Deleted ICD-10-PCS Code XW0DX66 Introduction of Lefamulin Anti-infective into Mouth and Pharynx, External Approach, New Technology Group 6

New Technology›Anatomical Regions›Introduction
  • Deleted — Not Valid for Claims
  • Valid FY 2021–2025
  • Deleted in FY 2026
CMS Source: CMS ICD-10-PCS code files FY 2021–2025 and the ICD-10-PCS conversion table.
Do not report XW0DX66 for inpatient discharges on or after October 1, 2025. Claims with a deleted code are rejected. Use one of the replacement codes below.

XW0DX66 is a deleted ICD-10-PCS code, removed from the code set effective October 1, 2025. It was valid for introduction of Lefamulin Anti-infective into Mouth and Pharynx, External Approach, New Technology Group 6 on inpatient discharges from October 1, 2020 through September 30, 2025, and later discharges must use a current code. The CMS conversion table maps it to 3E0DX29.

Replacement Codes for XW0DX66

The CMS ICD-10-PCS conversion table maps XW0DX66 to this code. Confirm the choice against the procedure documentation and the code page's table.

  • 3E0DX29 Introduction of Other Anti-infective into Mouth and Pharynx, External Approach

Current Codes Starting With XW0D

Active FY 2027 codes that share the first 4 characters of XW0DX66 (same table and body part).

  • XW0DX38 Introduction of Maribavir Anti-infective into Mouth and Pharynx, External Approach, New Technology Group 8
  • XW0DX82 Introduction of Uridine Triacetate into Mouth and Pharynx, External Approach, New Technology Group 2
  • XW0DXF5 Introduction of Other New Technology Therapeutic Substance into Mouth and Pharynx, External Approach, New Technology Group 5
  • XW0DXJ9 Introduction of Quizartinib Antineoplastic into Mouth and Pharynx, External Approach, New Technology Group 9
  • XW0DXK8 Introduction of Sabizabulin into Mouth and Pharynx, External Approach, New Technology Group 8
  • XW0DXM6 Introduction of Baricitinib into Mouth and Pharynx, External Approach, New Technology Group 6
  • XW0DXN9 Introduction of SER-109 into Mouth and Pharynx, External Approach, New Technology Group 9
  • XW0DXVB Introduction of Xanomeline and Trospium Chloride into Mouth and Pharynx, External Approach, New Technology Group 11

Code History

FY 2021AddedAdded to the ICD-10-PCS code setEffective October 1, 2020.
FY 2025Last fiscal year the code was validValid for discharges through September 30, 2025.
FY 2026DeletedRemoved from the ICD-10-PCS code setEffective October 1, 2025.

Questions About XW0DX66

Is XW0DX66 still a valid ICD-10-PCS code?

No. XW0DX66 was deleted from ICD-10-PCS effective October 1, 2025, with the FY 2026 code set. It cannot be reported for inpatient discharges on or after that date.

What replaced XW0DX66?

The CMS ICD-10-PCS conversion table maps XW0DX66 to 3E0DX29. Confirm it matches the procedure documentation before you use it; a conversion is a starting point, not an automatic substitution.

Can I still use XW0DX66 for older discharges?

Yes, for inpatient discharges from October 1, 2020 through September 30, 2025. ICD-10-PCS codes are assigned by the code set in effect on the date of discharge, so a corrected or late claim for a discharge in that window still uses XW0DX66.