Malignant immunoproliferative diseases and certain other B-cell lymphomas (C88)
Clinical Information
Heavy Chain Disease - A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Immunoproliferative Small Intestinal Disease - A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.
Waldenstrom Macroglobulinemia - A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.
Instructional Notations
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- B-cell lymphoma, unspecified C85.1
- personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues Z85.79
Neoplasms (C00–D49)
Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
C88 Malignant immunoproliferative diseases and certain other B-cell lymphomas
- C88.0 Waldenstrom macroglobulinemia
- C88.2 Heavy chain disease
- C88.3 Immunoproliferative small intestinal disease
- C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
- C88.8 Other malignant immunoproliferative diseases
- C88.9 Malignant immunoproliferative disease, unspecified
Malignant immunoproliferative diseases and certain other B-cell lymphomas (C88)