ICD-10-CM Code O99.322

Drug use complicating pregnancy, second trimester

Version 2021 Billable Code Maternity Diagnoses Diagnoses For Females Only Second Trimester (14 to 27 Weeks)

Valid for Submission

O99.322 is a billable code used to specify a medical diagnosis of drug use complicating pregnancy, second trimester. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions.

The code O99.322 is applicable to female patients aged 12 through 55 years inclusive. It is clinically and virtually impossible to use this code on a non-female patient outside the stated age range.

ICD-10:O99.322
Short Description:Drug use complicating pregnancy, second trimester
Long Description:Drug use complicating pregnancy, second trimester

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Maternity diagnoses - The Medicare Code Editor detects inconsistencies in maternity cases by checking a patient's age and any diagnosis on the patient's record. The maternity code edits apply to patients age ange is 9–64 years inclusive (e.g., diabetes in pregnancy, antepartum pulmonary complication).
  • Diagnoses for females only - The Medicare Code Editor detects inconsistencies between a patient’s sex and any diagnosis on the patient’s record, these edits apply to FEMALES only .

Diagnostic Related Groups

The ICD-10 code O99.322 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.

  • 817 - OTHER ANTEPARTUM DIAGNOSES WITH O.R. PROCEDURES WITH MCC
  • 818 - OTHER ANTEPARTUM DIAGNOSES WITH O.R. PROCEDURES WITH CC
  • 819 - OTHER ANTEPARTUM DIAGNOSES WITH O.R. PROCEDURES WITHOUT CC/MCC

Convert O99.322 to ICD-9

  • 648.31 - Drug dependence-deliver (Approximate Flag)
  • 648.33 - Drug dependence-antepart (Approximate Flag)

Code Classification

  • Pregnancy, childbirth and the puerperium (O00–O99)
    • Other obstetric conditions, not elsewhere classified (O94-O9A)
      • Oth maternal diseases classd elsw but compl preg/chldbrth (O99)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Pregnancy and Substance Abuse

When you are pregnant, you are not just "eating for two." You also breathe and drink for two. If you smoke, use alcohol or take illegal drugs, so does your unborn baby.

To protect your baby, you should avoid

  • Tobacco. Smoking during pregnancy passes nicotine, carbon monoxide, and other harmful chemicals to your baby. This could cause many problems for your unborn baby's development. It raises the risk of your baby being born too small, too early, or with birth defects. Smoking can also affect babies after they are born. Your baby would be more likely to develop diseases such as asthma and obesity. There is also a higher risk of dying from sudden infant death syndrome (SIDS).
  • Drinking alcohol. There is no known amount of alcohol that is safe for a woman to drink during pregnancy. If you drink alcohol when you are pregnant, your child could be born with lifelong fetal alcohol syndrome disorders (FASD). Children with FASD can have a mix of physical, behavioral, and learning problems.
  • Illegal drugs. Using illegal drugs such as cocaine and methamphetamines may cause underweight babies, birth defects, or withdrawal symptoms after birth.
  • Misusing prescription drugs. If you are taking prescription medicines, carefully follow your health care provider's instructions. It can be dangerous to take more medicines than you are supposed to, use them to get high, or take someone else's medicines. For example, misusing opioids can cause birth defects, withdrawal in the baby, or even loss of the baby.

If you are pregnant and you are doing any of these things, get help. Your healthcare provider can recommend programs to help you quit. You and your baby's health depend on it.

Dept. of Health and Human Services Office on Women's Health

  • Alcohol and pregnancy (Medical Encyclopedia)
  • Neonatal abstinence syndrome (Medical Encyclopedia)
  • Smoking and Pregnancy (Centers for Disease Control and Prevention)

[Learn More]