Other disorders involving the immune mechanism, not elsewhere classified (D89)
Clinical Information
Autoimmune Lymphoproliferative Syndrome - Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.
Cryoglobulinemia - A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
Cryoglobulins - Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
Cytokine Release Syndrome - A severe immune reaction characterized by excessive release of CYTOKINES. Symptoms include DYSPNEA; FEVER; HEADACHE; HYPOTENSION; NAUSEA; RASH; TACHYCARDIA; HYPOXIA; HYPERFERRITINEMIA, and MULTIPLE ORGAN FAILURE. It is associated with viral infections, SEPSIS; AUTOIMMUNE DISEASES and a variety of factors used in IMMUNOTHERAPY.
Hypergammaglobulinemia - An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.
Keratoconjunctivitis Sicca - Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.
Mast Cell Activation Syndrome - A clinically and genetically heterogeneous group of mast cell disorders in which there is aberrant release of mast cell mediators with little to no accompanying proliferation of MAST CELLS.
Mast Cells - Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Instructional Notations
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- transplant failure and rejection T86
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
Certain disorders involving the immune mechanism (D80-D89)
D89 Other disorders involving the immune mechanism, not elsewhere classified
- D89.0 Polyclonal hypergammaglobulinemia
- D89.1 Cryoglobulinemia
- D89.2 Hypergammaglobulinemia, unspecified
- D89.3 Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
- D89.40 Mast cell activation, unspecified
- D89.41 Monoclonal mast cell activation syndrome
- D89.42 Idiopathic mast cell activation syndrome
- D89.43 Secondary mast cell activation
- D89.44 Hereditary alpha tryptasemia
- D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
- D89.810 Acute graft-versus-host disease
- D89.811 Chronic graft-versus-host disease
- D89.812 Acute on chronic graft-versus-host disease
- D89.813 Graft-versus-host disease, unspecified
- D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.83 Cytokine release syndrome
- D89.831 Cytokine release syndrome, grade 1
- D89.832 Cytokine release syndrome, grade 2
- D89.833 Cytokine release syndrome, grade 3
- D89.834 Cytokine release syndrome, grade 4
- D89.835 Cytokine release syndrome, grade 5
- D89.839 Cytokine release syndrome, grade unspecified
- D89.84 IgG4-related disease NEW CODE
- D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.9 Disorder involving the immune mechanism, unspecified
Other disorders involving the immune mechanism, not elsewhere classified (D89)