2024 ICD-10-CM Diagnosis Code M35.9

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Acquired poikiloderma
• Acquired sensorineural hearing loss
• Associated pulmonary arterial hypertension
• Autoimmune connective tissue disorder
• Autoimmune disease
• Autoimmune disorder of autonomic nerve
• Autoimmune disorder of autonomic nervous system
• Autoimmune esophagitis
• Autoimmune ganglionopathy
• Autoimmune inflammation of skeletal muscle
• Autoimmune leukopenia
• Autoimmune necrotizing myopathy
• Autoimmune opsoclonus myoclonus
• Autoimmune optic neuropathy
• Autoimmune pancytopenia
• Autoimmune sensorineural hearing loss
• Autoimmune skin disease
• Cardiomyopathy due to connective tissue disease
• Chronic tubulo-interstitial nephritis due to connective tissue disorder
• Collagen and elastic tissue disorders affecting skin
• Collagen disease
• Congenital connective tissue disorder
• Conjunctivitis associated with autoimmune skin disorder
• Connective tissue disease overlap syndrome
• Connective tissue hereditary disorder
• Dilated cardiomyopathy with connective tissue disorder
• Disorder of connective tissue co-occurrent and due to systemic disease
• Disseminated eosinophilic collagen disease
• Fetal disorder due to maternal autoimmune disease
• Idiopathic inflammatory myopathy
• Immune neutropenia
• Immunoglobulin G4 related disease
• Immunoglobulin G4 related disease
• Immunoglobulin G4 related kidney disease
• Immunoglobulin G4 related ophthalmic disease
• Interstitial lung disease due to collagen vascular disease
• Interstitial lung disease due to connective tissue disease
• Lung disease due to connective tissue disorder
• Lung disease due to connective tissue disorder
• Lung disorder due to autoimmune disorder
• Metabolic disease of collagen
• Mixed collagen vascular disease
• Myocarditis due to autoimmune disease
• Necrotizing vasculitis secondary to connective tissue disease
• Neutropenia associated with autoimmune disease
• Noninfectious enteritis due to autoimmune disease
• Non-infectious ulceration of small intestine due to autoimmune disease
• Non-infective ulceration of small intestine
• Opsoclonus-myoclonus syndrome
• Overlap syndrome
• Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection
• Pericarditis secondary to collagen vascular disease
• Photodermatitis co-occurrent and due to autoimmune disease
• Poikiloderma due to connective tissue disease
• Polymyositis
• Polymyositis associated with autoimmune disease
• Polyneuropathy co-occurrent and due to systemic connective tissue disorder
• Polyneuropathy in collagen vascular disease
• Primary ITP
• Pulmonary arterial hypertension associated with connective tissue disease
• Raynaud phenomenon due to autoimmune disease
• Raynaud's phenomenon
• Renal tubulo-interstitial disorders in systemic connective tissue disorders
• Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
• Secondary anetoderma
• Secondary Raynaud's phenomenon
• Small vessel cerebrovascular disease
• Xerostomia
• Xerostomia due to autoimmune disease

Clinical Information

• Dermatomyositis

  a subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. the illness occurs with approximately equal frequency in children and adults. the skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. the disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. the childhood form of this disease tends to evolve into a systemic vasculitis. dermatomyositis may occur in association with malignant neoplasms. (from adams et al., principles of neurology, 6th ed, pp1405-6)

• Polymyositis

  diseases characterized by inflammation involving multiple muscles. this may occur as an acute or chronic condition associated with medication toxicity (drug toxicity); connective tissue diseases; infections; malignant neoplasms; and other disorders. the term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. the illness may occur at any age, but is most frequent in the fourth to sixth decade of life. weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (adams et al., principles of neurology, 6th ed, pp1404-9)

• Xerostomia

  decreased salivary flow.

• Exosome Component 10|Autoantigen PM-SCL|Autoantigen PM/Scl|EC 3.1.13.-|EXOSC10|P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen|PM/Scl-100|Polymyositis/Scleroderma Autoantigen 100 kDa|Polymyositis/Scleroderma Autoantigen 2

  exosome component 10 (885 aa, ~101 kda) is encoded by the human exosc10 gene. this protein plays a role in the maturation and degradation of rna.

• Other Overlap Syndromes|Other overlap syndromes

  evidence of other overlap syndromes not specified elsewhere.

• Overlap Syndrome

  an autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. these typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and sjogren syndrome; in pediatrics the respective pediatric entities are encountered.

• Scleroderma Polymyositis Overlap Syndrome|Scleroderma Polymyositis

  a rare autoimmune disorder in which patients present with overlapping symptoms of systemic scleroderma and polymyositis or dermatomyositis.

M35.9 is grouped with Diagnostic Related Groups - MS-DRG Mapping

Diagnostic Related Groups (DRGs) are a classification system used to group together diagnosis codes for the purpose of reimbursement and healthcare management. DRGs are used to standardize the way hospitals and other providers are paid for inpatient services. In this system patients are grouped together based on their principal diagnosis in areas referred to as Major Diagnostic Categories (MDC). Once a patient is assigned a particular diagnostic category, providers receive a predetermined payment rate for the services rendered. This reimbursement rate is often fixed and is meant to cover the cost of care for that patient. Reimbursement is also affected by the relative weight of a diagnostic related group based on the severity of a patient's illness and the associated cost of care during hospitalization.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V41.0 applicable from 10/01/2023 through 09/30/2024.

MS-DRG	MS-DRG Title	MCD	Relative Weight
545	CONNECTIVE TISSUE DISORDERS WITH MCC	08	2.4932
546	CONNECTIVE TISSUE DISORDERS WITH CC	08	1.1993
547	CONNECTIVE TISSUE DISORDERS WITHOUT CC/MCC	08	0.8134

The relative weight of a diagnostic related group determines the reimbursement rate based on the severity of a patient's illness and the associated cost of care during hospitalization.

Convert M35.9 to ICD-9-CM

• ICD-9-CM Code: 710.9 - Diff connect tis dis NOS
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education

Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Over 200 disorders that impact connective tissue. There are different types:

• Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta
• Autoimmune disorders, such as lupus and scleroderma
• Cancers, like some types of soft tissue sarcoma

Each disorder has its own symptoms and needs different treatment.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

[Learn More in MedlinePlus]

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.