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  6. 2024 ICD-10-CM Code E85
Version 2024
Non-Billable Code

2024 ICD-10-CM Diagnosis Code E85

Amyloidosis

ICD-10-CM Code:
E85
ICD-10 Code for:
Amyloidosis
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Endocrine, nutritional and metabolic diseases
    (E00–E89)

E85 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of amyloidosis. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Amyloidosis

Non-specific codes like E85 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for amyloidosis:

  • Use E85.0 for Non-neuropathic heredofamilial amyloidosis - BILLABLE CODE

  • Use E85.1 for Neuropathic heredofamilial amyloidosis - BILLABLE CODE

  • Use E85.2 for Heredofamilial amyloidosis, unspecified - BILLABLE CODE

  • Use E85.3 for Secondary systemic amyloidosis - BILLABLE CODE

  • Use E85.4 for Organ-limited amyloidosis - BILLABLE CODE

  • E85.8 for Other amyloidosis - NON-BILLABLE CODE

  • Use E85.81 for Light chain (AL) amyloidosis - BILLABLE CODE

  • Use E85.82 for Wild-type transthyretin-related (ATTR) amyloidosis - BILLABLE CODE

  • Use E85.89 for Other amyloidosis - BILLABLE CODE

  • Use E85.9 for Amyloidosis, unspecified - BILLABLE CODE

Clinical Information

  • Amyloid Neuropathies, Familial

    inherited disorders of the peripheral nervous system associated with the deposition of amyloid in nerve tissue. the different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (prealbumin); apolipoprotein a-i; and gelsolin.

  • Amyloidosis

    a group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of amyloid. as the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. various signs and symptoms depend on the location and size of the deposits.

  • Amyloidosis, Familial

    diseases in which there is a familial pattern of amyloidosis.

  • Cerebral Amyloid Angiopathy, Familial

    a familial disorder marked by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges.

  • Immunoglobulin Light-chain Amyloidosis

    a nonproliferative disorder of the plasma cell characterized by excessive production and misfolding of immunoglobulin light chains that form insoluble amyloid fibrils (see amyloid deposits) in various tissues. clinical features include liver failure; multiple myeloma; nephrotic syndrome; restrictive cardiomyopathy, and neuropathies.

  • Amyloid

    a fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. this fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. deposits of amyloid in the form of amyloid plaques are associated with a variety of degenerative diseases. the amyloid structure has also been found in a number of functional proteins that are unrelated to disease.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • Alzheimer's disease G30.0

Patient Education


Amyloidosis

Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

There are three main types of amyloidosis:

  • Primary - with no known cause
  • Secondary - caused by another disease, including some types of cancer
  • Familial - passed down through genes

Symptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.