3E00XGFIntroduction of Other Enzymatic/Chemical Agent into Skin and Mucous Membranes, External Approach

Administration›Physiological Systems and Anatomical Regions›Introduction
ICD-10-PCS 3E00XGF
CMS Source: FY 2027 ICD-10-PCS dataset. Effective Oct 1, 2026 – Sep 30, 2027.FacebookXLinkedInPrint

3E00XGF is a billable ICD-10-PCS procedure code for Introduction of Other Enzymatic/Chemical Agent into Skin and Mucous Membranes, External Approach. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027). The root operation Introduction involves putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

Code Identity

ICD-10-PCS Code
3E00XGF
Billable Status
Yes — Valid for Submission
Code Describes
Introduction of Other Enzymatic/Chemical Agent into Skin and Mucous Membranes, External Approach
Short Description
Introduce Oth Enzym/Chem Agt in Skin/Mucous Mem, Extern
Parent Code
3E0

PCS Table Breakdown

Each ICD-10-PCS code is built from seven characters, each an axis of the procedure. Hover or tap the icons for the official CMS definitions.

PositionDesignationValueMeaning
1Section3Administration
2Body SystemEPhysiological Systems and Anatomical Regions
3Operation0Introduction
4BodySystem/Region0Skin and Mucous Membranes
5ApproachXExternal
6SubstanceGOther Therapeutic Substance
7QualifierFOther Enzymatic/Chemical Agent

In the ICD-10-PCS Alphabetic Index

These FY 2027 ICD-10-PCS Alphabetic Index entries lead to this code:

NexoBrid(tm)
Anatomy or device term that leads here
TAVALISSE(R)
Anatomy or device term that leads here
Trilaciclib
Anatomy or device term that leads here
Fostamatinib
Anatomy or device term that leads here
Tattooing, Skin
Leads to this code's table
Anacaulase-bcdb
Anatomy or device term that leads here
SANTYL Ointment
Anatomy or device term that leads here
Satralizumab-mwge
Anatomy or device term that leads here
COSELA(tm) (Trilaciclib)
Anatomy or device term that leads here
NexoBrid(tm) application
Anatomy or device term that leads here
Anacaulase-bcdb application
Anatomy or device term that leads here
Collagenase SANTYL Ointment
Anatomy or device term that leads here
SANTYL Ointment application
Anatomy or device term that leads here
ENSPRYNG(tm) (Satralizumab-mwge)
Anatomy or device term that leads here
Bromelain-enriched Proteolytic Enzyme
Anatomy or device term that leads here

To code tattooing of the skin, open the FY 2027 ICD-10-PCS Alphabetic Index at Tattooing, then the subterm Skin. The index leads to table 3E0, where the approach, substance and qualifier values shown in the breakdown above complete the seven-character code 3E00XGF.

Browse the full ICD-10-PCS Alphabetic Index →

Code History

FY 2027New code, effective October 1, 2026.
Replaces previously assigned code(s):
  • XW00X27 — Introduce Anacaulase-bcdb in Skin, Extern, New Tech 7

Similar Procedure Codes

Questions About 3E00XGF

Is 3E00XGF a billable code?

Yes. This is a complete seven-character ICD-10-PCS code, specific enough to report Introduction of Other Enzymatic/Chemical Agent into Skin and Mucous Membranes, External Approach on inpatient claims from October 1, 2026 through September 30, 2027.

What do the characters in 3E00XGF mean?

The code breaks down character by character: the 1st character 3 is the Section (Administration); the 2nd character E is the Body System (Physiological Systems and Anatomical Regions); the 3rd character 0 is the Operation (Introduction); the 4th character 0 is the BodySystem/Region (Skin and Mucous Membranes); the 5th character X is the Approach (External); the 6th character G is the Substance (Other Therapeutic Substance); the 7th character F is the Qualifier (Other Enzymatic/Chemical Agent).