2024 ICD-10-CM Diagnosis Code T38.2X5

Specific Coding Applicable to Adverse effect of antithyroid drugs

Non-specific codes like T38.2X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of antithyroid drugs:

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Adverse reaction to thiourea
• Agranulocytosis
• Agranulocytosis caused by antithyroid agent
• Antithyroid drug adverse reaction
• Carbimazole adverse reaction
• Endocrine system complication of procedure
• Hyperthyroidism secondary to potassium iodide
• Iodine-induced hyperthyroidism
• Pancytopenia caused by antithyroid drug
• Pancytopenia caused by medication
• Post iodine 131 treatment radiation thyroiditis
• Propylthiouracil adverse reaction
• Thiouracil antithyroid agent adverse reaction
• Thyroid disease monitoring status
• Thyroid drug side effects

Clinical Information

• Carbimazole

  an imidazole antithyroid agent. carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.

• Diiodotyrosine

  a product from the iodination of monoiodotyrosine. in the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form t4 or t3 thyroid hormones (thyroxine and triiodothyronine).

• Receptors, Thyroid Hormone

  specific high affinity binding proteins for thyroid hormones in target cells. they are usually found in the nucleus and regulate dna transcription. these receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. thyroid hormone receptors are encoded by two genes (genes, erba): erba-alpha and erba-beta for alpha and beta thyroid hormone receptors, respectively.

• Methimazole

  a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. this is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

• Methylthiouracil

  a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. it is used in the treatment of hyperthyroidism.

• Propylthiouracil

  a thiourea antithyroid agent. propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. it is used in the treatment of hyperthyroidism. (from martindale, the extra pharmacopeoia, 30th ed, p534)

• Thiourea

  a photographic fixative used also in the manufacture of resins. according to the fourth annual report on carcinogens (ntp 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (merck index, 9th ed). many of its derivatives are antithyroid agents and/or free radical scavengers.

• Agranulocytosis

  a decrease in the number of granulocytes; (basophils; eosinophils; and neutrophils).

• Feline Panleukopenia

  a highly contagious dna virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. it is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. it is caused by feline panleukopenia virus or the closely related mink enteritis virus or canine parvovirus.

• Agranulocytosis

  a marked decrease in the number of mature granulocytes (most often neutrophils) in the peripheral blood.

• Chemotherapy Related Agranulocytosis|Chemotherapy-Related Agranulocytosis

  agranulocytosis that occurs with chemotherapy.

• Congenital Neutropenia|congenital neutropenia|genetic infantile agranulocytosis|infantile genetic agranulocytosis

  a rare congenital disorder characterized by mild or severe reduction of neutrophils in the peripheral blood and recurrent infantile infections.

• Cyclic Neutropenia|CH|CN|Cyclic Agranulocytosis|Cyclic Hematopoiesis|Cyclic Hematopoiesis|Dysplasia, Myelocytic Periodic|Periodic Neutropenia|cyclic neutropenia|periodic neutropenia

  a hematologic disorder caused by a mutation in the elane (ela2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (T38). Use the following options for the aplicable episode of care:

• A - initial encounter
• D - subsequent encounter
• S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Filter table of drugs and chemicals:

Substance	Poisoning Accidental (unintentional)	Poisoning Accidental (self-harm)	Poisoning Assault	Poisoning Undetermined	Adverse effect	Underdosing
Antithyroid drug NEC	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Benzylthiouracil	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Carbimazole	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Diiodotyrosine	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Iothiouracil	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Methiacil	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Methimazole	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Methylthiouracil	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Propylthiouracil	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Tapazole	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Thiamazole	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Thiocarbamide	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Thiouracil (benzyl) (methyl) (propyl)	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6
Thiourea	T38.2X1	T38.2X2	T38.2X3	T38.2X4	T38.2X5	T38.2X6

Patient Education

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

• Two drugs, such as aspirin and blood thinners
• Drugs and food, such as statins and grapefruit
• Drugs and supplements, such as gingko and blood thinners
• Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.

[Learn More in MedlinePlus]

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.