3E00X29Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach

  • Billable / Specific Code
ICD-10-PCS 3E00X29
CMS Source: FY 2026 ICD-10-PCS dataset. Effective Oct 1, 2025 – Sep 30, 2026.FacebookXLinkedInPrint

3E00X29 is a billable ICD-10-PCS procedure code for Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The root operation Introduction involves putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products. In AHRQ's Clinical Classifications Software (CCSR), this procedure falls under Administration of antibiotics.

Code Identity

ICD-10-PCS Code
3E00X29
Billable Status
Yes — Valid for Submission
Code Describes
Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach
Short Description
Introduce Oth Anti-infect in Skin/Mucous Mem, Extern
Parent Code

PCS Table Breakdown

Each ICD-10-PCS code is built from seven characters, each an axis of the procedure. Hover or tap the icons for the official CMS definitions.

PositionDesignationValueMeaning
1Section3Administration
2Body SystemEPhysiological Systems and Anatomical Regions
3Operation0Introduction
4BodySystem/Region0Skin and Mucous Membranes
5ApproachXExternal
6Substance2Anti-infective
7Qualifier9Other Anti-infective

In the ICD-10-PCS Alphabetic Index

These FY 2026 ICD-10-PCS Alphabetic Index entries lead to this code:

Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Tattooing, Skin
Leads to this code's table
Anatomy or device term that leads here
Anatomy or device term that leads here
Insertion, Antimicrobial envelope
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here

To code tattooing of the skin, open the FY 2026 ICD-10-PCS Alphabetic Index at Tattooing, then the subterm Skin. The index leads to table 3E0, where the approach, substance and qualifier values shown in the breakdown above complete the seven-character code 3E00X29.

Browse the full ICD-10-PCS Alphabetic Index →

Clinical Classification (CCSR)

AHRQ groups this procedure code into these clinical categories.

ADM015
Administration of antibiotics
Clinical domain: Administration of Therapeutic Substances

Convert to ICD-9-PCS

Closest ICD-9-PCS equivalents for this code under the General Equivalence Mappings.

99.21
Injection of antibiotic
Approximate match.

Similar Procedure Codes

Questions About 3E00X29

Is 3E00X29 a billable code?

Yes. This is a complete seven-character ICD-10-PCS code, specific enough to report Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach on inpatient claims from October 1, 2025 through September 30, 2026.

What do the characters in 3E00X29 mean?

The code breaks down character by character: the 1st character 3 is the Section (Administration); the 2nd character E is the Body System (Physiological Systems and Anatomical Regions); the 3rd character 0 is the Operation (Introduction); the 4th character 0 is the BodySystem/Region (Skin and Mucous Membranes); the 5th character X is the Approach (External); the 6th character 2 is the Substance (Anti-infective); the 7th character 9 is the Qualifier (Other Anti-infective).

What is the ICD-9-PCS equivalent of 3E00X29?

Under the General Equivalence Mappings, Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach crosswalks to ICD-9-PCS 99.21 (Injection of antibiotic). The mapping is approximate, so confirm it fits the documentation.