2024 ICD-10-CM Diagnosis Code T37.2X5S

Adverse effect of antimalarials and drugs acting on other blood protozoa, sequela

ICD-10-CM Code:
T37.2X5S
ICD-10 Code for:
Advrs effect of antimalari/drugs acting on bld protzoa, sqla
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics
        (T37)

T37.2X5S is a billable diagnosis code used to specify a medical diagnosis of adverse effect of antimalarials and drugs acting on other blood protozoa, sequela. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T37.2X5S is a sequela code, includes a 7th character and should be used for complications that arise as a direct result of a condition like adverse effect of antimalarials and drugs acting on other blood protozoa. According to ICD-10-CM Guidelines a "sequela" code should be used for chronic or residual conditions that are complications of an initial acute disease, illness or injury. The most common sequela is pain. Usually, two diagnosis codes are needed when reporting sequela. The first code describes the nature of the sequela while the second code describes the sequela or late effect.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction to Cinchona alkaloid
  • Adverse reaction to Cinchona alkaloid
  • Adverse reaction to cycloguanil
  • Adverse reaction to sulfadoxine and pyrimethamine
  • Aminoquinoline antimalarial adverse reaction
  • Aminoquinoline antimalarial adverse reaction
  • Amodiaquine adverse reaction
  • Antimalarial drug adverse reaction
  • Biguanide adverse reaction
  • Biguanide adverse reaction
  • Biguanide antimalarial adverse reaction
  • Bilateral toxic maculopathy
  • Chloroquine adverse reaction
  • Chloroquine adverse reaction
  • Chloroquine myopathy
  • Chloroquine retinopathy
  • Halofantrine adverse reaction
  • Hemolytic anemia due to drugs
  • Left toxic maculopathy
  • Mefloquine adverse reaction
  • Mepacrine adverse reaction
  • Post-artesunate delayed hemolysis
  • Primaquine adverse reaction
  • Primaquine sensitivity anemia
  • Proguanil adverse reaction
  • Pruritus caused by antimalarial
  • Pruritus caused by drug
  • Pyrimethamine adverse reaction
  • Quinine adverse reaction
  • Quinine adverse reaction
  • Quinine retinopathy
  • Right toxic maculopathy
  • Toxic maculopathy
  • Toxic maculopathy due to antimalarial drug

Clinical Classification

Clinical Information

  • Amodiaquine

    a 4-aminoquinoline compound with anti-inflammatory properties.
  • Chloroquine

    the prototypical antimalarial agent with a mechanism that is not well understood. it has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
  • Cinchona

    a genus of rubiaceous south american trees that yields the toxic cinchona alkaloids from their bark; quinine; quinidine; chinconine, cinchonidine and others are used to treat malaria and cardiac arrhythmias.
  • Cinchona Alkaloids

    alkaloids extracted from various species of cinchona.
  • Eflornithine

    an inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
  • Mefloquine

    a phospholipid-interacting antimalarial drug (antimalarials). it is very effective against plasmodium falciparum with very few side effects.
  • Primaquine

    an aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. it has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. adverse effects include anemias and gi disturbances. (from martindale, the extra pharmacopeia, 30th ed, p404)
  • Proguanil

    a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
  • Pyrimethamine

    one of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
  • Quinacrine

    an acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. it has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. it is used in cell biological experiments as an inhibitor of phospholipase a2.
  • Quinacrine Mustard

    nitrogen mustard analog of quinacrine used primarily as a stain in the studies of chromosomes and chromatin. fluoresces by reaction with nucleic acids in chromosomes.
  • Quinine

    an alkaloid derived from the bark of the cinchona tree. it is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. it was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. the mechanisms of its antimalarial effects are not well understood.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (T37). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)

T37.2X5S is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert T37.2X5S to ICD-9-CM

  • ICD-9-CM Code: 909.5 - Lte efct advrs efct drug
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.
  • ICD-9-CM Code: E931.4 - Adv eff antimalarials
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.

Table of Drugs and Chemicals

The parent code T37.2X5 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
8-Aminoquinoline drugsT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AmodiaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Amopyroquin (e)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AntimalarialT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Antimalarial
  »prophylactic NEC
T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Antimalarial
  »pyrimidine derivative
T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
AralenT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
CamoquinT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChloroguanideT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChloroquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ChlorproguanilT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
CinchonaT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Cinchonine alkaloidsT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Cycloguanil embonateT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
DaraprimT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
EflornithineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
GuanatolT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
HalofantrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
IsopentaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
MefloquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
MepacrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PaludrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Pamaquine (naphthoute)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PentaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PrimaquineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
ProguanilT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
PyrimethamineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Pyrimethamine
  »with sulfadoxine
T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinacrineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinineT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
QuinocideT37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6
Schizontozide (blood) (tissue)T37.2X1T37.2X2T37.2X3T37.2X4T37.2X5T37.2X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.