2024 ICD-10-CM Diagnosis Code T44.4X5S

Adverse effect of predominantly alpha-adrenoreceptor agonists, sequela

ICD-10-CM Code:
T44.4X5S
ICD-10 Code for:
Adverse effect of predom alpha-adrenocpt agonists, sequela
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system
        (T44)

T44.4X5S is a billable diagnosis code used to specify a medical diagnosis of adverse effect of predominantly alpha-adrenoreceptor agonists, sequela. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T44.4X5S is a sequela code, includes a 7th character and should be used for complications that arise as a direct result of a condition like adverse effect of predominantly alpha-adrenoreceptor agonists. According to ICD-10-CM Guidelines a "sequela" code should be used for chronic or residual conditions that are complications of an initial acute disease, illness or injury. The most common sequela is pain. Usually, two diagnosis codes are needed when reporting sequela. The first code describes the nature of the sequela while the second code describes the sequela or late effect.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction caused by decongestant
  • Alpha-adrenoceptor agonist adverse reaction
  • Amphetamine group adverse reaction
  • Apraclonidine adverse reaction
  • Central alpha-2 adrenergic receptor agonist adverse reaction
  • Metaraminol adverse reaction
  • Methoxamine adverse reaction
  • Norepinephrine adverse reaction
  • Oxedrine tartrate adverse reaction
  • Phenylephrine adverse reaction
  • Vasopressor adverse reaction

Clinical Classification

Clinical Information

  • Etilefrine

    a phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.
  • Metaraminol

    a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. it has been used primarily as a vasoconstrictor in the treatment of hypotension.
  • Methoxamine

    an alpha-1 adrenergic agonist that causes prolonged peripheral vasoconstriction.
  • Norepinephrine

    precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the locus ceruleus. it is also found in plants and is used pharmacologically as a sympathomimetic.
  • Norepinephrine Plasma Membrane Transport Proteins

    sodium chloride-dependent neurotransmitter symporters located primarily on the plasma membrane of noradrenergic neurons. they remove norepinephrine from the extracellular space by high affinity reuptake into presynaptic terminals. the norepinephrine transporter regulates signal amplitude and duration at noradrenergic synapses and is the target of adrenergic uptake inhibitors.
  • Phenylethanolamine N-Methyltransferase

    a methyltransferase that catalyzes the reaction of s-adenosyl-l-methionine and phenylethanolamine to yield s-adenosyl-l-homocysteine and n-methylphenylethanolamine. it can act on various phenylethanolamines and converts norepinephrine into epinephrine. (from enzyme nomenclature, 1992) ec 2.1.1.28.
  • Receptors, Adrenergic

    cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. the two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. adrenergic receptors may also be classified according to the subtypes of g-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
  • Phenylephrine

    an alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (T44). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)

T44.4X5S is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert T44.4X5S to ICD-9-CM

  • ICD-9-CM Code: 909.5 - Lte efct advrs efct drug
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.
  • ICD-9-CM Code: E941.2 - Adv eff sympathomimetics
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.

Table of Drugs and Chemicals

The parent code T44.4X5 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AgonistT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
Agonist
  »predominantly
T44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
Agonist
  »predominantly
    »alpha-adrenoreceptor
T44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
Agonist
  »predominantly
    »beta-adrenoreceptor
T44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
AplonidineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
Apraclonidine (hydrochloride)T44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
CyclopentamineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
EtilefrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
GepefrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
LevarterenolT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
MetaraminolT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
MethoxamineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
NoradrenalineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
NorepinephrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
NorfenefrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
OxedrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
ParedrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
PhenylephrineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6
PrivineT44.4X1T44.4X2T44.4X3T44.4X4T44.4X5T44.4X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.