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Version 2025
Billable Code

2025 ICD-10-CM Procedure Code 3E00XGC

Introduction of Other Therapeutic Substance into Skin and Mucous Membranes, External Approach

ICD-10-PCS Code:
3E00XGC
ICD-10-PCS Code for:
Introduce Oth Therap Subst in Skin/Mucous Mem, Extern
Is Billable?
Yes - Valid for Submission
Code Navigator:

3E00XGC is a billable procedure code used to specify the performance of introduction of other therapeutic substance into skin and mucous membranes, external approach. The code is valid for the year 2025 for the submission of HIPAA-covered transactions. The procedure code involves putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

3E00XGC PCS Table

In an PCS table each code is represented by up seven alphanumeric characters, with each character in the table respresenting different aspects of the procedure. In the table provided below, each row represents an individual character and includes information about the character's position, designation, label, and procedure notes. For this PCS table the procedure code is in the administration section and is part of the physiological systems and anatomical regions body system, classified under introduction operation. The applicable bodysystem/region for this procedure code is skin and mucous membranes.

Position Designation Character Label Procedures Notes
1 Section 3 Administration
2 Body System E Physiological Systems and Anatomical Regions
3 Operation 0 Introduction

Involves:
Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products
4 BodySystem/Region 0 Skin and Mucous Membranes  
5 Approach X External

Involves:
Procedures performed directly on the skin or mucous membrane and procedures performed indirectly by the application of external force through the skin or mucous membrane
6 Substance G Other Therapeutic Substance Includes:
  • Idarucizumab, Pradaxa(R)(dabigatran) reversal agent
  • Praxbind(R) (idarucizumab), Pradaxa(R)(dabigatran) reversal agent
7 Qualifier C Other Substance

Replaced Code

3E00XGC was replaced in the 2025 ICD-10-PCS code set with the code(s):

  • XW00X27 - Introduce Bromln Proteolyt Enzy in Skin, Extern, New Tech 7
  • XW00X27 - Introduce Bromln Proteolyt Enzy in Skin, Extern, New Tech 7
  • XW00X27 - Introduce Anacaulase-bcdb in Skin, Extern, New Tech 7
  • XW00X27 - Introduce Anacaulase-bcdb in Skin, Extern, New Tech 7

Clinical Classification

  • Clinical Category is Administration of therapeutic substances, NEC

  • CCSR Category Code: ADM021
  • Clinical Domain is Administration of Therapeutic Substances - ADM contains 22 categories that include procedures associated with the administration of therapeutic substances, such as the transfusion of blood and blood products, vaccinations, and chemotherapy.

Convert to ICD-9-PCS

The following crosswalk between ICD-10-PCS to ICD-9-PCS is based based on the General Equivalence Mappings (GEMS) information:

Other ICD-10-PCS Codes Used for Introduction Skin and Mucous Membranes


  • 3E00X05 Introduction of Other Antineoplastic into Skin and Mucous Membranes, External Approach
  • 3E00X0M Introduction of Antineoplastic, Monoclonal Antibody, into Skin and Mucous Membranes, External Approach
  • 3E00X28 Introduction of Oxazolidinones into Skin and Mucous Membranes, External Approach
  • 3E00X29 Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach
  • 3E00X3Z Introduction of Anti-inflammatory into Skin and Mucous Membranes, External Approach
  • 3E00X4Z Introduction of Serum, Toxoid and Vaccine into Skin and Mucous Membranes, External Approach
  • 3E00XBZ Introduction of Anesthetic Agent into Skin and Mucous Membranes, External Approach
  • 3E00XKZ Introduction of Other Diagnostic Substance into Skin and Mucous Membranes, External Approach
  • 3E00XMZ Introduction of Pigment into Skin and Mucous Membranes, External Approach
  • 3E00XNZ Introduction of Analgesics, Hypnotics, Sedatives into Skin and Mucous Membranes, External Approach
  • 3E00XTZ Introduction of Destructive Agent into Skin and Mucous Membranes, External Approach

What is ICD-10-PCS?

The ICD-10 Procedure Coding System (ICD-10-PCS) is a catalog of procedural codes used by medical professionals for hospital inpatient healthcare settings. The Centers for Medicare and Medicaid Services (CMS) maintain the catalog in the U.S. releasing yearly updates. The 2025 ICD-10-PCS codes are to be used for discharges occurring from October 1, 2024 through September 30, 2025.

Each ICD-10-PCS code has a structure of seven alphanumeric characters and contains no decimals. The first character defines the major "section". Depending on the "section" the second through seventh characters mean different things.