2024 ICD-10-CM Diagnosis Code C95.90

Leukemia, unspecified not having achieved remission

ICD-10-CM Code:
C95.90
ICD-10 Code for:
Leukemia, unspecified not having achieved remission
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

Code Classification

  • Neoplasms
    (C00–D49)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue
      (C81-C96)
      • Leukemia of unspecified cell type
        (C95)

C95.90 is a billable diagnosis code used to specify a medical diagnosis of leukemia, unspecified not having achieved remission. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Unspecified diagnosis codes like C95.90 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Compound leukemias
  • Gingivitis due to leukemia
  • Leptomeningitis
  • Leukemia
  • Leukemic infiltrate of kidney
  • Leukemic infiltration of skin
  • Malignant white blood cell disorder
  • Meningeal leukemia
  • Periodontitis co-occurrent with hematologic disorder
  • Periodontitis co-occurrent with leukemia
  • Subacute leukemia
  • T-cell leukemic infiltration of skin

Clinical Classification

Clinical Information

  • Abelson murine leukemia virus

    a replication-defective strain of murine leukemia virus (leukemia virus, murine) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with friend murine leukemia virus; moloney murine leukemia virus; or rauscher virus.
  • Anemia, Refractory, with Excess of Blasts

    chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.
  • Burkitt Lymphoma

    a form of undifferentiated malignant lymphoma usually found in central africa, but also reported in other parts of the world. it is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. b-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of burkitt lymphoma. the epstein-barr virus (herpesvirus 4, human) has been isolated from burkitt lymphoma cases in africa and it is implicated as the causative agent in these cases; however, most non-african cases are ebv-negative.
  • Deltaretrovirus

    a genus in the family retroviridae consisting of exogenous horizontally-transmitted viruses found in a few groups of mammals. infections caused by these viruses include human b- or adult t-cell leukemia/lymphoma (leukemia-lymphoma, t-cell, acute, htlv-i-associated), and bovine leukemia (enzootic bovine leukosis). the type species is leukemia virus, bovine.
  • Deltaretrovirus Antibodies

    antibodies reactive with various types of human t-cell leukemia/lymphoma antigens or bovine leukemia virus antigens.
  • Deltaretrovirus Antigens

    antigens associated with the deltaretrovirus; htlv-i antigens and htlv-ii antigens belong to this group.
  • Enzootic Bovine Leukosis

    a lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.
  • HTLV-I Antibodies

    antibodies reactive with the htlv-i antigens.
  • HTLV-I Antigens

    antigens associated with human t-lymphotropic virus 1.
  • HTLV-II Antibodies

    antibodies reactive with the htlv-ii antigens.
  • HTLV-II Antigens

    antigens associated with human t-lymphotropic virus 2.
  • Human T-lymphotropic virus 1

    a strain of primate t-lymphotropic virus 1 isolated from mature t4 cells in patients with t-lymphoproliferation malignancies. it causes adult t-cell leukemia (leukemia-lymphoma, t-cell, acute, htlv-i-associated), t-cell lymphoma (lymphoma, t-cell), and is involved in mycosis fungoides, sezary syndrome and tropical spastic paraparesis (paraparesis, tropical spastic).
  • Human T-lymphotropic virus 2

    a strain of primate t-lymphotropic virus 2 that can transform normal t-lymphocytes and can replicate in both t- and b-cell lines. the virus is related to but distinct from htlv-1.
  • Hypereosinophilic Syndrome

    a heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. there is a massive increase in the number of eosinophils in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.
  • Leukemia

    a progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (from the merck manual, 2006)
  • Leukemia Inhibitory Factor

    an interleukin-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. leukemia inhibitory factor binds to and acts through the lif receptor.
  • Leukemia Inhibitory Factor Receptor alpha Subunit

    a receptor subunit that combines with cytokine receptor gp130 to form the dual specificity receptor for leukemia inhibitory factor and oncostatin m. the subunit is also a component of the ciliary neurotrophic factor receptor. both membrane-bound and secreted isoforms of the receptor subunit exist due to alternative splicing of its mrna. the secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
  • Leukemia L1210

    an experimental lymphocytic leukemia of mice.
  • Leukemia L5178

    an experimental lymphocytic leukemia of mice.
  • Leukemia P388

    an experimental lymphocytic leukemia originally induced in dba/2 mice by painting with methylcholanthrene.
  • Leukemia Virus, Bovine

    the type species of deltaretrovirus that causes a form of bovine lymphosarcoma (enzootic bovine leukosis) or persistent lymphocytosis.
  • Leukemia Virus, Feline

    a species of gammaretrovirus causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. several cellular oncogenes confer on felv the ability to induce sarcomas (see also sarcoma viruses, feline).
  • Leukemia Virus, Gibbon Ape

    a species of gammaretrovirus causing leukemia in the gibbon ape. natural transmission is by contact.
  • Leukemia Virus, Murine

    species of gammaretrovirus, containing many well-defined strains, producing leukemia in mice. disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
  • Leukemia, Basophilic, Acute

    a rare acute myeloid leukemia in which the primary differentiation is to basophils. it is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. mature basophils are usually sparse.
  • Leukemia, B-Cell

    a malignant disease of the b-lymphocytes in the bone marrow and/or blood.
  • Leukemia, Biphenotypic, Acute

    an acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from multipotent stem cells.
  • Leukemia, Eosinophilic, Acute

    a rare acute myeloid leukemia characterized by abnormal eosinophils in the bone marrow.
  • Leukemia, Erythroblastic, Acute

    a myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
  • Leukemia, Experimental

    leukemia induced experimentally in animals by exposure to leukemogenic agents, such as viruses; radiation; or by transplantation of leukemic tissues.
  • Leukemia, Feline

    a neoplastic disease of cats frequently associated with feline leukemia virus infection.
  • Leukemia, Hairy Cell

    a neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
  • Leukemia, Large Granular Lymphocytic

    a spectrum of disorders characterized by clonal expansions of the peripheral blood lymphocyte populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. subtypes develop from either cd3-negative natural killer cells or cd3-positive t-cells. the clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
  • Leukemia, Lymphocytic, Chronic, B-Cell

    a chronic leukemia characterized by abnormal b-lymphocytes and often generalized lymphadenopathy. in patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (cll); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. these terms represent spectrums of the same disease.
  • Leukemia, Lymphoid

    leukemia associated with hyperplasia of the lymphoid tissues and increased numbers of circulating malignant lymphocytes and lymphoblasts.
  • Leukemia, Mast-Cell

    a form of systemic mastocytosis (mastocytosis, systemic) characterized by the presence of large numbers of tissue mast cells in the peripheral blood without skin lesions. it is a high-grade leukemia disease with bone marrow smear of >20% mast cells, multi-organ failure and a short survival.
  • Leukemia, Megakaryoblastic, Acute

    an acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. myelofibrosis or increased bone marrow reticulin is common.
  • Leukemia, Monocytic, Acute

    an acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and monocytes.
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive

    clonal hematopoetic disorder caused by an acquired genetic defect in pluripotent stem cells. it starts in myeloid cells of the bone marrow, invades the blood and then other organs. the condition progresses from a stable, more indolent, chronic phase (leukemia, myeloid, chronic phase) lasting up to 7 years, to an advanced phase composed of an accelerated phase (leukemia, myeloid, accelerated phase) and blast crisis.
  • Leukemia, Myeloid

    form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (myeloid progenitor cells) in the bone marrow and other sites.
  • Leukemia, Myeloid, Accelerated Phase

    the phase of chronic myeloid leukemia following the chronic phase (leukemia, myeloid, chronic-phase), where there are increased systemic symptoms, worsening cytopenias, and refractory leukocytosis.
  • Leukemia, Myeloid, Acute

    clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. myeloid leukemias develop from changes in cells that normally produce neutrophils; basophils; eosinophils; and monocytes.
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

    a myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to chronic myeloid leukemia, but cytogenetically lacking a philadelphia chromosome or bcr/abl fusion gene (genes, abl).
  • Leukemia, Myeloid, Chronic-Phase

    the initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. patients range from asymptomatic to those exhibiting anemia; splenomegaly; and increased cell turnover. there are 5% or fewer blast cells in the blood and bone marrow in this phase.
  • Leukemia, Myelomonocytic, Acute

    a pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. at least 20% of non-erythroid cells are of monocytic origin.
  • Leukemia, Myelomonocytic, Chronic

    a myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.
  • Leukemia, Myelomonocytic, Juvenile

    a leukemia affecting young children characterized by splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. traditionally classed as a myeloproliferative disease, it is now considered a mixed myeloproliferative-mylelodysplastic disorder.
  • Leukemia, Neutrophilic, Chronic

    a rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. no monocytosis, eosinophilia, or basophilia is present, nor is there a philadelphia chromosome or bcr-abl fusion gene (genes, abl).
  • Leukemia, Plasma Cell

    a rare, aggressive variant of multiple myeloma characterized by the circulation of excessive plasma cells in the peripheral blood. it can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.
  • Leukemia, Prolymphocytic

    a chronic leukemia characterized by a large number of circulating prolymphocytes. it can arise spontaneously or as a consequence of transformation of chronic lymphocytic leukemia.
  • Leukemia, Prolymphocytic, B-Cell

    a neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. it is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.
  • Leukemia, Prolymphocytic, T-Cell

    a lymphoid leukemia characterized by a profound lymphocytosis with or without lymphadenopathy, hepatosplenomegaly, frequently rapid progression, and short survival. it was formerly called t-cell chronic lymphocytic leukemia.
  • Leukemia, Promyelocytic, Acute

    an acute myeloid leukemia in which abnormal promyelocytes predominate. it is frequently associated with disseminated intravascular coagulation.
  • Leukemia, Radiation-Induced

    leukemia produced by exposure to ionizing radiation or non-ionizing radiation.
  • Leukemia, T-Cell

    a malignant disease of the t-lymphocytes in the bone marrow, thymus, and/or blood.
  • Leukemia-Lymphoma, Adult T-Cell

    aggressive t-cell malignancy with adult onset, caused by human t-lymphotropic virus 1. it is endemic in japan, the caribbean basin, southeastern united states, hawaii, and parts of central and south america and sub-saharan africa.
  • Moloney murine leukemia virus

    a strain of murine leukemia virus (leukemia virus, murine) arising during the propagation of s37 mouse sarcoma, and causing lymphoid leukemia in mice. it also infects rats and newborn hamsters. it is apparently transmitted to embryos in utero and to newborns through mother's milk.
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

    a leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. frequent sites involve lymph nodes, skin, and bones. it most commonly presents as leukemia.
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

    a neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. it is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

    a leukemia/lymphoma found predominately in children and young adults and characterized lymphadenopathy and thymus gland involvement. it most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.
  • Radiation Leukemia Virus

    a strain of murine leukemia virus (leukemia virus, murine) isolated from radiation-induced lymphomas in c57bl mice. it is leukemogenic, thymotrophic, can be transmitted vertically, and replicates only in vivo.
  • Rauscher Virus

    a strain of murine leukemia virus associated with mouse tumors similar to those caused by the friend murine leukemia virus. it is a replication-competent murine leukemia virus. it can act as a helper virus when complexing with a defective transforming component, rauscher spleen focus-forming virus.
  • Receptors, OSM-LIF

    cell surface receptors formed from the dimerization of lif receptor alpha subunit with cytokine receptor gp130. although originally described as receptors for leukemia inhibitory factor these receptors also bind the closely-related protein oncostatin m and are referred to as both lif receptors and type i oncostatin m receptors.
  • Stathmin

    a ubiquitous phosphoprotein that serves as an intracellular substrate for a variety of signal transduction pathways. phosphorylation of stathmin occurs during cell cycle progression, and stathmin functions as a microtubule-destabilizing protein that promotes microtubule depolymerization during interphase and late mitosis. stathmin is expressed at very high levels in a variety of human cancers.
  • Tetraspanin 29

    a subtype of tetraspanin protein that plays a role in cell adhesion, cell motility, and tumor metastasis. it functions in platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.
  • Eosinophils

    granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
  • Interleukin-6

    a cytokine that stimulates the growth and differentiation of b-lymphocytes and is also a growth factor for hybridomas and plasmacytomas. it is produced by many different cells including t-lymphocytes; monocytes; and fibroblasts.
  • Gammaretrovirus

    a genus of retroviridae comprising endogenous sequences in mammals, related reticuloendotheliosis viruses, avian, and a reptilian virus. many species contain oncogenes and cause leukemias and sarcomas.
  • Basophils

    granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
  • B-Lymphocytes

    lymphoid cells concerned with humoral immunity. they are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
  • Multipotent Stem Cells

    specialized stem cells that are committed to give rise to cells that have a particular function; examples are myoblasts; myeloid progenitor cells; and skin stem cells. (stem cells: a primer [internet]. bethesda (md): national institutes of health (us); 2000 may [cited 2002 apr 5]. available from: http://www.nih.gov/news/stemcell/primer.htm)
  • Monocytes

    large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
  • Myeloid Progenitor Cells

    stem cells derived from hematopoietic stem cells. derived from these myeloid progenitor cells are the megakaryocytes; erythroid cells; myeloid cells; and some dendritic cells.
  • Splenomegaly

    enlargement of the spleen.
  • T-Lymphocytes

    lymphocytes responsible for cell-mediated immunity. two types have been identified - cytotoxic (t-lymphocytes, cytotoxic) and helper t-lymphocytes (t-lymphocytes, helper-inducer). they are formed when lymphocytes circulate through the thymus gland and differentiate to thymocytes. when exposed to an antigen, they divide rapidly and produce large numbers of new t cells sensitized to that antigen.
  • Lymph Nodes

    they are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Leukemia, unspecified with failed remission
  • Leukemia NOS

Convert C95.90 to ICD-9-CM

  • ICD-9-CM Code: 208.20 - Sbc leu un cl wo ah rmsn
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 208.80 - Ot leu un cl wo ach rmsn
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 208.90 - Leuk NOS w/o achv rmsn
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education


Leukemia

What is leukemia?

Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job:

  • White blood cells help your body fight infection
  • Red blood cells deliver oxygen from your lungs to your tissues and organs
  • Platelets help form clots to stop bleeding

When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.

What are the types of leukemia?

There are different types of leukemia. Which type of leukemia you have depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly.

The type of blood cell could be:

  • Lymphocytes, a type of white blood cell
  • Myeloid cells, immature cells that become white blood cells, red blood cells, or platelets

The different types can grow quickly or slowly:

  • Acute leukemia is fast growing. It usually gets worse quickly if it's not treated.
  • Chronic leukemia is slow growing. It usually gets worse over a longer period of time.

The main types of leukemia are:

  • Acute lymphocytic leukemia (ALL), which is the most common type of cancer in children. It can also affect adults.
  • Acute myeloid leukemia (AML), which is more common in older adults but can also affect children
  • Chronic lymphocytic leukemia (CLL), which is one of the most common types of leukemia in adults. It often occurs during or after middle age.
  • Chronic myeloid leukemia (CML), which usually occurs in adults during or after middle age

What causes leukemia?

Leukemia happens when there are changes in the genetic material (DNA) in bone marrow cells. The cause of these genetic changes is unknown.

Who is at risk for leukemia?

For the specific types, there are different factors which can raise your risk of getting that type. Overall, your risk of leukemia goes up as you age. It is most common over age 60.

What are the symptoms of leukemia?

Some of the symptoms of leukemia may include:

  • Feeling tired
  • Fever or night sweats
  • Easy bruising or bleeding
  • Weight loss or loss of appetite
  • Petechiae, which are tiny red dots under the skin. They are caused by bleeding.

Other leukemia symptoms can be different from type to type. Chromic leukemia may not cause symptoms at first.

How is leukemia diagnosed?

Your health care provider may use many tools to diagnose leukemia:

  • A physical exam
  • A medical history
  • Blood tests, such as a complete blood count (CBC)
  • Bone marrow tests. There are two main types - bone marrow aspiration and bone marrow biopsy. Both tests involve removing a sample of bone marrow and bone. The samples are sent to a lab for testing.
  • Genetic tests to look for gene and chromosome changes

Once the provider makes a diagnosis, there may be additional tests to see whether the cancer has spread. These include imaging tests and a lumbar puncture, which is a procedure to collect and test cerebrospinal fluid (CSF).

What are the treatments for leukemia?

The treatments for leukemia depend on which type you have, how severe the leukemia is, your age, your overall health, and other factors. Some possible treatments might include:

  • Chemotherapy
  • Radiation therapy
  • Chemotherapy with stem cell transplant
  • Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.