Skin changes due to chronic expsr to nonionizing radiation (L57)

• ICD-10 Index

  • Diseases of the skin and subcutaneous tissue (L00–L99)

    • Radiation-related disorders of the skin and subcutaneous tissue (L55-L59)

      • Skin changes due to chronic expsr to nonionizing radiation (L57)

        • L57 - Skin changes due to chronic expsr to nonionizing radiation NON-BILLABLE CODE
        • L57.0 - Actinic keratosis BILLABLE CODE
        • L57.1 - Actinic reticuloid BILLABLE CODE
        • L57.2 - Cutis rhomboidalis nuchae BILLABLE CODE
        • L57.3 - Poikiloderma of Civatte BILLABLE CODE
        • L57.4 - Cutis laxa senilis BILLABLE CODE
        • L57.5 - Actinic granuloma BILLABLE CODE
        • L57.8 - Oth skin changes due to chr expsr to nonionizing radiation BILLABLE CODE
        • L57.9 - Skin changes due to chr expsr to nonionizing radiation, unsp BILLABLE CODE

Clinical Information for Skin changes due to chronic expsr to nonionizing radiation (L57)

Darier Disease - An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.

Keratoderma, Palmoplantar - Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).

Keratoderma, Palmoplantar, Diffuse - An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.

Keratoderma, Palmoplantar, Epidermolytic - An autosomal dominant hereditary skin disease characterized by epidermolytic hyperkeratosis that is strictly confined to the palms and soles. It has been associated with mutations in the gene that codes for KERATIN-9.

Cutis Laxa - A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)

Keratosis - Any horny growth such as a wart or callus.

Keratosis, Seborrheic - Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.

Leukoplakia, Oral - A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).

Papillon-Lefevre Disease - Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth. Mutations in the gene for CATHEPSIN C have been associated with this disease.

Tyrosinemias - A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)

Keratin-9 - A type II keratin found predominantly expressed in the terminally differentiated EPIDERMIS of palms and soles. Mutations in the gene for keratin 9 are associated with KERATODERMA, PALMOPLANTAR, EPIDERMOLYTIC.

Instructional Notations

Use Additional Code Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.

• code to identify the source of the ultraviolet radiation W89 W90