally are malignant and can secrete other hormones. in most cases, vipomas are located in the pancreas but can be found in extrapancreatic sites.
  • Vibrio cholerae

    the etiologic agent of cholera.
  • Gastroenteritis

    inflammation of any segment of the gastrointestinal tract from esophagus to rectum. causes of gastroenteritis are many including genetic, infection, hypersensitivity, drug effects, and cancer.
  • Pestivirus

    a genus of flaviviridae, also known as mucosal disease virus group, which is not arthropod-borne. transmission is by direct and indirect contact, and by transplacental and congenital transmission. species include border disease virus, bovine viral diarrhea virus (diarrhea virus, bovine viral), and classical swine fever virus.
  • Cholera

    an acute diarrheal illness caused by consuming water or food contaminated by the bacterium vibrio cholerae. adequate rehydration is key to surviving this illness.
  • Cholera Toxin

    secreted by vibrio cholerae, cholera toxin is a natural bacterial enterotoxin consisting of major components heavy a- and light b peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. b peptide anchors the protein to epithelia; a peptide enters the cytoplasm and activates adenylate cyclase. due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (nci04)
  • Cholera Toxin B Subunit IgG Antibody Measurement|CTBIGGAB|Cholera Toxin B Subunit IgG Antibody|Cholera Toxin B Subunit IgG Antibody

    the determination of the amount of cholera toxin b subunit igg antibody present in a sample.

    the approximately 55 kda, receptor binding b subunit of the cholera toxin and the virulence factor for vibrio cholerae.
  • Salmonella enterica Serotype choleraesuis var. decatur|SALMONELLA CHOLERAESUIS VAR. DECATUR|Salmonella decatur

    a gram-negative, rod-shaped serotype of the bacteria genus salmonella, species salmonella enterica, subspecies enterica. salmonella decatur, a rare human pathogen, was formerly classified as serotype choleraesuis variant decatur.
  • Salmonella Serotype Choleraesuis|SALMONELLA SEROTYPE CHOLERAESUIS|Salmonella enterica subsp. enterica serovar Choleraesuis

    any bacterial organism that can be assigned to the genus salmonella with serotype choleraesuis.
  • Vibrio cholerae DNA Measurement|VCHDNA|Vibrio cholerae DNA|Vibrio cholerae DNA

    the determination of the amount of vibrio cholerae dna present in a sample.
  • Vibrio cholerae, Vibrio parahaemolyticus, and/or Vibrio vulnificus DNA Measurement|C166008|V. chol/parahaemolyticus/vulnificus DNA|V. chol/parahaemolyticus/vulnificus DNA|Vibrio cholerae/parahaemolyticus/vulnificus DNA

    the determination of the amount of vibrio cholerae, vibrio parahaemolyticus, and/or vibrio vulnificus dna present in a sample.
  • Vibrio cholerae|VIBRIO CHOLERAE|Vibrio comma|Vibrio comma

    a species of facultatively anaerobic, gram negative, curved rod shaped bacteria assigned to the phylum proteobacteria. this species is motile, oxidase and lipase positive, can use a wide variety of sugars as carbon sources, does not require salt for growth, and produces cholera toxin. v. cholerae is the causative agent of cholera.
  • Vibrio mimicus|Sucrose Negative Vibrio cholerae|VIBRIO MIMICUS

    a species of facultatively anaerobic, gram negative, curved rod shaped bacteria assigned to the phylum proteobacteria. this species is motile, oxidase positive, lipase negative, hemolytic, cannot use sucrose as a carbon source and does not require salt for growth. v. mimicus is a found in marine and fresh water environments and is a pathogen that causes gastroenteritis.
  • WDHA Syndrome|Islet Cell WDHA Syndrome|Pancreatic Cholera|Pancreatic WDHA Syndrome|Verner Morrison Syndrome|WDHH|Watery Diarrhea Syndrome|Watery Diarrhea with Hypokalemic Alkalosis|Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome

    a rare syndrome characterized by severe watery diarrhea, hypokalemia, and achlorhydria. it is caused by the oversecretion of vasoactive intestinal peptide from the pancreatic islet cells.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Classical cholera

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert A00.0 to ICD-9-CM

  • ICD-9-CM Code: 001.0 - Cholera d/t vib cholerae

Patient Education


Cholera is a bacterial infection that causes diarrhea. The cholera bacterium is usually found in water or food that has been contaminated by feces (poop). Cholera is rare in the US. You may get it if you travel to parts of the world with poor water and sewage treatment. Outbreaks can also happen after disasters. The disease is not likely to spread directly from person to person.

Cholera infections are often mild. Some people don't have any symptoms. If you do get symptoms, they usually start 2 to 3 days after infection. The most common symptom is watery diarrhea.

In some cases, the infection can be severe, causing lots of watery diarrhea, vomiting, and leg cramps. Because you quickly lose body fluids, you are at risk for dehydration and shock. Without treatment, you could die within hours. If you think that you might have cholera, you should get medical care right away.

Doctors diagnose cholera with a stool sample or rectal swab. Treatment is the replacement of the fluid and salts that you lost through the diarrhea. This is usually with a rehydration solution that you drink. People with severe cases may need an I.V. to replace the fluids. Some of them may also need antibiotics. Most people who get fluid replacement right away will recover.

There are vaccines to prevent cholera. One of them is available for adults in the U.S. Very few Americans need it, because most people do not visit areas that have an active cholera outbreak.

There are also simple steps you can take to help to prevent cholera infection:

  • Use only bottled or purified water for drinking, washing dishes, making ice cubes, and brushing your teeth
  • If you do use tap water, boil it or use iodine tablets
  • Wash your hands often with soap and clean water
  • Make sure that the cooked food you eat is fully cooked and served hot
  • Avoid unwashed or unpeeled raw fruits and vegetables

Centers for Disease Control and Prevention

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.