Symptoms and signs specifically associated with systemic inflammation and infection (R65)
Clinical Information
Endotoxemia - A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Endotoxins - Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Systemic Inflammatory Response Syndrome - A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)
General symptoms and signs (R50-R69)
R65 Symptoms and signs specifically associated with systemic inflammation and infection
R65.1 Systemic inflammatory response syndrome (SIRS) of non-infectious origin
- R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
- R65.11 Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
R65.2 Severe sepsis
- R65.20 Severe sepsis without septic shock
- R65.21 Severe sepsis with septic shock
Symptoms and signs specifically associated with systemic inflammation and infection (R65)