Version 2024
Replaced Code

2024 ICD-10-CM Diagnosis Code E23.0

Hypopituitarism

ICD-10-CM Code:
E23.0
ICD-10 Code for:
Hypopituitarism
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

Code Classification

  • Endocrine, nutritional and metabolic diseases
    (E00–E89)
    • Disorders of other endocrine glands
      (E20-E35)
      • Hypofunction and other disorders of the pituitary gland
        (E23)

E23.0 is a billable diagnosis code used to specify a medical diagnosis of hypopituitarism. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acquired central hypothyroidism
  • Acquired central hypothyroidism due to pituitary disorder
  • Acquired central hypothyroidism due to Sheehan syndrome
  • ACTH deficiency
  • Adult growth hormone deficiency
  • Adult growth hormone deficiency with onset in childhood
  • Adult-onset growth hormone deficiency
  • Alopecia and intellectual disability with hypergonadotropic hypogonadism syndrome
  • Amenorrhea due to congenital gonadotrophin releasing hormone deficiency
  • Anemia of endocrine disorder
  • Anemia of pituitary deficiency
  • Anterior pituitary hormone deficiency
  • Asexual dwarfism
  • Ateleiotic dwarfism
  • Ateliotic dwarfism without insulinopenia
  • Autoimmune hypopituitarism
  • Autosomal dominant isolated somatotropin deficiency
  • Autosomal recessive isolated somatotropin deficiency
  • Avascular necrosis of pituitary gland
  • Axonal neuropathy
  • Cataract, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, skeletal dysplasia syndrome
  • Central hypothyroidism
  • Combined pituitary hormone deficiency genetic form
  • Congenital disorder of facial nerve
  • Congenital facial nerve palsy
  • Congenital hypogonadotropic hypogonadism
  • Congenital hypoplasia of nose
  • Congenital malformation of anterior pituitary
  • Congenital stenosis of carotid artery
  • Deficiency in anterior pituitary function, variable immunodeficiency syndrome
  • Dilated cardiomyopathy with hypergonadotropic hypogonadism syndrome
  • Endocrine myopathy
  • Female hypogonadotropic hypogonadism
  • Female infertility of pituitary - hypothalamic origin
  • Follicle stimulating hormone deficiency
  • Functional hypogonadotropic hypogonadism
  • Gonadotropin releasing factor deficiency
  • Growth hormone deficiency
  • Growth hormone deficiency after bone marrow transplant
  • Growth hormone neurosecretory dysfunction
  • Hereditary growth hormone deficiency
  • Hereditary growth hormone deficiency
  • Hereditary sensory neuropathy
  • Hypergonadotropic hypogonadism with cataract syndrome
  • Hypogonadism with anosmia
  • Hypogonadism with anosmia
  • Hypogonadotropic hypogonadism
  • Hypogonadotropic hypogonadism due to follicle-stimulating hormone deficiency
  • Hypogonadotropic hypogonadism due to isolated gonadotropin deficiency
  • Hypogonadotropic hypogonadism due to isolated gonadotropin deficiency
  • Hypogonadotropic hypogonadism due to luteinizing hormone deficiency
  • Hypogonadotropic hypogonadism retinitis pigmentosa syndrome
  • Hypogonadotropic hypogonadism with frontoparietal alopecia syndrome
  • Hypogonadotropic hypogonadism, severe microcephaly, sensorineural hearing loss, dysmorphism syndrome
  • Hypophysitis
  • Hypopituitarism
  • Hypopituitarism due to granulomatous disease
  • Hypopituitarism due to metabolic disease
  • Hypopituitarism due to pituitary tumor
  • Hypopituitarism due to vascular disorder
  • Hypopituitarism following procedure
  • Hypoplasia of eye
  • Hyposmia, nasal and ocular hypoplasia, hypogonadotropic hypogonadism syndrome
  • Idiopathic growth hormone deficiency
  • Idiopathic hypogonadotropic hypogonadism
  • Idiopathic hypopituitarism
  • Idiopathic panhypopituitarism
  • Immunodeficiency associated with multiple organ system abnormalities
  • Immunodeficiency with major anomalies
  • Immunoglobulinemia with isolated somatotropin deficiency
  • Internal carotid artery stenosis
  • Isolated follicle stimulating hormone deficiency
  • Isolated gonadotropin deficiency
  • Isolated lutropin deficiency
  • Isolated pituitary hormone deficiency
  • Isolated prolactin deficiency
  • Isolated somatotropin deficiency
  • Kallman syndrome with heart disease
  • Late-onset isolated adrenocorticotropic hormone deficiency
  • LH - luteinizing hormone deficiency
  • Loss of sense of smell
  • Loss of sense of smell
  • Lymphocytic hypopituitarism
  • Male hypergonadotropic hypogonadism, intellectual disability, skeletal anomaly syndrome
  • Martsolf syndrome
  • Microcephalus, hypergonadotropic hypogonadism, short stature syndrome
  • Moebius syndrome, axonal neuropathy, hypogonadotropic hypogonadism syndrome
  • Morbid obesity
  • Moyamoya angiopathy, short stature, facial dysmorphism, hypergonadotropic hypogonadism syndrome
  • Moyamoya disease
  • Myopathy in hypopituitarism
  • Necrosis of pituitary
  • Non-acquired combined pituitary hormone deficiency, sensorineural hearing loss, spine abnormalities syndrome
  • Nonfamilial asexual dwarfism
  • Nonfamilial hyperinsulinemic isolated somatotropin deficiency
  • Panhypopituitarism
  • Panhypopituitarism
  • Panhypopituitarism - anterior and posterior
  • Partial growth hormone deficiency
  • Partial hypopituitarism
  • Partial loss of hair
  • Peripheral axonal neuropathy
  • Pituitary cachexia
  • Pituitary deficiency due to empty sella turcica syndrome
  • Pituitary dwarfism
  • Pituitary dwarfism with large sella turcica
  • Pituitary dwarfism with normal somatotropin level AND low somatomedin
  • Pituitary dwarfism with small sella turcica
  • Post-birth injury hypopituitarism
  • Post-infarction hypopituitarism
  • Post-infarction hypopituitarism
  • Post-infarction panhypopituitarism
  • Post-infective hypopituitarism
  • Postpartum hypopituitarism
  • Post-traumatic hypopituitarism
  • Post-traumatic hypopituitarism
  • Post-traumatic hypopituitarism
  • Prepuberal panhypopituitarism
  • Primary hypergonadotropic hypogonadism and partial alopecia syndrome
  • Primary pituitary - hypothalamic infertility
  • Primary testicular failure
  • Proopiomelanocortin deficiency syndrome
  • Psychosocial growth hormone deficiency
  • RAB18 deficiency
  • RHYNS syndrome
  • Secondary hypopituitarism
  • Secondary pituitary - hypothalamic infertility
  • Sensory neuropathy
  • Sequelae of endocrine disorders
  • Sequelae of endocrine disorders
  • Sheehan's syndrome
  • Short stature co-occurrent and due to endocrine disorder
  • Short stature co-occurrent and due to endocrine disorder
  • Short stature co-occurrent and due to endocrine disorder
  • Short stature co-occurrent and due to endocrine disorder
  • Short stature co-occurrent and due to endocrine disorder
  • Short stature co-occurrent and due to endocrine disorder
  • Testicular hypofunction
  • Transient somatotropin deficiency
  • X-linked panhypopituitarism

Clinical Classification

Clinical Information

  • Hypopituitarism

    diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including lh; follicle stimulating hormone; somatotropin; and corticotropin). this may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • Autoimmune Hypophysitis

    immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease).
  • Hypophysitis

    inflammation of the pituitary gland.
  • Moyamoya Disease

    a noninflammatory, progressive occlusion of the intracranial carotid arteries and the formation of netlike collateral arteries arising from the circle of willis. cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. it is characterized by endothelial hyperplasia and fibrosis with thickening of arterial walls. this disease primarily affects children but can also occur in adults.
  • Pituitary Gland

    a small, unpaired gland situated in the sella turcica. it is connected to the hypothalamus by a short stalk which is called the infundibulum.
  • Congenital Facial Nerve Palsy

    partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. it is caused by damage to the seventh cranial nerve.
  • Growth Hormone Neurosecretory Dysfunction

    reduced spontaneous secretion of growth hormone with normal range response to growth hormone provocative stimuli.
  • Autoimmune Hypophysitis|Lymphocytic Hypophysitis

    an autoimmune condition affecting the pituitary gland, characterized by lymphocytic infiltration, commonly presenting with pituitary hormone deficiencies.
  • Grade 1 Hypophysitis, CTCAE|Grade 1 Hypophysitis

    asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  • Grade 2 Hypophysitis, CTCAE|Grade 2 Hypophysitis

    moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental adl
  • Grade 3 Hypophysitis, CTCAE|Grade 3 Hypophysitis

    severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care adl
  • Grade 4 Hypophysitis, CTCAE|Grade 4 Hypophysitis

    life-threatening consequences; urgent intervention indicated
  • Grade 5 Hypophysitis, CTCAE|Grade 5 Hypophysitis

    death
  • Hypophysitis

    an inflammatory process in the pituitary gland.
  • Hypophysitis, CTCAE|Hypophysitis

    a disorder characterized by inflammation and cellular infiltration of the pituitary gland.
  • Lymphocytic Neurohypophysitis

    an autoimmune condition affecting the posterior pituitary gland, which is characterized by lymphocytic infiltration, and which often presents as diabetes insipidus.
  • Morbid Obesity

    an excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight.
  • Pituitary Dwarfism

    proportionately decreased bodily growth due to failure of the pituitary gland to produce an adequate supply of growth hormone.
  • Acute Motor and Sensory Axonal Neuropathy|Acute Motor And Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy

    a subtype of guillain-barre syndrome that targets sensory motor axons, and is characterized by acute onset of quadriparesis, distal sensory loss, areflexia, and respiratory insufficiency.
  • Acute Motor Axonal Neuropathy|AMAN

    a subtype of guillain-barre syndrome that targets motor axons, and is characterized by symmetric limb weakness, diffuse areflexia, facial and oropharyngeal muscle weakness, and respiratory insufficiency.
  • Axonal Neuropathy

    any nerve disorder affecting the axon of a nerve.
  • GAN wt Allele|GAN1|Giant Axonal Neuropathy (Gigaxonin) Gene|Gigaxonin wt Allele|KLHL16

    human gan wild-type allele is located in the vicinity of 16q24.1 and is approximately 65 kb in length. this allele, which encodes gigaxonin protein, is involved in both ubiquitination and neurofilament structure. mutation of the gene is associated with giant axonal neuropathy.
  • Giant Axonal Neuropathy

    a rare inherited disorder affecting the neurofilaments. it is caused by mutations in the gan gene. it is characterized by the presence of abnormally large nerve cell axons. signs and symptoms include difficulty walking, sensory disturbances, lack of motor coordination and abnormal reflexes in the limbs.
  • Spinocerebellar Ataxia, Autosomal Recessive, with Axonal Neuropathy 2|AOA2|Ataxia with Oculomotor Apraxia Type 2|SCAN2

    an autosomal recessive condition caused by mutation(s) in the setx gene, encoding probable helicase senataxin. it is characterized by juvenile onset progressive cerebellar ataxia, axonal sensorimotor peripheral neuropathy, and increased concentrations of serum alpha-fetoprotein. oculomotor apraxia is common, but is not always present.
  • Moyamoya Disease

    a rare inherited vascular disorder characterized by constriction of arteries at the base of the brain, resulting in the formation of collateral circulation in order to compensate for the constriction. the name "moyamoya" in japanese means "puff of smoke" and derives from the characteristic radiographic appearance of the collateral vessels.
  • Moyamoya Disease 2|MYMY2

    an autosomally inherited subtype of moyamoya disease often presenting in childhood caused by mutation(s) in the rnf213 gene, encoding e3 ubiquitin-protein ligase rnf213.
  • RNF213 wt Allele|ALK Lymphoma Oligomerization Partner on Chromosome 17 Gene|ALO17|C17orf27|Chromosome 17 Open Reading Frame 27 Gene|DKFZp762N1115|FLJ13051|KIAA1554|KIAA1618|MGC46622|MGC9929|MYMY2|MYSTR|Moyamoya Disease 2 Gene|NET57|Ring Finger Protein 213 wt Allele|hCG_1812857

    human rnf213 wild-type allele is located in the vicinity of 17q25.3 and is approximately 135 kb in length. this allele, which encodes e3 ubiquitin-protein ligase rnf213 protein, may play a role in the regulation of protein ubiquitination. a chromosomal translocation t(2;17)(p23;q25) of this gene with the alk gene is associated with anaplastic large cell lymphoma.
  • Acquired Central Hypothyroidism

    central hypothyroidism, the cause of which is not present at birth.
  • Congenital Hypogonadotropic Hypogonadism

    insufficient production of estrogen or testosterone in the ovaries or testes due to decreased secretion of gonadotropins as a result of pituitary or hypothalamus gland dysfunction that is present at birth.
  • Isolated Follicle Stimulating Hormone Deficiency

    subnormal concentration of follicle stimulating hormone (fsh), associated with mutations in the fshb gene, encoding follitropin subunit beta.

Replaced Code

This code was replaced in the 2024 ICD-10-CM code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2023. This code was replaced for the FY 2024 (October 1, 2023 - September 30, 2024).


  • G11.5 - Hypomyelination - hypogonadotropic hypogonadism - hypodontia

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Fertile eunuch syndrome
  • Hypogonadotropic hypogonadism
  • Idiopathic growth hormone deficiency
  • Isolated deficiency of gonadotropin
  • Isolated deficiency of growth hormone
  • Isolated deficiency of pituitary hormone
  • Kallmann's syndrome
  • Lorain-Levi short stature
  • Necrosis of pituitary gland (postpartum)
  • Panhypopituitarism
  • Pituitary cachexia
  • Pituitary insufficiency NOS
  • Pituitary short stature
  • Sheehan's syndrome
  • Simmonds' disease

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert E23.0 to ICD-9-CM

  • ICD-9-CM Code: 253.2 - Panhypopituitarism
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 253.3 - Pituitary dwarfism
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 628.1 - Infertil-pituitary orig
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education


Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.


[Learn More in MedlinePlus]

Combined pituitary hormone deficiency

Combined pituitary hormone deficiency is a condition that causes a shortage (deficiency) of several hormones produced by the pituitary gland, which is located at the base of the brain. A lack of these hormones may affect the development of many parts of the body. The first signs of this condition include a failure to grow at the expected rate and short stature that usually becomes apparent in early childhood.

People with combined pituitary hormone deficiency may have hypothyroidism, which is underactivity of the butterfly-shaped thyroid gland in the lower neck. Hypothyroidism can cause many symptoms, including weight gain and fatigue. Other features of combined pituitary hormone deficiency include delayed or absent puberty and lack the ability to have biological children (infertility). The condition can also be associated with a deficiency of the hormone cortisol. Cortisol deficiency can impair the body's immune system, causing individuals to be more susceptible to infection.

Rarely, people with combined pituitary hormone deficiency have intellectual disability; a short, stiff neck; or underdeveloped optic nerves, which carry visual information from the eyes to the brain.


[Learn More in MedlinePlus]

Isolated growth hormone deficiency

Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. Growth hormone is a protein that is necessary for the normal growth of the body's bones and tissues. Because they do not have enough of this hormone, people with isolated growth hormone deficiency commonly experience a failure to grow at the expected rate and have unusually short stature. This condition is usually apparent by early childhood.

There are four types of isolated growth hormone deficiency differentiated by the severity of the condition, the gene involved, and the inheritance pattern.

Isolated growth hormone deficiency type IA is caused by an absence of growth hormone and is the most severe of all the types. In people with type IA, growth failure is evident in infancy as affected babies are shorter than normal at birth.

People with isolated growth hormone deficiency type IB produce very low levels of growth hormone. As a result, type IB is characterized by short stature, but this growth failure is typically not as severe as in type IA. Growth failure in people with type IB is usually apparent in early to mid-childhood.

Individuals with isolated growth hormone deficiency type II have very low levels of growth hormone and short stature that varies in severity. Growth failure in these individuals is usually evident in early to mid-childhood. It is estimated that nearly half of the individuals with type II have underdevelopment of the pituitary gland (pituitary hypoplasia). The pituitary gland is located at the base of the brain and produces many hormones, including growth hormone.

Isolated growth hormone deficiency type III is similar to type II in that affected individuals have very low levels of growth hormone and short stature that varies in severity. Growth failure in type III is usually evident in early to mid-childhood. People with type III may also have a weakened immune system and are prone to frequent infections. They produce very few B cells, which are specialized white blood cells that help protect the body against infection (agammaglobulinemia).


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.