Version 2024

2024 ICD-10-CM Diagnosis Code T80.5

Anaphylactic reaction due to serum

ICD-10-CM Code:
T80.5
ICD-10 Code for:
Anaphylactic reaction due to serum
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Complications of surgical and medical care, not elsewhere classified
      (T80-T88)
      • Complications following infusion, transfusion and therapeutic injection
        (T80)

T80.5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of anaphylactic reaction due to serum. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Anaphylactic reaction due to serum

Non-specific codes like T80.5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for anaphylactic reaction due to serum:

  • T80.51 for Anaphylactic reaction due to administration of blood and blood products - NON-BILLABLE CODE

  • Use T80.51XA for initial encounter - BILLABLE CODE

  • Use T80.51XD for subsequent encounter - BILLABLE CODE

  • Use T80.51XS for sequela - BILLABLE CODE

  • T80.52 for Anaphylactic reaction due to vaccination - NON-BILLABLE CODE

  • Use T80.52XA for initial encounter - BILLABLE CODE

  • Use T80.52XD for subsequent encounter - BILLABLE CODE

  • Use T80.52XS for sequela - BILLABLE CODE

  • T80.59 for Anaphylactic reaction due to other serum - NON-BILLABLE CODE

  • Use T80.59XA for initial encounter - BILLABLE CODE

  • Use T80.59XD for subsequent encounter - BILLABLE CODE

  • Use T80.59XS for sequela - BILLABLE CODE

Coding Guidelines

The appropriate 7th character is to be added to each code from block Complications following infusion, transfusion and therapeutic injection (T80). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • ABO incompatibility reaction due to transfusion of blood or blood products T80.3
  • allergic reaction or shock NOS T78.2
  • anaphylactic reaction or shock NOS T78.2
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered T88.6
  • other serum reaction T80.6

Patient Education


Anaphylaxis

Anaphylaxis is a serious allergic reaction. It can begin very quickly, and symptoms may be life-threatening. The most common causes are reactions to foods (especially peanuts), medications, and stinging insects. Other causes include exercise and exposure to latex. Sometimes no cause can be found.

It can affect many organs:

  • Skin - itching, hives, redness, swelling
  • Nose - sneezing, stuffy nose, runny nose
  • Mouth - itching, swelling of the lips or tongue
  • Throat - itching, tightness, trouble swallowing, swelling of the back of the throat
  • Chest - shortness of breath, coughing, wheezing, chest pain or tightness
  • Heart - weak pulse, passing out, shock
  • Gastrointestinal tract - vomiting, diarrhea, cramps
  • Nervous system - dizziness or fainting

If someone is having a serious allergic reaction, call 911. If an auto-injector is available, give the person the injection right away.


[Learn More in MedlinePlus]

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.