Adverse effects, not elsewhere classified (T78)
Clinical Information
Anaphylaxis - An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Angioedema - Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
Angioedemas, Hereditary - Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.
Exercise-Induced Allergies - Allergic reactions following a period of exercise. Elevated serum HISTAMINE and TRYPTASE levels and cutaneous MAST CELL degranulation are often associated with post-exertional allergic reactions which sometimes are triggered only in combination with prior consumption of a specific food such as wheat. Allergic symptoms produced post-exercise range from skin eruption, asthma, bronchospasm, and anaphylaxis.
Hereditary Angioedema Type III - A form of hereditary angioedema that occurs in women and is precipitated or worsened by high ESTROGEN levels. It is associated with mutations in the gene for FACTOR XII that result in its increased activity.
Hereditary Angioedema Types I and II - Forms of hereditary angioedema that occur due to mutations in the gene for COMPLEMENT C1 INHIBITOR PROTEIN. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein.
Histamine Release - The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.
Passive Cutaneous Anaphylaxis - An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Venom Hypersensitivity - Allergic reaction to venoms in insect bites and stings that is triggered by the immune system (i.e., HISTAMINE RELEASE).
Instructional Notations
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
7th Character Note
Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
- The appropriate 7th character is to be added to each code from category T78
7th Character
Indicates that a seventh character is to be assigned to codes in a subcategory.
- A - initial encounter
- D - subsequent encounter
- S - sequela
Injury, poisoning and certain other consequences of external causes (S00–T88)
Other and unspecified effects of external causes (T66-T78)
T78 Adverse effects, not elsewhere classified
T78.0 Anaphylactic reaction due to food
T78.00 Anaphylactic reaction due to unspecified food
- T78.00XA Anaphylactic reaction due to unspecified food, initial encounter
- T78.00XD Anaphylactic reaction due to unspecified food, subsequent encounter
- T78.00XS Anaphylactic reaction due to unspecified food, sequela
T78.01 Anaphylactic reaction due to peanuts
- T78.01XA Anaphylactic reaction due to peanuts, initial encounter
- T78.01XD Anaphylactic reaction due to peanuts, subsequent encounter
- T78.01XS Anaphylactic reaction due to peanuts, sequela
T78.02 Anaphylactic reaction due to shellfish (crustaceans)
- T78.02XA Anaphylactic reaction due to shellfish (crustaceans), initial encounter
- T78.02XD Anaphylactic reaction due to shellfish (crustaceans), subsequent encounter
- T78.02XS Anaphylactic reaction due to shellfish (crustaceans), sequela
T78.03 Anaphylactic reaction due to other fish
- T78.03XA Anaphylactic reaction due to other fish, initial encounter
- T78.03XD Anaphylactic reaction due to other fish, subsequent encounter
- T78.03XS Anaphylactic reaction due to other fish, sequela
T78.04 Anaphylactic reaction due to fruits and vegetables
- T78.04XA Anaphylactic reaction due to fruits and vegetables, initial encounter
- T78.04XD Anaphylactic reaction due to fruits and vegetables, subsequent encounter
- T78.04XS Anaphylactic reaction due to fruits and vegetables, sequela
T78.05 Anaphylactic reaction due to tree nuts and seeds
- T78.05XA Anaphylactic reaction due to tree nuts and seeds, initial encounter
- T78.05XD Anaphylactic reaction due to tree nuts and seeds, subsequent encounter
- T78.05XS Anaphylactic reaction due to tree nuts and seeds, sequela
T78.06 Anaphylactic reaction due to food additives
- T78.06XA Anaphylactic reaction due to food additives, initial encounter
- T78.06XD Anaphylactic reaction due to food additives, subsequent encounter
- T78.06XS Anaphylactic reaction due to food additives, sequela
T78.07 Anaphylactic reaction due to milk and dairy products
- T78.07XA Anaphylactic reaction due to milk and dairy products, initial encounter
- T78.07XD Anaphylactic reaction due to milk and dairy products, subsequent encounter
- T78.07XS Anaphylactic reaction due to milk and dairy products, sequela
T78.08 Anaphylactic reaction due to eggs
- T78.08XA Anaphylactic reaction due to eggs, initial encounter
- T78.08XD Anaphylactic reaction due to eggs, subsequent encounter
- T78.08XS Anaphylactic reaction due to eggs, sequela
T78.09 Anaphylactic reaction due to other food products
- T78.09XA Anaphylactic reaction due to other food products, initial encounter
- T78.09XD Anaphylactic reaction due to other food products, subsequent encounter
- T78.09XS Anaphylactic reaction due to other food products, sequela
T78.1 Other adverse food reactions, not elsewhere classified
- T78.1XXA Other adverse food reactions, not elsewhere classified, initial encounter
- T78.1XXD Other adverse food reactions, not elsewhere classified, subsequent encounter
- T78.1XXS Other adverse food reactions, not elsewhere classified, sequela
T78.2 Anaphylactic shock, unspecified
- T78.2XXA Anaphylactic shock, unspecified, initial encounter
- T78.2XXD Anaphylactic shock, unspecified, subsequent encounter
- T78.2XXS Anaphylactic shock, unspecified, sequela
T78.3 Angioneurotic edema
- T78.3XXA Angioneurotic edema, initial encounter
- T78.3XXD Angioneurotic edema, subsequent encounter
- T78.3XXS Angioneurotic edema, sequela
T78.4 Other and unspecified allergy
T78.40 Allergy, unspecified
- T78.40XA Allergy, unspecified, initial encounter
- T78.40XD Allergy, unspecified, subsequent encounter
- T78.40XS Allergy, unspecified, sequela
T78.41 Arthus phenomenon
- T78.41XA Arthus phenomenon, initial encounter
- T78.41XD Arthus phenomenon, subsequent encounter
- T78.41XS Arthus phenomenon, sequela
T78.49 Other allergy
- T78.49XA Other allergy, initial encounter
- T78.49XD Other allergy, subsequent encounter
- T78.49XS Other allergy, sequela
T78.8 Other adverse effects, not elsewhere classified
- T78.8XXA Other adverse effects, not elsewhere classified, initial encounter
- T78.8XXD Other adverse effects, not elsewhere classified, subsequent encounter
- T78.8XXS Other adverse effects, not elsewhere classified, sequela
Adverse effects, not elsewhere classified (T78)