ICD-10 Code T45.3X6

Underdosing of enzymes

Version 2019 Replaced Code Non-Billable Code Underdosing

Not Valid for Submission

T45.3X6 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of underdosing of enzymes. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10: T45.3X6
Short Description:Underdosing of enzymes
Long Description:Underdosing of enzymes

Consider the following ICD-10 codes with a higher level of specificity:

  • T45.3X6A - Underdosing of enzymes, initial encounter
  • T45.3X6D - Underdosing of enzymes, subsequent encounter
  • T45.3X6S - Underdosing of enzymes, sequela

Replaced Code

This code was replaced in the 2020 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2019. This code was replaced for the FY 2020 (October 1, 2019 - September 30, 2020).

  • K59.03 - Drug induced constipation

Code Classification

  • Injury, poisoning and certain other consequences of external causes (S00–T98)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances (T36-T50)
      • Primarily systemic and hematological agents, NEC (T45)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (first year ICD-10-CM implemented into the HIPAA mandated code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Medical Professionals

Table of Drugs and Chemicals

The code T45.3X6 is included in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. Use as many codes as necessary to describe all reported drugs, medicinal or chemical substances.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
self-harm
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AlgluceraseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
AlidaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
BrinaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
BromelainsT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
CatalaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
ChymarT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Chymar
  »ophthalmic preparation
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
ChymopapainT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
ChymotrypsinT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Chymotrypsin
  »ophthalmic preparation
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
CocarboxylaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Deoxyribonuclease (pancreatic)T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
DiffusinT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
EnzodaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NECT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »depolymerizing
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »fibrolytic
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »gastric
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »intestinal
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »local action
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »proteolytic
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
Enzyme NEC
  »thrombolytic
T45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
HyaluronidaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
HyazymeT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
PenicillinaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
PronaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
SerrapeptaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
StreptodornaseT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
SutilainsT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6
TrypsinT45.3X1T45.3X2T45.3X3T45.3X4T45.3X5T45.3X6

Information for Patients


Medication Errors

Medicines treat infectious diseases, prevent problems from chronic diseases, and ease pain. But medicines can also cause harmful reactions if not used correctly. Errors can happen in the hospital, at the health care provider's office, at the pharmacy, or at home. You can help prevent errors by

  • Knowing your medicines. When you get a prescription, ask the name of the medicine and check to make sure that the pharmacy gave you the right medicine. Make sure that you understand how often you should take the medicine and how long you should take it.
  • Keeping a list of medicines.
    • Write down all of the medicines that you are taking, including the names of your medicines, how much you take, and when you take them. Make sure to include any over-the-counter medicines, vitamins, supplements, and herbs that you take.
    • List the medicines that you are allergic to or that have caused you problems in the past.
    • Take this list with you every time you see a health care provider.
  • Reading medicine labels and following the directions. Don't just rely on your memory - read the medication label every time. Be especially careful when giving medicines to children.
  • Asking questions. If you don't know the answers to these questions, ask your health care provider or pharmacist:
    • Why am I taking this medicine?
    • What are the common side effects?
    • What should I do if I have side effects?
    • When should I stop this medicine?
    • Can I take this medicine with the other medicines and supplements on my list?
    • Do I need to avoid certain foods or alcohol while taking this medicine?

Food and Drug Administration


[Learn More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.