2027 ICD-10-CM Diagnosis Code M04Autoinflammatory syndromes

ICD-10-CM Codes›M00–M99›M04›M04

ICD-10-CM M04
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

M04 is a non-billable ICD-10-CM category code for autoinflammatory syndromes, so it cannot be submitted on claims. Use a more specific code from this category instead, such as M04.1, M04.2, M04.3, and M04.8.

Code Identity

ICD-10-CM Code
M04
Billable Status
No — Non-Billable Category
Code Describes
Autoinflammatory syndromes
Short Description
Autoinflammatory syndromes
Same as the full description in the CMS dataset.
Chapter
M04
Autoinflammatory syndromes

Code Classification

ChapterM00–M99Diseases of the musculoskeletal system and connective tissue
SectionM04Autoinflammatory syndromes
CategoryM04Autoinflammatory syndromes
This CodeM04Autoinflammatory syndromes

Specific Coding for Autoinflammatory syndromesOverview

Non-specific codes like M04 require more characters. Use one of these billable codes instead:

  • Use M04.1 for Periodic fever syndromes

  • Use M04.2 for Cryopyrin-associated periodic syndromes

  • Use M04.3 for VEXAS syndrome

  • Use M04.8 for Other autoinflammatory syndromes

  • Use M04.9 for Autoinflammatory syndrome, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to M04: its own notes plus those printed at block M00-M25 and Chapter 13. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block M00-M25 applies to 2,249 codes
  • Disorders affecting predominantly peripheral (limb) joints

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

On M04 itself
From Chapter 13 (M00-M99) Diseases of the musculoskeletal system and connective tissue applies to 6,687 codes
  • arthropathic psoriasis (L40.5-)
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • compartment syndrome (traumatic) (T79.A-)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Notes

General instructions on how these codes are used.

From Chapter 13 (M00-M99) Diseases of the musculoskeletal system and connective tissue applies to 6,687 codes
  • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name M04, its category, or a range that includes it.

Code Also 1

These codes say M04 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • E85.0 Non-neuropathic heredofamilial amyloidosis
    autoinflammatory syndromes (M04.-)

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Code HistoryHistory

FY 2019AddedAdded to the ICD-10-CM code setEffective October 1, 2018.
FY 2020–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About M04Overview

What is the ICD-10 code for autoinflammatory syndromes?

M04 is the ICD-10-CM category for autoinflammatory syndromes, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is M04 (Autoinflammatory syndromes) a billable code?

No. This is a category header that groups the codes for autoinflammatory syndromes, and headers cannot be submitted on claims. Claims for autoinflammatory syndromes need a more specific code from this category, such as M04.1, M04.2, and M04.3.