2024 ICD-10-CM Diagnosis Code E88.89

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Adenosine deaminase overproduction
• Angioedema due to disorder of kinin metabolism
• Aromatase excess syndrome
• Arylsulfatase deficiency without MLD
• Autosomal recessive ataxia due to ubiquinone deficiency
• Brunner syndrome
• Cerebral folate transport deficiency
• Chronic diarrhea due to glucoamylase deficiency
• Chronic diarrhea of infants AND/OR young children
• Chronic diarrhea of infants AND/OR young children
• Chronic infantile diarrhea due to guanylate cyclase 2C overactivity
• Circulating enzyme deficiency
• Clinical manifestation of enzyme deficiency
• Coenzyme Q10 deficiency
• Complete deficiency of methylmalonyl-CoA mutase
• Congenital defect of folate absorption
• Corticosteroid 11-reductase deficiency
• CYP2B6 poor metabolizer
• CYP2B6 rapid metabolizer
• CYP2B6 ultra-rapid metabolizer
• CYP2C19 poor metabolizer
• CYP2C19 ultra-rapid metabolizer
• CYP2C9 poor metabolizer
• CYP2D6 poor metabolizer
• CYP2D6 ultra-rapid metabolizer
• CYP3A5 poor metabolizer
• Cytochrome p450 CYP1A2 enzyme deficiency
• Cytochrome p450 CYP2E1 enzyme deficiency
• Cytochrome p450 CYP3A enzyme deficiency
• Cytochrome p450 enzyme deficiency
• Cytosolic acetoacetyl-CoA thiolase deficiency
• Decreased metabolic requirement
• Decreased oxygen affinity
• Deficiency of 1,3-beta-glucan synthase
• Deficiency of 1,4-alpha-glucan 6alpha-glucosyltransferase
• Deficiency of 1,4-alpha-glucan branching enzyme
• Deficiency of 2,5-diaminovalerate aminotransferase
• Deficiency of -20-hydroxysteroid dehydrogenase
• Deficiency of -2-hydroxy-acid oxidase
• Deficiency of 3alpha-hydroxycholanate dehydrogenase
• Deficiency of 3-mercaptopyruvate sulfurtransferase
• Deficiency of 3-oxoacid CoA-transferase
• Deficiency of 3-oxoadipate CoA-transferase
• Deficiency of acetate kinase
• Deficiency of acetylcholinesterase
• Deficiency of acetyl-CoA acetyltransferase
• Deficiency of acetyl-CoA acetyltransferase
• Deficiency of acetylesterase
• Deficiency of acid-ammonia ligase
• Deficiency of aconitate hydratase
• Deficiency of adenosine kinase
• Deficiency of adenosinetriphosphatase
• Deficiency of adenylate kinase
• Deficiency of adenylylsulfate kinase
• Deficiency of ADP deaminase
• Deficiency of alcohol sulfotransferase
• Deficiency of aldehyde dehydrogenase
• Deficiency of aldehyde oxidase
• Deficiency of aldehyde-lyase
• Deficiency of alkaline phosphatase
• Deficiency of alkaline phosphomonoesterase
• Deficiency of alkylhalidase
• Deficiency of alpha- and beta-trypsin
• Deficiency of alpha-1,4-glucan-protein synthase
• Deficiency of alpha-aminoacylpeptide hydrolase
• Deficiency of alpha-ketoglutarate dehydrogenase
• Deficiency of amidase
• Deficiency of amidinotransferase
• Deficiency of amidophosphoribosyltransferase
• Deficiency of amine oxidase
• Deficiency of amine oxidase
• Deficiency of aryl sulfotransferase
• Deficiency of arylamine acetyltransferase
• Deficiency of arylesterase
• Deficiency of aspartic proteinase
• Deficiency of ATP pyrophosphatase
• Deficiency of azobenzene reductase
• Deficiency of benzoylcholinesterase
• Deficiency of butyrate-acetoacetate CoA-transferase
• Deficiency of butyrylcholinesterase
• Deficiency of carbamate kinase
• Deficiency of carbon-carbon lyase
• Deficiency of carbon-halide lyase
• Deficiency of carbon-nitrogen lyase
• Deficiency of carbon-oxygen lyase
• Deficiency of carbon-sulfur lyase
• Deficiency of carboxylesterase
• Deficiency of carboxylic ester hydrolase
• Deficiency of catechol oxidase
• Deficiency of cathepsin C
• Deficiency of cathepsin D
• Deficiency of cellulase
• Deficiency of chlorophyllase
• Deficiency of choline acetyltransferase
• Deficiency of choline kinase
• Deficiency of choline-phosphate cytidylyltransferase
• Deficiency of cholinephosphotransferase
• Deficiency of chymosin
• Deficiency of chymotrypsin
• Deficiency of chymotrypsin A and B
• Deficiency of citrate-synthase
• Deficiency of creatine kinase
• Deficiency of D-2-hydroxy-acid dehydrogenase
• Deficiency of dehydrogenase
• Deficiency of dehydrogluconate dehydrogenase
• Deficiency of dehydrogluconokinase
• Deficiency of deoxyribonuclease I
• Deficiency of deoxyribonuclease II
• Deficiency of dephospho-CoA kinase
• Deficiency of dextranase
• Deficiency of dihydroorotase
• Deficiency of diisopropyl-fluorophosphatase
• Deficiency of dimethylallyltranstransferase
• Deficiency of dioxygenase
• Deficiency of dipeptidase
• Deficiency of dipeptide hydrolase
• Deficiency of dipeptidylpeptide hydrolase
• Deficiency of diphosphomevalonate decarboxylase
• Deficiency of diphosphoric monoester hydrolase
• Deficiency of DNA nucleotidylexotransferase
• Deficiency of DNA-directed DNA polymerase
• Deficiency of DNA-directed RNA polymerase
• Deficiency of endopeptidase
• Deficiency of endoribonuclease
• Deficiency of enolase
• Deficiency of enteropeptidase
• Deficiency of epimerase
• Deficiency of erythritol kinase
• Deficiency of estradiol 6beta-monooxygenase
• Deficiency of ethanolamine-phosphate cytidylyltransferase
• Deficiency of ethanolaminephosphotransferase
• Deficiency of ether hydrolase
• Deficiency of exoribonuclease
• Deficiency of FMN adenylyltransferase
• Deficiency of formaldehyde dehydrogenase
• Deficiency of formamidase
• Deficiency of formate dehydrogenase
• Deficiency of formate-tetrahydrofolate ligase
• Deficiency of formiminotetrahydrofolate cyclodeaminase
• Deficiency of formyltetrahydrofolate deformylase
• Deficiency of fumarate hydratase
• Deficiency of fumarylacetoacetase
• Deficiency of galactonolactone dehydrogenase
• Deficiency of glucosamine acetyltransferase
• Deficiency of glucosamine kinase
• Deficiency of glucosamine-phosphate acetyltransferase
• Deficiency of glutathione reductase
• Deficiency of glycerate kinase
• Deficiency of glycerol-3-phosphate acyltransferase
• Deficiency of glycerophosphatase
• Deficiency of glycogen synthase a kinase
• Deficiency of guanine deaminase
• Deficiency of guanylate cyclase 2C
• Deficiency of halogenase
• Deficiency of heparin lyase
• Deficiency of hexose oxidase
• Deficiency of hexosyltransferase
• Deficiency of histidinol dehydrogenase
• Deficiency of hyaluronate lyase
• Deficiency of hyaluronoglucosaminidase
• Deficiency of hydrogen-sulfide acetyltransferase
• Deficiency of hydrolase
• Deficiency of hydrolyase
• Deficiency of hydroxyacylglutathione hydrolase
• Deficiency of hydroxyalkyl-protein kinase
• Deficiency of hydroxymethylglutaryl-CoA hydrolase
• Deficiency of hydroxymethylglutaryl-CoA reductase
• Deficiency of hydroxymethylglutaryl-CoA synthase
• Deficiency of imidodipeptidase
• Deficiency of iminodipeptidase
• Deficiency of IMP cyclohydrolase
• Deficiency of IMP dehydrogenase
• Deficiency of inorganic pyrophosphatase
• Deficiency of inosinase
• Deficiency of isobutyryl-CoA dehydrogenase
• Deficiency of isocitrate lyase
• Deficiency of isomerase
• Deficiency of isopentenyl-diphosphate delta-isomerase
• Deficiency of ketotetrose-phosphate aldolase
• Deficiency of lactonase
• Deficiency of lactoylglutathione lyase
• Deficiency of L-arabinose dehydrogenase
• Deficiency of lecithinase D
• Deficiency of leucine aminopeptidase
• Deficiency of leukotriene C4 synthase
• Deficiency of L-gulonate dehydrogenase
• Deficiency of lichenase
• Deficiency of ligase
• Deficiency of limit dextrinase
• Deficiency of lipophosphodiesterase II
• Deficiency of L-prolylglycine dipeptidase
• Deficiency of lyase
• Deficiency of lysine-tRNA ligase
• Deficiency of lysolecithin acylmutase
• Deficiency of lysophospholipase
• Deficiency of lysozyme
• Deficiency of malate dehydrogenase
• Deficiency of malate dehydrogenase
• Deficiency of malate dehydrogenase
• Deficiency of malate oxidase
• Deficiency of mannitol dehydrogenase
• Deficiency of mannose-6-phosphate isomerase
• Deficiency of metallocarboxypeptidase
• Deficiency of metalloproteinase
• Deficiency of methenyltetrahydrofolate cyclohydrolase
• Deficiency of methylaspartate mutase
• Deficiency of methylenetetrahydrofolate dehydrogenase
• Deficiency of methylglutaconyl-CoA hydratase
• Deficiency of methylmalonyl-CoA mutase
• Deficiency of methyltransferase
• Deficiency of mevaldate reductase
• Deficiency of mevalonate kinase
• Deficiency of monodehydroascorbate reductase
• Deficiency of monooxygenase
• Deficiency of mutase
• Deficiency of myo-inositol oxygenase
• Deficiency of N-acetyl-beta-glucosaminidase
• Deficiency of N-acetylneuraminate lyase
• Deficiency of NAD
• Deficiency of NAD^+^ kinase
• Deficiency of NAD^+^ nucleosidase
• Deficiency of NAD^+^ nucleosidase
• Deficiency of NAD^+^ synthase
• Deficiency of NAD^+^ transhydrogenase
• Deficiency of NADase
• Deficiency of NADH dehydrogenase
• Deficiency of nicotinamide methyltransferase
• Deficiency of nicotinamide phosphoribosyltransferase
• Deficiency of nicotinamide-nucleotide adenylyltransferase
• Deficiency of nicotinate dehydrogenase
• Deficiency of nicotinate phosphoribosyltransferase
• Deficiency of nitrate reductase
• Deficiency of nucleosidase
• Deficiency of nucleoside-diphosphatase
• Deficiency of nucleoside-diphosphate kinase
• Deficiency of nucleoside-phosphate kinase
• Deficiency of nucleotidase
• Deficiency of nucleotide pyrophosphatase
• Deficiency of nucleotidyltransferase
• Deficiency of omega peptidase
• Deficiency of orotate phosphoribosyltransferase
• Deficiency of oxalate CoA-transferase
• Deficiency of oxidase
• Deficiency of oximinotransferase
• Deficiency of oxo-acid-lyase
• Deficiency of oxoglutarate dehydrogenase
• Deficiency of oxygenase
• Deficiency of pancreatic elastase
• Deficiency of pantetheine kinase
• Deficiency of pantetheine-phosphate adenylyltransferase
• Deficiency of pantothenoylcysteine decarboxylase
• Deficiency of pectin methoxylase
• Deficiency of pectin methylesterase
• Deficiency of pectinesterase
• Deficiency of pentosyltransferase
• Deficiency of pepsin A
• Deficiency of pepsin B
• Deficiency of peptidase a
• Deficiency of peptide hydrolase
• Deficiency of peptidoglycan endopeptidase
• Deficiency of peroxidase
• Deficiency of phenylalanine 4-monooxygenase
• Deficiency of phenylpyruvate tautomerase
• Deficiency of phosphatase
• Deficiency of phosphatidate phosphatase
• Deficiency of phosphoacetylglucosamine mutase
• Deficiency of phosphoadenylate 3'-nucleotidase
• Deficiency of phosphoamidase
• Deficiency of phosphoglucomutase
• Deficiency of phosphogluconate dehydrogenase
• Deficiency of phosphogluconate dehydrogenase
• Deficiency of phosphoglycerate mutase
• Deficiency of phosphoketolase
• Deficiency of phospholipase A>2<
• Deficiency of phospholipase C
• Deficiency of phospholipase D
• Deficiency of phosphomevalonate kinase
• Deficiency of phosphomonoesterase
• Deficiency of phosphopantothenate-cysteine ligase
• Deficiency of phosphoprotein phosphatase
• Deficiency of phosphoribokinase
• Deficiency of phosphoribosylamine-glycine ligase
• Deficiency of phosphoribosylglycinamide formyltransferase
• Deficiency of phosphoric diester hydrolase
• Deficiency of phosphoric monoester hydrolase
• Deficiency of phosphorus-oxygen lyase
• Deficiency of phosphorylase kinase
• Deficiency of phosphorylase phosphatase
• Deficiency of phosphotransferase
• Deficiency of plasmin
• Deficiency of polygalacturonase
• Deficiency of polyribonucleotide nucleotidyltransferase
• Deficiency of progesterone 11alpha-monooxygenase
• Deficiency of prolidase
• Deficiency of prolinase
• Deficiency of prolyl dipeptidase
• Deficiency of protease
• Deficiency of protein kinase
• Deficiency of protocatechuate 3,4-dioxygenase
• Deficiency of pyridoxal kinase
• Deficiency of pyridoxamine-phosphate oxidase
• Deficiency of pyrophosphotransferase
• Deficiency of pyrroline-2-carboxylate reductase
• Deficiency of pyruvate kinase
• Deficiency of racemase
• Deficiency of reductase
• Deficiency of renin
• Deficiency of retinal isomerase
• Deficiency of retinyl-palmitate esterase
• Deficiency of riboflavin kinase
• Deficiency of ribokinase
• Deficiency of ribonuclease
• Deficiency of ribose-5-phosphate isomerase
• Deficiency of ribose-phosphate pyrophosphokinase
• Deficiency of ribosomal cathepsin
• Deficiency of ribosomal neutral proteinase
• Deficiency of ribosylnicotinamide kinase
• Deficiency of ribulokinase
• Deficiency of ribulose-phosphate 3-epimerase
• Deficiency of sarcoplasmic reticulum calcium-ATPase 1
• Deficiency of sedoheptulokinase
• Deficiency of serine proteinase
• Deficiency of shikimate dehydrogenase
• Deficiency of sialidase
• Deficiency of squalene monooxygenase
• Deficiency of steroid 17-alpha-monooxygenase
• Deficiency of steroid delta-isomerase
• Deficiency of succinate dehydrogenase
• Deficiency of succinate-CoA ligase
• Deficiency of succinate-CoA ligase
• Deficiency of succinate-CoA ligase
• Deficiency of succinyl-CoA hydrolase
• Deficiency of sulfate adenylyltransferase
• Deficiency of sulfinoalanine decarboxylase
• Deficiency of sulfite reductase
• Deficiency of sulfotransferase
• Deficiency of sulfuric ester hydrolase
• Deficiency of sulfurtransferase
• Deficiency of tannase
• Deficiency of thiamine pyridinylase
• Deficiency of thiamine pyrophosphokinase
• Deficiency of thioethanolamine acetyltransferase
• Deficiency of thioether hydrolase
• Deficiency of thiolester hydrolase
• Deficiency of thiosulfate sulfurtransferase
• Deficiency of thrombin
• Deficiency of transacylase
• Deficiency of transaldolase
• Deficiency of transcarbamoylase
• Deficiency of transcarboxylase
• Deficiency of transferase
• Deficiency of transformiminase
• Deficiency of transformylase
• Deficiency of transketolase
• Deficiency of triacylglycerol lipase
• Deficiency of tripeptide aminopeptidase
• Deficiency of triphosphoric monoester hydrolase
• Deficiency of tropinesterase
• Deficiency of trypsin
• Deficiency of tyraminase
• Deficiency of tyrosine aminotransferase
• Deficiency of UDPglucose dehydrogenase
• Deficiency of unspecific monooxygenase
• Deficiency of uracil dehydrogenase
• Deficiency of uracil phosphoribosyltransferase
• Deficiency of urate oxidase
• Deficiency of uronolactonase
• Deficiency of UTP-glucose-1-phosphate uridylyltransferase
• Deficiency of UTP-hexose-1-phosphate uridylyltransferase
• Deficiency of w-amidase
• Deficiency of xylan endo-1,3-beta-xylosidase
• Deficiency of Zeta-chain associated protein kinase 70
• Diffuse organ or tissue uptake
• Dilated cardiomyopathy due to familial storage disease
• Dilated cardiomyopathy due to lysosomal storage disease
• Dilated cardiomyopathy due to metabolic disorder
• Disorder due to N-acetyltransferase enzyme variant
• Disorder of blood gas
• Disorder of cortisol-cortisone shuttle
• Disorder of iodine metabolism
• Disorder of lysosomal enzyme
• Disorder of organic acid metabolism
• Disorder of oxygen transport
• Disorder of propionate AND/OR methylmalonate metabolism
• Disorder of protein metabolism
• Disorder of sialic acid metabolism
• Disorder of sialic acid metabolism
• Disorder of sialic acid metabolism
• Disorder of steroid metabolism
• DPYD poor metabolizer
• Erythrocyte enzyme deficiency
• Ethanolaminosis
• Etiocholanolone fever
• Fast acetylator due to N-acetyltransferase enzyme variant
• Folic acid deficiency
• Folic acid deficiency
• Folinic acid responsive seizure syndrome
• Fumarase deficiency
• Fumarylacetoacetase deficiency, acute type
• Glucose phosphate isomerase deficiency
• Glutathione S-transferase deficiency
• Gronblad-Strandberg syndrome
• Hyperimidodipeptiduria
• Hypermetabolism
• Hypermethioninemia
• Hyperthermia-hyperphagia-hypothyroidism syndrome
• Hypertrophic cardiomyopathy due to lysosomal disease
• Impaired oxygen delivery
• Impaired oxygen extraction
• Increased auto-oxidation
• Increased metabolic requirement
• Increased oxygen affinity
• Increased oxygen demand
• Inherited disorder of folate metabolism
• Intestinal enteropeptidase deficiency
• Intestinal obstruction in newborn due to guanylate cyclase 2C deficiency
• Ketoacidosis due to monocarboxylate transporter-1 deficiency
• Ketonemia
• Ketosis
• Ketotic hypoglycemia
• Liposynovitis prepatellaris
• Meconium ileus
• Metabolic disorder of transport
• Metabolic myopathy due to lactate transporter defect
• Methylcrotonic aciduria
• Mevalonic aciduria
• Mitochondrial 2-methylacetoacetyl-CoA thiolase deficiency - non-potassium stimulated
• Mucolipidosis
• Muscle D-lactate dehydrogenase deficiency
• NADHX dehydratase deficiency
• NADHX epimerase deficiency
• Neonatal obstruction of intestine
• Non-amino organic acidemia AND/OR aciduria
• NUDT15 intermediate metabolizer
• NUDT15 poor metabolizer
• NUDT15 possible intermediate metabolizer
• Pancreatic colipase deficiency
• Pancreatic malabsorption
• Partial deficiency of methylmalonyl-CoA mutase
• Patchy organ or tissue uptake
• Pentose disorder
• Perinatal intestinal obstruction
• Phosphoglycerokinase deficiency
• Prepatellar bursitis
• Progressive polyneuropathy with bilateral striatal necrosis
• Progressive retinal dystrophy due to retinol transport defect
• Proteinosis
• Pseudohypoaldosteronism
• Pseudohypoaldosteronism type 2A
• Pseudohypoaldosteronism, type 1
• Pseudohypoaldosteronism, type 1, dominant form
• Pseudohypoaldosteronism, type 1, recessive form
• Pseudohypoaldosteronism, type 2
• Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency
• Rowley-Rosenberg syndrome
• S-adenosylhomocysteine hydrolase deficiency
• Short stature, developmental delay, congenital heart defect syndrome
• Sialic acid storage disease, severe infantile type
• Sialic storage disease
• Sialuria
• SLCO1B1 decreased function
• SLCO1B1 poor function
• Slow acetylator due to N-acetyltransferase enzyme variant
• Specific enzyme deficiency
• Steatosis
• Steroid dehydrogenase deficiency and dental anomaly syndrome
• Testosterone 17-beta-dehydrogenase deficiency
• TPMT poor metabolizer
• Transient pseudohypoaldosteronism
• Trypsinogen deficiency
• UGT1A1 poor metabolizer

Clinical Information

• Folic Acid Deficiency

  a nutritional condition produced by a deficiency of folic acid in the diet. many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. alcohol interferes with its intermediate metabolism and absorption. folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. this deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. it is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed)

• Meconium Ileus

  intestinal obstruction caused by congealed meconium in the distal ileum and cecum. it presents shortly after birth as a failure to pass meconium and frequently occurs in infants with cystic fibrosis.

• Diabetes Mellitus, Type 1

  a subtype of diabetes mellitus that is characterized by insulin deficiency. it is manifested by the sudden onset of severe hyperglycemia, rapid progression to diabetic ketoacidosis, and death unless treated with insulin. the disease may occur at any age, but is most common in childhood or adolescence.

• Diabetes Mellitus, Type 2

  a subclass of diabetes mellitus that is not insulin-responsive or dependent (niddm). it is characterized initially by insulin resistance and hyperinsulinemia; and eventually by glucose intolerance; hyperglycemia; and overt diabetes. type ii diabetes mellitus is no longer considered a disease exclusively found in adults. patients seldom develop ketosis but often exhibit obesity.

• Diabetic Ketoacidosis

  a life-threatening complication of diabetes mellitus, primarily of type 1 diabetes mellitus with severe insulin deficiency and extreme hyperglycemia. it is characterized by ketosis; dehydration; and depressed consciousness leading to coma.

• Ketosis

  a condition characterized by an abnormally elevated concentration of ketone bodies in the blood (acetonemia) or urine (acetonuria). it is a sign of diabetes complication, starvation, alcoholism or a mitochondrial metabolic disturbance (e.g., maple syrup urine disease).

• Pseudohypoaldosteronism

  a heterogeneous group of disorders characterized by renal electrolyte transport dysfunctions. congenital forms are rare autosomal disorders characterized by neonatal hypertension, hyperkalemia, increased renin activity and aldosterone concentration. the type i features hyperkalemia with sodium wasting; type ii, hyperkalemia without sodium wasting. pseudohypoaldosteronism can be the result of a defective renal electrolyte transport protein or acquired after kidney transplantation.

• Folic Acid

  a member of the vitamin b family that stimulates the hematopoietic system. it is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

• Hepatic Steatosis|Fatty (change of) liver, not elsewhere classified|Fatty Liver Change|Liver Steatosis

  a morphologic finding indicating intracytoplasmic fat accumulation in the liver parenchyma.

• Macrovesicular Steatosis|Hepatic Macrovesicular Steatosis

  a morphologic finding indicating intracytoplasmic fat accumulation in the liver parenchyma. unlike microvesicular steatosis, the fat accumulation displaces the nucleus of the hepatocytes, creating a characteristic signet-ring appearance.

• Microvesicular Steatosis Assessment|MVSTS|Microvesicular Steatosis|Microvesicular Steatosis

  an evaluation of the presence or degree of crypt architectural damage in a sample.

• Microvesicular Steatosis|Hepatic Microvesicular Steatosis

  a morphologic finding indicating intracytoplasmic fat accumulation in the liver parenchyma. unlike macrovesicular steatosis, the fat accumulation occurs around the nucleus of the hepatocytes, without displacing it.

• Steatosis

  a morphologic finding indicating intracytoplasmic fat accumulation in the liver parenchyma.

• Steatosis Extent|STSEXT|Steatosis Grade

  an evaluation of the amount or degree of steatosis (fatty tissue) in a biological specimen.

• Steatosis Location|STSLOC

  an evaluation of the predominant distribution pattern of steatosis (fatty tissue) in a biological specimen.

• Steatosis|FATTY CHANGE|Fatty Change

  acumulation of adipose tissue in intracytoplasmic or extracellular spaces.

• Cystic Fibrosis with Meconium Ileus

  a congenital metabolic detected in the neonatal period that is characterized by the presence of a meconium ileus. the disease affects the exocrine glands andis inherited as an autosomal trait. the secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production which causes obstruction of passageways (including pancreatic and bile ducts, intestines, and bronchi). the sweat sodium and chloride content are increased. symptoms usually appear in childhood and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather.

• Meconium Ileus

  small intestinal obstruction that results from the impaction of thick meconium in the distal small intestine.

• Idiopathic Ketotic Hypoglycemia|Accelerated Starvation

  ketotic hypoglycemia that usually occurs in young, thin children in association with infection or fasting, and which typically resolves by age 6-8 years.

• Ketotic Hypoglycemia

  a condition in which hypoglycemia is accompanied by ketosis. this condition may be a manifestation of another condition such as glycogen storage disease, ketone utilization defects, growth hormone deficiency, or cortisol deficiency.

• I-Cell Disease|Inclusion-cell Disease|Mucolipidosis Type II

  an inherited lysosomal storage disease characterized by the presence of dense intracytoplasmic inclusions in mesenchymal cells, especially fibroblasts. signs and symptoms include developmental delay, psychomotor deterioration, and growth failure.

• Mucolipidosis

  a group of inherited lysosomal storage diseases characterized by accumulation of lipids and carbohydrates in the tissues, resulting in mental disabilities and skeletal malformations.

• Mucolipidosis Type III Gamma|Mucolipidosis III Gamma

  an autosomal recessive condition caused by mutation(s) in the gnptag gene, encoding n-acetylglucosamine-1-phosphotransferase subunit gamma. it is characterized by a slowing of the growth rate in childhood, joint stiffness, mild cognitive impairment, and cardiorespiratory insufficiency.

• Mucolipidosis Type IIIA

  a lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.

• Mucolipidosis Type IV|Mucolipidosis IV

  an autosomal recessive lysosomal storage disease caused by mutations in the mcoln1 gene. it is characterized by psychomotor developmental delays and ophthalmologic abnormalities.

• Neuraminidase Deficiency|Mucolipidosis I|Sialidosis Type II

  an autosomal recessive inherited lysosomal storage disease characterized by excessive intracellular accumulation and urinary excretion of sialic acid associated with neuraminidase deficiency.

• Coenzyme Q10 Deficiency

  a genetically heterogeneous condition, typically inherited in an autosomal recessive fashion, characterized by coenzyme q10 deficiency.

• Hyperkalemic Mineralocorticoid Resistance|Chloride Shunt Syndrome|Familial Hyperkalemic Hypertension|Gordon Hyperkalemia|Mineralocorticoid Resistant Hyperkalemia|PHA Type 2|Pseudohypoaldosteronism, Type II|Spitzer-Weinstein Syndrome

  a genetically heterogynous condition characterized by hyperkalemia, hyperchloremic acidosis, low or suppressed renin activity, and normal to high concentrations of aldosterone. mutations in genes (for example wnk1 or wnk4), regulating na-cl cotransporters (ncc), na-k-cl cotransporters (nkcc2), or the renal outer medullary potassium (romk) channel have been identified as causative in this condition. the primary abnormality is thought to be a specific defect of the renal secretory mechanism for potassium, which limits the kaliuretic response to, but not the sodium and chloride reabsorptive effect of, mineralocorticoid.

• Hyponatremic Mineralocorticoid Resistance due to Mineralocorticoid Receptor Defect|PHA1AD|Pseudohypoaldosteronism Type I Autosomal Dominant

  an autosomal dominant condition presenting with hyponatremia and hyperkalemia, mimicking low concentrations of aldosterone, associated with loss-of-function mutation(s) in the nr3c2 gene, encoding the mineralocorticoid receptor.

• Pseudohypoaldosteronism

  an inherited or acquired disorder of electrolyte metabolism, characterized by the inability of the renal tubules to respond to aldosterone. it is manifested by hyperkalemic metabolic acidosis, urinary salt wasting, normal or increased aldosterone secretion and normal glomerular filtration rate.

• Pseudohypoaldosteronism Type 1|PHA1B|Pseudohypoaldosteronism Type I Autosomal Recessive

  a hereditary, heterogeneous disorder of electrolyte metabolism that is characterized by renal resistance to aldosterone action, resulting in salt wasting, hypotension, hyperkalemia, and metabolic acidosis.

• Pseudohypoaldosteronism Type 2|Gordon Syndrome

  a hereditary renal tubular defect characterized by hypertension and hyperkalemic metabolic acidosis in the presence of suppressed plasma renin levels and relatively low aldosterone levels.

Convert E88.89 to ICD-9-CM

• ICD-9-CM Code: 272.8 - Lipoid metabol dis NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
• ICD-9-CM Code: 277.89 - Metabolism disorder NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.

A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.

You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.