XXE Measurement - Physiological Systems ICD-10-PCS
The XXE code range contains 22 ICD-10-PCS codes for Measurement procedures on the physiological systems. 21 of the codes are billable and valid for inpatient claim submission in fiscal year 2026.
Root Operation Definition
Measurement: Determining the level of a physiological or physical function at a point in time.
Codes in the XXE Range 22 codes · 21 billable
- XXE New Technology, Physiological Systems, MeasurementNon-billable header
- XXE0X07 Measurement of Intracranial Vascular Activity, Computer-aided Assessment, New Technology Group 7
- XXE0X1A Measurement of Intracranial Cerebrospinal Fluid Flow, Computer-aided Triage and Notification, New Technology Group 10 New
- XXE0X48 Measurement of Brain Electrical Activity, Computer-aided Semiologic Analysis, New Technology Group 8
- XXE2X19 Measurement of Cardiac Output, Computer-aided Assessment, New Technology Group 9
- XXE3X27 Measurement of Pulmonary Artery Flow, Computer-aided Triage and Notification, New Technology Group 7
- XXE3X58 Measurement of Coronary Artery Flow, Quantitative Flow Ratio Analysis, New Technology Group 8
- XXE3X68 Measurement of Coronary Artery Flow, Computer-aided Valve Modeling and Notification, New Technology Group 8
- XXE5X2A Measurement of Infection, Phenotypic Fully Automated Rapid Susceptibility Technology with Controlled Inoculum, New Technology Group 10 New
- XXE5X38 Measurement of Infection, Whole Blood Reverse Transcription and Quantitative Real-time Polymerase Chain Reaction, New Technology Group 8
- XXE5X4A Measurement of Infection, Positive Blood Culture Small Molecule Sensor Array Technology, New Technology Group 10 New
- XXE5XN6 Measurement of Infection, Positive Blood Culture Fluorescence Hybridization for Organism Identification, Concentration and Susceptibility, New Technology Group 6
- XXE5XR7 Measurement of Infection, Mechanical Initial Specimen Diversion Technique Using Active Negative Pressure, New Technology Group 7
- XXE5XT7 Measurement of Intracranial Arterial Flow, Whole Blood mRNA, New Technology Group 7
- XXE5XV7 Measurement of Infection, Serum/Plasma Nanoparticle Fluorescence SARS-CoV-2 Antibody Detection, New Technology Group 7
- XXE5XY9 Measurement of Infection, Other Positive Blood/Isolated Colonies Bimodal Phenotypic Susceptibility Technology, New Technology Group 9
- XXE97U7 Measurement of Infection, Nasopharyngeal Fluid SARS-CoV-2 Polymerase Chain Reaction, New Technology Group 7
- XXEBXQ6 Measurement of Infection, Lower Respiratory Fluid Nucleic Acid-base Microbial Detection, New Technology Group 6
- XXE5X5A Measurement of Immune Response, Whole Blood Cellular Assessment via Microfluidic Deformability, New Technology Group 10
- XXE5XBB Measurement of Infection and Immune Response, Gene Expression Testing System, New Technology Group 11 New
- XXEZXAB Measurement of Macronutrient Content, Computer-aided Assessment for Nutrition Management, New Technology Group 11 New
- XXEZXCB Measurement of Infection, Computer-aided Triage and Notification, New Technology Group 11 New
About the XXE Code Range
The ICD-10-PCS root operation Measurement (XXE) under the New Technology section involves quantifying a physiological function or infection using advanced methods. It focuses on obtaining precise data without altering an anatomical structure.
The provided codes highlight the application of New Technology Measurement across various physiological systems. For example, measurement of Intracranial Vascular Activity (XXE0X07), Brain Electrical Activity (XXE0X48), and Cardiac Output (XXE2X19) use computer-aided assessments for complex cardiovascular and neurological functions. Additionally, these codes include sophisticated infection measurements such as Whole Blood PCR for SARS-CoV-2 (XXE5X38) and Serum/Plasma Nanoparticle Fluorescence Antibody Detection (XXE5XV7). Each code designates a specific new technology group and method, reflecting advances in diagnostic accuracy and automated data interpretation. Proper use of these codes ensures detailed documentation of cutting-edge physiological and infectious disease measurements in modern healthcare.
Questions About This Page
How many billable codes are in the XXE range?
Of the 22 codes in this range, 21 are billable and valid for inpatient claim submission from October 1, 2025 through September 30, 2026. Table header codes group them but cannot be reported on claims.
What does the XXE range classify?
The range classifies Measurement procedures, determining the level of a physiological or physical function at a point in time, performed on the physiological systems. Each code adds the body part, approach, device, and qualifier in characters four through seven, and links to its own reference page.
Related References
Source: CMS FY 2026 ICD-10-PCS order file and code tables, effective October 1, 2025 through September 30, 2026.
