ICD-9 Code 758.81

Other conditions due to sex chromosome anomalies

Not Valid for Submission

758.81 is a legacy non-billable code used to specify a medical diagnosis of other conditions due to sex chromosome anomalies. This code was replaced on September 30, 2015 by its ICD-10 equivalent.

ICD-9: 758.81
Short Description:Oth cond due to sex chrm
Long Description:Other conditions due to sex chromosome anomalies

Convert 758.81 to ICD-10

The following crosswalk between ICD-9 to ICD-10 is based based on the General Equivalence Mappings (GEMS) information:

  • Q97.0 - Karyotype 47, XXX
  • Q97.1 - Female with more than three X chromosomes
  • Q97.2 - Mosaicism, lines with various numbers of X chromosomes
  • Q97.8 - Oth sex chromosome abnormalities, female phenotype
  • Q98.5 - Karyotype 47, XYY
  • Q98.7 - Male with sex chromosome mosaicism
  • Q98.8 - Other specified sex chromosome abnormalities, male phenotype
  • Q99.8 - Other specified chromosome abnormalities

Code Classification

  • Congenital anomalies (740–759)
    • Congenital anomalies (740-759)
      • 758 Chromosomal anomalies

Information for Medical Professionals


  • 18p partial monosomy syndrome
  • 46, XX true hermaphrodite
  • Absence of sex chromosome
  • Additional sex chromosome
  • Anomaly of chromosome X
  • Anomaly of chromosome Y
  • Anomaly of sex chromosome
  • Barr body absent, nuclear sex male
  • Barr body, more than one present per cell
  • Chimera 46, XX; 46, XY
  • Double Y syndrome
  • Female with more than three X chromosomes
  • Four X syndrome
  • Fragile X chromosome
  • Karyotype 46, X iso
  • Karyotype 46, X with abnormal sex chromosome except iso
  • Male with structurally abnormal sex chromosome
  • Mosaic including XXXXY
  • Mosaic XO/XX
  • Mosaic XO/XY
  • Mosaic XY/XXY
  • Mosaicism - lines with various numbers of X chromosomes
  • Mosaicism 45, X / other cell line with abnormal sex chromosome
  • Penta X syndrome
  • Sex chromosome abnormality - female phenotype
  • Sex chromosome abnormality - male phenotype
  • Sex chromosome mosaicism
  • Sex phenotype-karyotype dissociation syndrome
  • Sex-linked hereditary disorder
  • Tetrasomy 12p
  • Triple X syndrome, epilepsy, and hypogammaglobulinemia
  • Trisomy X syndrome
  • Virilization of female due to SOX9 gene duplication
  • Virilization of female due to SRY gene translocation
  • X-linked creatine deficiency
  • X-linked intellectual deficit-dystonia-dysarthria syndrome
  • XX males
  • XXXXY syndrome
  • XXXY syndrome
  • XXYY syndrome
  • XY females
  • XY, female phenotype

Index to Diseases and Injuries

References found for the code 758.81 in the Index of Diseases and Injuries:

Information for Patients

Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine

[Read More]

ICD-9 Footnotes

General Equivalence Map Definitions
The ICD-9 and ICD-10 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Index of Diseases and Injuries Definitions

  • And - The word "and" should be interpreted to mean either "and" or "or" when it appears in a title.
  • Code also note - A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • Code first - Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • Type 1 Excludes Notes - A type 1 Excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Type 2 Excludes Notes - A type 2 Excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • Includes Notes - This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
  • Inclusion terms - List of terms is included under some codes. These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • NEC "Not elsewhere classifiable" - This abbreviation in the Alphabetic Index represents "other specified". When a specific code is not available for a condition, the Alphabetic Index directs the coder to the "other specified” code in the Tabular List.
  • NOS "Not otherwise specified" - This abbreviation is the equivalent of unspecified.
  • See - The "see" instruction following a main term in the Alphabetic Index indicates that another term should be referenced. It is necessary to go to the main term referenced with the "see" note to locate the correct code.
  • See Also - A "see also" instruction following a main term in the Alphabetic Index instructs that there is another main term that may also be referenced that may provide additional Alphabetic Index entries that may be useful. It is not necessary to follow the "see also" note when the original main term provides the necessary code.
  • 7th Characters - Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
  • With - The word "with" should be interpreted to mean "associated with" or "due to" when it appears in a code title, the Alphabetic Index, or an instructional note in the Tabular List. The word "with" in the Alphabetic Index is sequenced immediately following the main term, not in alphabetical order.