Version 2024

2024 ICD-10-CM Diagnosis Code D61.81

Pancytopenia

ICD-10-CM Code:
D61.81
ICD-10 Code for:
Pancytopenia
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    (D50–D89)
    • Aplastic and other anemias and other bone marrow failure syndromes
      (D60-D64)
      • Other aplastic anemias and other bone marrow failure syndromes
        (D61)

D61.81 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of pancytopenia. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Pancytopenia

Non-specific codes like D61.81 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for pancytopenia:

  • Use D61.810 for Antineoplastic chemotherapy induced pancytopenia - BILLABLE CODE

  • Use D61.811 for Other drug-induced pancytopenia - BILLABLE CODE

  • Use D61.818 for Other pancytopenia - BILLABLE CODE

Clinical Information

  • Pancytopenia

    deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
  • Antineoplastic Chemotherapy Induced Pancytopenia|Antineoplastic chemotherapy induced pancytopenia

    evidence of antineoplastic chemotherapy induced pancytopenia.
  • Ataxia-Pancytopenia Syndrome|ATXPC

    an inherited condition caused by autosomal dominant mutation(s) in the samd9l gene, encoding sterile alpha motif domain-containing protein 9-like. the condition is characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to bone marrow failure and myeloid leukemia.
  • Drug Induced Pancytopenia|Drug-Induced Pancytopenia

    pancytopenia caused by exposure to certain drugs.
  • Fanconi Anemia|Fanconi's Anemia|Fanconi's anemia|Pancytopenia, Congenital|Panmyelopathy, Fanconi|Primary Erythroid Hypoplasia

    an autosomal recessive genetic disorder characterized by bone marrow failure, skeletal abnormalities, and an increased incidence of the development of neoplasias.
  • Other Drug-Induced Pancytopenia|Other drug-induced pancytopenia

    evidence of other drug-induced pancytopenia not specified elsewhere.
  • Other Pancytopenia|Other pancytopenia

    evidence of other pancytopenia not specified elsewhere.
  • Pancytopenia

    a finding of low numbers of red and white blood cells and platelets in the peripheral blood.
  • SAMD9L-Related Ataxia Pancytopenia Syndrome|ATXPC|SAMD9L-ATXPC

    an autosomal dominant inherited syndrome caused by germline mutations of the samd9l gene. it is characterized by cerebellar ataxia, cytopenia in all cell lineages, and predisposition to myelodysplasia and myeloid leukemia.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • pancytopenia due to with aplastic anemia D61.9
  • pancytopenia due to with bone marrow infiltration D61.82
  • pancytopenia due to with congenital pure red cell aplasia D61.01
  • pancytopenia due to with hairy cell leukemia C91.4
  • pancytopenia due to with human immunodeficiency virus disease B20
  • pancytopenia due to with leukoerythroblastic anemia D61.82
  • pancytopenia due to with myeloproliferative disease D47.1

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • pancytopenia due to with myelodysplastic syndromes D46

Patient Education


Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. They can be acute or chronic. Many blood disorders are inherited. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet.

Types of blood disorders include:

  • Platelet disorders, excessive clotting, and bleeding problems, which affect how your blood clots
  • Anemia, which happens when your blood does not carry enough oxygen to the rest of your body
  • Cancers of the blood, such as leukemia and myeloma
  • Eosinophilic disorders, which are problems with one type of white blood cell.

[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.