2026 ICD-10-CM Diagnosis Code F89Unspecified disorder of psychological development

AHRQ’s CCSR groups this code into broader clinical categories.

• Acanthosis Nigricans

  a circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. it occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.

• Insulin Resistance

  diminished effectiveness of insulin in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

• Metabolic Syndrome

  a cluster of symptoms that are risk factors for cardiovascular diseases and type 2 diabetes mellitus. the major components of metabolic syndrome include abdominal obesity; atherogenic dyslipidemia; hypertension; hyperglycemia; insulin resistance; a proinflammatory state; and a prothrombotic (thrombosis) state.

• Achondroplasia

  an autosomal dominant disorder that is the most frequent form of short-limb dwarfism. affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand. (online mendelian inheritance in man, http://www.ncbi.nlm.nih.gov/omim, mim#100800, april 20, 2001)

• Intellectual Developmental Disorder with Hypotonia, Impaired Speech, and Dysmorphic Facies|IDDHISD

  an autosomal dominant condition caused by mutation(s) in the tnpo2 gene, encoding transportin-2. it is characterized by intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (iddhisd).

• Intellectual Developmental Disorder, Autosomal Dominant 42|MRD42

  an autosomal dominant subtype of intellectual developmental disorder caused by mutation(s) in the gnb1 gene, encoding guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

• Neurodevelopmental Disorder with Cardiomyopathy, Spasticity, and Brain Abnormalities|NEDCASB

  an autosomal recessive condition caused by mutation(s) in the shmt2 gene, encoding serine hydroxymethyltransferase, mitochondrial. it is characterized by global neurodevelopmental delay, severely impaired intellectual development, poor overall growth, and spasticity of the lower limbs. most affected individuals also have progressive hypertrophic cardiomyopathy in childhood or cardiac developmental anomalies.

• Neurodevelopmental Disorder with Epilepsy, Spasticity, and Brain Atrophy|NEDESBA

  an autosomal recessive condition caused by mutation(s) in the trappc4 gene, encoding trafficking protein particle complex subunit 4. it is characterized by severely impaired global development, seizures during infancy, lack of psychomotor progress, hypotonia, peripheral spasticity with contractures, cortical visual impairment, and dysmorphia, including microcephaly.

• Neurodevelopmental Disorder with Language Impairment, Autism, and Attention Deficit-Hyperactivity Disorder|NEDLAAD

  an autosomal dominant condition caused by mutation(s) in the caprin1 gene, encoding caprin-1. it is characterized by speech and motor delays, language difficulties, behavioral abnormalities, variably impaired intellectual development, mild ocular and distal skeletal anomalies, and nonspecific dysmorphic features.

• Achondrogenesis

  a rare group of disorders characterized by defective development of bones and cartilage.

• Type II Achondrogenesis|Achondrogenesis, Type II|Hypochondrogenesis|Langer-Saldino Achondrogenesis

  an autosomal dominant condition caused by mutation(s) in the col2a1 gene, encoding collagen alpha-1(ii) chain. it is the most severe of a spectrum of disorders caused by mutations in the col2a1 gene, characterized by short limbs, small chest and lungs, and abnormal ossification of the spine and pelvis. often, infants die at birth or shortly thereafter.

• Acanthosis Nigricans

  a melanotic cutaneous lesion that develops in the axilla and other body folds. it may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy.

• Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome|HAIR-AN Syndrome

  a condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. it is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor.

• Insulin Resistant Diabetes Mellitus with Acanthosis Nigricans and Hyperandrogenism|Type A Insulin Resistance Syndrome

  a syndrome of insulin resistance caused by mutation(s) in the insr gene, encoding the insulin receptor. this condition is characterized by a clinical triad of hyperinsulinemia, acanthosis nigricans, and hyperandrogenism without lipodystrophy. this is the least severe of a spectrum of disorders; the other two conditions are rabson-mendenhall syndrome and donohoe syndrome.

• Alcohol Related Neurodevelopmental Disorder|ARND

  a cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. typically, this presents without facies or other growth abnormalities.

• Autism Spectrum Disorder|Pervasive Developmental Disorders

  a spectrum of developmental disorders that includes autism, asperger syndrome, and rett syndrome. signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.

• Dental Developmental Disorder|Tooth Development Disorder|Tooth development disorder

  a disorder of the teeth arising during odontogenesis.

• Developmental Disorder

  a disorder diagnosed in childhood that is marked by either physical or mental impairment or both, which in turn affects the child from achieving age related developmental milestones.

• Fetal Neurodevelopmental Disorder

  a fetal affliction that has a neurological basis and manifests as a developmental disability.

• Intellectual Developmental Disorder with Cardiac Arrhythmia|IDDCA

  an autosomal recessive condition caused by mutation(s) in the gnb5 gene, encoding guanine nucleotide-binding protein subunit beta-5. it is characterized by severe intellectual disability, poor speech acquisition, and cardiac arrhythmia. biallelic missense mutation in the gnb5 gene can cause language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia, which is a less-severe disorder with overlapping features.

• Intellectual Developmental Disorder, X-linked, Syndromic, Bain Type|Bain Type of X-linked Syndromic Intellectual Disability|MRXSB

  an x-linked dominant condition caused by mutation(s) in the hnrnph2 gene, encoding heterogeneous nuclear ribonucleoprotein h2. it is characterized by delayed psychomotor development, intellectual disability with behavioral abnormalities, and dysmorphic facial features in females.

• Neurodevelopmental Disorder

  a childhood disorder that has a neurological basis and manifests as a developmental disability.

• Neurodevelopmental Disorder with Brain Abnormalities, Poor Growth, and Dysmorphic Facies|Intellectual Disability-Strabismus Syndrome|NEDBGF

  an autosomal recessive disorder caused by mutation(s) in the adat3 gene, encoding probable inactive trna-specific adenosine deaminase-like protein 3. it is characterized by a neurodevelopmental disorder with brain abnormalities, poor growth, and abnormal facies.

• Neurodevelopmental Disorder with Severe Motor Impairment, Absent Language, Cerebral Hypomyelination, and Brain Atrophy|NEDMLHB

  an autosomal recessive condition caused by mutations(s) in the taf8 gene, encoding transcription initiation factor tfiid subunit 8. it is characterized by severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy.

• Neurodevelopmental Disorder with Spastic Diplegia and Visual Defects|MRD19|Mental Retardation, Autosomal Dominant 19|NEDSDV

  an autosomal dominant condition caused by mutation(s) in the ctnnb1 gene, encoding catenin beta-1. it is characterized by severe intellectual disability, progressive spastic diplegia, visual impairment, and dysmorphic craniofacial features.

• Pervasive Developmental Disorder

  a category of developmental disorders characterized by impaired communication and socialization skills. the impairments are incongruent with the individual's developmental level or mental age. these disorders can be associated with general medical or genetic conditions.

• Acute Motor and Sensory Axonal Neuropathy|Acute Motor And Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy

  a subtype of guillain-barre syndrome that targets sensory motor axons, and is characterized by acute onset of quadriparesis, distal sensory loss, areflexia, and respiratory insufficiency.

• Acute Motor Axonal Neuropathy|AMAN

  a subtype of guillain-barre syndrome that targets motor axons, and is characterized by symmetric limb weakness, diffuse areflexia, facial and oropharyngeal muscle weakness, and respiratory insufficiency.

• Axonal Neuropathy

  any nerve disorder affecting the axon of a nerve.

• GAN wt Allele|GAN1|Giant Axonal Neuropathy (Gigaxonin) Gene|Gigaxonin wt Allele|KLHL16

  human gan wild-type allele is located in the vicinity of 16q24.1 and is approximately 65 kb in length. this allele, which encodes gigaxonin protein, is involved in both ubiquitination and neurofilament structure. mutation of the gene is associated with giant axonal neuropathy.

• Giant Axonal Neuropathy

  a rare inherited disorder affecting the neurofilaments. it is caused by mutations in the gan gene. it is characterized by the presence of abnormally large nerve cell axons. signs and symptoms include difficulty walking, sensory disturbances, lack of motor coordination and abnormal reflexes in the limbs.

• Spinocerebellar Ataxia, Autosomal Recessive, with Axonal Neuropathy 2|AOA2|Ataxia with Oculomotor Apraxia Type 2|SCAN2

  an autosomal recessive condition caused by mutation(s) in the setx gene, encoding probable helicase senataxin. it is characterized by juvenile onset progressive cerebellar ataxia, axonal sensorimotor peripheral neuropathy, and increased concentrations of serum alpha-fetoprotein. oculomotor apraxia is common, but is not always present.

• Cortical Blindness

  visual impairment due to visual cortex dysfunction.

• Homeostatic Model Assessment of Insulin Resistance

  an assessment of beta-cell function and insulin resistance based on fasting blood glucose and insulin concentrations.

• Insulin Receptor Mutation - Associated Insulin Resistance Syndromes

  insulin resistance caused by inactivating mutation(s) in the insr gene encoding the insulin receptor.

• Insulin Resistance

  decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia.

• Insulin Resistance Measurement|INSULINR|Insulin Resistance|Insulin Resistance

  the determination of the insulin resistance (cells inability to respond to insulin) in a biological specimen.

• Insulin Resistance Syndrome

  a cluster of closely related metabolic abnormalities associated with insulin resistance that confer an increased risk of the development of type 2 diabetes and cardiovascular disease. these abnormalities may include obesity, high blood pressure, abnormal cholesterol levels, proteinuria, and/or polycystic ovary syndrome.

• Obesity-Associated Insulin Resistance

  insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.

• Achondroplasia

  an autosomal dominant disorder caused by mutation(s) in the fgfr3 gene, encoding fibroblast growth factor receptor 3. the condition is characterized by inappropriate cartilage growth plate differentiation and deficient endochondral growth, manifest clinically with severe rhizomelic short stature, short limbs, characteristic facies with frontal bossing and midface hypoplasia.

• COMP wt Allele|Cartilage Oligomeric Matrix Protein (Pseudoachondroplasia, Epiphyseal Dysplasia 1, Multiple) Gene|Cartilage Oligomeric Matrix Protein wt Allele|Cartilage Oligomeric Matrix Protein(Pseudoachondroplasia, Epiphyseal Dysplasia 1, Multiple) Gene|EDM1|EPD1|MED|PSACH|Pseudoachondroplasia (Epiphyseal Dysplasia 1, Multiple) Gene|THBS5

  human comp wild-type allele is located in the vicinity of 19p13.1 and is approximately 9 kb in length. this allele, which encodes cartilage oligomeric matrix protein, is involved in cartilage structural integrity. mutation of the gene is associated with pseudoachondroplasia and multiple epiphyseal dysplasia 1.

• FGFR3 wt Allele|ACH|Achondroplasia, Thanatophoric Dwarfism Gene|CD333|CEK2|FGFR3|Fibroblast Growth Factor Receptor 3 (Achondroplasia, Thanatophoric Dwarfism) Gene|Fibroblast Growth Factor Receptor 3 wt Allele|HSFGFR3EX|JTK4

  human fgfr3 wild-type allele is located in the vicinity of 4p16.3 and is approximately 15 kb in length. this allele, which encodes fibroblast growth factor receptor 3 protein, is involved in mitogenesis, differentiation, and bone development and maintenance. alterations in the gene resulting in defects cause, achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers.

• Pseudoachondroplasia

  a rare, autosomal dominant inherited disorder caused by mutations in the comp gene. it is characterized by short stature, short arms and legs, waddling walk, osteoarthritis, and limited range of motion at the elbows and hips.

• Intellectual Developmental Disorder, Autosomal Dominant 52|MRD52|Mental Retardation, Autosomal Dominant 52

  an autosomal dominant subtype of intellectual developmental disorder caused by mutation(s) in the ash1l gene, encoding histone-lysine n-methyltransferase ash1l.

• Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type|MRXSN

  an x-linked recessive condition caused by mutation(s) in the ube2a gene, encoding ubiquitin-conjugating enzyme e2 a. it is characterized by facial dysmorphisms and intellectual impairment.

• Neurodevelopmental Disorder with or without Autistic Features and/or Structural Brain Abnormalities|NEDASB

  an autosomal dominant condition caused by mutation(s) in the nova2 gene, encoding rna-binding protein nova-2. it is characterized by global developmental delay, impaired speech development, and behavioral characteristics of autism.

• Neurodevelopmental Disorder with or without Hyperkinetic Movements and Seizures, Autosomal Dominant|NDHMSD

  an autosomal dominant condition caused by mutation(s) in the grin1 gene, encoding glutamate receptor ionotropic, nmda 1. it is characterized by developmental delay, intellectual disability and may include epilepsy and associated muscular disorders.

• Neurodevelopmental Disorder with or without Variable Brain Abnormalities|NEDBA

  an autosomal dominant condition caused by mutation(s) in the mapk8ip3 gene, encoding c-jun-amino-terminal kinase-interacting protein 3. it is commonly characterized by global developmental delay, intellectual disability, and spastic diplegia. there may be associated brain abnormalities include cerebellar and/or cerebral atrophy, and hypoplasia of the corpus callosum.

• X-Linked Syndromic Intellectual Developmental Disorder with Pigmentary Mosaicism and Coarse Facies|MRXSPF

  an x-linked condition caused by mutation(s) in the tfe3 gene, encoding transcription factor e3. it is characterized by a triad of developmental delay, blaschkoid pigmentary mosaicism, and characteristic coarse facial features.

Developmental Disabilities

Developmental disabilities are conditions that are usually present at birth. They can affect a child's growth and development. These conditions can cause physical, learning, language, or behavior issues. They can include:

The full article covers:

• What are developmental disabilities?
• What causes developmental disabilities?
• How are developmental disabilities diagnosed?
• What are the treatments for developmental disabilities?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.