3E04305Introduction of Other Antineoplastic into Central Vein, Percutaneous Approach

Administration›Physiological Systems and Anatomical Regions›Introduction

Billable / Specific Code

ICD-10-PCS 3E04305

CMS Source: FY 2026 ICD-10-PCS dataset. Effective Oct 1, 2025 – Sep 30, 2026.

3E04305 is a billable ICD-10-PCS procedure code for Introduction of Other Antineoplastic into Central Vein, Percutaneous Approach. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The root operation Introduction involves putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

Code Identity

ICD-10-PCS Code

3E04305

Billable Status

Yes — Valid for Submission

Code Describes

Introduction of Other Antineoplastic into Central Vein, Percutaneous Approach

Parent Code

3E0

Short Description

Introduce Oth Antineoplastic in Central Vein, Perc

PCS Table Breakdown

Each ICD-10-PCS code is built from seven characters, each an axis of the procedure. Hover or tap the icons for the official CMS definitions.

Position	Designation	Value	Meaning
1	Section	3	Administration
2	Body System	E	Physiological Systems and Anatomical Regions
3	Operation	0	Introduction
4	BodySystem/Region	4	Central Vein
5	Approach	3	Percutaneous
6	Substance	0	Antineoplastic
7	Qualifier	5	Other Antineoplastic

Convert to ICD-9-PCS

Closest ICD-9-PCS equivalents for 3E04305 under the General Equivalence Mappings.

39.96

Approximate match.

99.25

Approximate match.

Code History

Replaced in the FY 2026 code set by:

XW04358 — Introduce Mosunetuzumab in Central Vein, Perc, New Tech 8
XW04368 — Introduce Afamitresgene in Central Vein, Perc, New Tech 8
XW04378 — Introduce Tabelecleucel in Central Vein, Perc, New Tech 8
XW04387 — Introduce Lurbinectedin in Central Vein, Perc, New Tech 7
XW0439A — Introduce Odronextamab in Central Vein, Perc, New Tech 10
XW043B3 — Introduce cytarab/daunorub in Central Vein, Perc, New Tech 3
XW043C3 — Introduce Auto CAR T cell in Central Vein, Perc, New Tech 3
XW043CA — Introduce Zanidatamab in Central Vein, Perc, New Tech 10
XW043D6 — Introduce Atezolizumab in Central Vein, Perc, New Tech 6
XW043NA — Introduce Tarlatamab-dlle in Central Vein, Perc, New Tech 1
XW043P9 — Introduce Glofitamab in Central Vein, Perc, New Tech 9
XW043Q5 — Introduce Tagraxofusp-erzs in Central Vein, Perc, New Tech 5
XW043S5 — Introduce Iobenguane I-131 in Central Vein, Perc, New Tech 5
XW24346 — Transfuse Brexcab Autoleuc in Central Vein, Perc, New Tech 6
XW24376 — Transfuse Lisocab Maraleuc in Central Vein, Perc, New Tech 6

Similar Procedure Codes

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Questions About 3E04305

Is 3E04305 a billable code?

Yes. 3E04305 is a complete seven-character ICD-10-PCS code, specific enough to report Introduction of Other Antineoplastic into Central Vein, Percutaneous Approach on inpatient claims from October 1, 2025 through September 30, 2026.

What do the characters in 3E04305 mean?

3E04305 breaks down character by character: the 1st character 3 is the Section (Administration); the 2nd character E is the Body System (Physiological Systems and Anatomical Regions); the 3rd character 0 is the Operation (Introduction); the 4th character 4 is the BodySystem/Region (Central Vein); the 5th character 3 is the Approach (Percutaneous); the 6th character 0 is the Substance (Antineoplastic); the 7th character 5 is the Qualifier (Other Antineoplastic).

What is the ICD-9-PCS equivalent of 3E04305?

Under the General Equivalence Mappings, Introduction of Other Antineoplastic into Central Vein, Percutaneous Approach crosswalks to ICD-9-PCS 39.96 and 99.25. The mapping is approximate, so confirm it fits the documentation.