- ICD-10 Index
- Chapter: G00–G99
- Section: G10-G14
- Spinal muscular atrophy and related syndromes (G12)
Clinical Terms for Spinal muscular atrophy and related syndromes (G12)
Spinal Muscular Atrophy-. A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary.
Motor Neuron Disease-. Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation.
Amyotrophic Lateral Sclerosis-. A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts.
Bulbar Palsy, Progressive-. A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults.
Diseases of the nervous system (G00–G99)
Systemic atrophies primarily affecting the central nervous system (G10-G14)
- G12 - Spinal muscular atrophy and related syndromes NON-BILLABLE CODE
- G12.0 - Infantile spinal muscular atrophy, type I [Werdnig-Hoffman] BILLABLE CODE
- G12.1 - Other inherited spinal muscular atrophy BILLABLE CODE
- G12.2 - Motor neuron disease NON-BILLABLE CODE
- G12.20 - Motor neuron disease, unspecified BILLABLE CODE
- G12.21 - Amyotrophic lateral sclerosis BILLABLE CODE
- G12.22 - Progressive bulbar palsy BILLABLE CODE
- G12.23 - Primary lateral sclerosis BILLABLE CODE
- G12.24 - Familial motor neuron disease BILLABLE CODE
- G12.25 - Progressive spinal muscle atrophy BILLABLE CODE
- G12.29 - Other motor neuron disease BILLABLE CODE
- G12.8 - Other spinal muscular atrophies and related syndromes BILLABLE CODE
- G12.9 - Spinal muscular atrophy, unspecified BILLABLE CODE
Spinal muscular atrophy and related syndromes (G12)