ICD-10 Diagnosis Code E27.40

Unspecified adrenocortical insufficiency

Diagnosis Code E27.40

ICD-10: E27.40
Short Description: Unspecified adrenocortical insufficiency
Long Description: Unspecified adrenocortical insufficiency
This is the 2018 version of the ICD-10-CM diagnosis code E27.40

Valid for Submission
The code E27.40 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Other disorders of adrenal gland (E27)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code E27.40 is grouped in the following Diagnostic Related Group(s) (MS-DRG V34.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Adrenal cortical hypofunction
  • Adrenal hypofunction
  • Adrenal medullary insufficiency
  • Adrenocorticotropic hormone deficiency
  • Aldosterone deficiency
  • Epinephrine deficiency
  • Familial adrenocortical hypoplasia
  • Hypoadrenalism
  • Hypoadrenergic postural hypotension
  • Idiopathic adrenocorticotropic hormone deficiency
  • Orthostatic hypotension

Index of Diseases and Injuries
References found for the code E27.40 in the Index of Diseases and Injuries:

Information for Patients

Addison Disease

Also called: Adrenal insufficiency, Adrenocortical hypofunction, Hypocortisolism

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • ACTH (cosyntropin) stimulation test (Medical Encyclopedia)
  • ACTH blood test (Medical Encyclopedia)
  • Acute adrenal crisis (Medical Encyclopedia)
  • Addison disease (Medical Encyclopedia)
  • Cortisol level (Medical Encyclopedia)

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