3E0S302Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach

  • Billable / Specific Code
ICD-10-PCS 3E0S302
CMS Source: FY 2027 ICD-10-PCS dataset. Effective Oct 1, 2026 – Sep 30, 2027.FacebookXLinkedInPrint

3E0S302 is a billable ICD-10-PCS procedure code for Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRGs 837, 838. The root operation Introduction involves putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products. In AHRQ's Clinical Classifications Software (CCSR), this procedure falls under Chemotherapy.

Code Identity

ICD-10-PCS Code
3E0S302
Billable Status
Yes — Valid for Submission
Code Describes
Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach
Short Description
Introduce High dose IL-2 in Epidural Space, Perc
Parent Code

PCS Table Breakdown

Each ICD-10-PCS code is built from seven characters, each an axis of the procedure. Hover or tap the icons for the official CMS definitions.

PositionDesignationValueMeaning
1Section3Administration
2Body SystemEPhysiological Systems and Anatomical Regions
3Operation0Introduction
4BodySystem/RegionSEpidural Space
5Approach3Percutaneous
6Substance0Antineoplastic
7Qualifier2High-dose Interleukin-2

In the ICD-10-PCS Alphabetic Index

These FY 2027 ICD-10-PCS Alphabetic Index entries lead to this code:

Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Anatomy or device term that leads here
Immunotherapy, antineoplastic, Proleukin, high-dose
Anatomy or device term that leads here
Immunotherapy, antineoplastic, Interleukin-2, high-dose
Anatomy or device term that leads here
Leads to this code's table
Introduction of substance in or on, Epidural Space, Antineoplastic
Leads to this code's table

Browse the full ICD-10-PCS Alphabetic Index →

Clinical Classification (CCSR)

AHRQ groups this procedure code into these clinical categories.

ADM012
Chemotherapy
Clinical domain: Administration of Therapeutic Substances

Convert to ICD-9-PCS

Closest ICD-9-PCS equivalents for this code under the General Equivalence Mappings.

00.15
High-dose infusion interleukin-2 [IL-2]
Approximate match.

Similar Procedure Codes

Questions About 3E0S302

Is 3E0S302 a billable code?

Yes. This is a complete seven-character ICD-10-PCS code, specific enough to report Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach on inpatient claims from October 1, 2026 through September 30, 2027.

What do the characters in 3E0S302 mean?

The code breaks down character by character: the 1st character 3 is the Section (Administration); the 2nd character E is the Body System (Physiological Systems and Anatomical Regions); the 3rd character 0 is the Operation (Introduction); the 4th character S is the BodySystem/Region (Epidural Space); the 5th character 3 is the Approach (Percutaneous); the 6th character 0 is the Substance (Antineoplastic); the 7th character 2 is the Qualifier (High-dose Interleukin-2).

What MS-DRG does 3E0S302 group to?

On an inpatient stay, Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach maps to MS-DRGs 837, 838, with relative weights from 2.1576 to 4.7104. The MS-DRG sets the fixed Medicare payment for the stay.

What is the ICD-9-PCS equivalent of 3E0S302?

Under the General Equivalence Mappings, Introduction of High-dose Interleukin-2 into Epidural Space, Percutaneous Approach crosswalks to ICD-9-PCS 00.15 (High-dose infusion interleukin-2 [IL-2]). The mapping is approximate, so confirm it fits the documentation.