ICD-10 Diagnosis Code E74.4

Disorders of pyruvate metabolism and gluconeogenesis

Diagnosis Code E74.4

ICD-10: E74.4
Short Description: Disorders of pyruvate metabolism and gluconeogenesis
Long Description: Disorders of pyruvate metabolism and gluconeogenesis
This is the 2017 version of the ICD-10-CM diagnosis code E74.4

Code Classification
  • Endocrine, nutritional and metabolic diseases
    • Metabolic disorders (E70-E88)
      • Other disorders of carbohydrate metabolism (E74)

Information for Medical Professionals

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  • Deficiency of acylphosphatase
  • Deficiency of dihydrolipoamide acetyltransferase
  • Deficiency of D-lactate dehydrogenase
  • Deficiency of glucose-1-phosphate phosphodismutase
  • Deficiency of lactate racemase
  • Deficiency of L-lactate dehydrogenase
  • Deficiency of L-lactate dehydrogenase
  • Deficiency of pyruvate decarboxylase
  • Disorder of pyruvate metabolism and mitochondrial respiratory chain
  • Disorders of pyruvate metabolism and gluconeogenesis
  • Inborn error of pyruvate metabolism
  • Lactate dehydrogenase deficiency
  • Lactic acidosis
  • Muscle L-lactate dehydrogenase deficiency
  • Phosphoenolpyruvate carboxykinase deficiency
  • Pyruvate carboxylase deficiency
  • Pyruvate dehydrogenase complex deficiency

Index of Diseases and Injuries
References found for the code E74.4 in the Index of Diseases and Injuries:

Information for Patients

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.

A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.

You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.

  • Acidosis
  • Alkalosis
  • Lactic acid test
  • Metabolic acidosis
  • Metabolic neuropathies
  • Pseudohypoparathyroidism

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Pyruvate carboxylase deficiency Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid and other potentially toxic compounds to accumulate in the blood. High levels of these substances can damage the body's organs and tissues, particularly in the nervous system.Researchers have identified at least three types of pyruvate carboxylase deficiency, which are distinguished by the severity of their signs and symptoms. Type A, which has been identified mostly in people from North America, has moderately severe symptoms that begin in infancy. Characteristic features include developmental delay and a buildup of lactic acid in the blood (lactic acidosis). Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, and difficulty breathing. In some cases, episodes of lactic acidosis are triggered by an illness or periods without food (fasting). Children with pyruvate carboxylase deficiency type A typically survive only into early childhood.Pyruvate carboxylase deficiency type B has life-threatening signs and symptoms that become apparent shortly after birth. This form of the condition has been reported mostly in Europe, particularly France. Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. They experience neurological problems including weak muscle tone (hypotonia), abnormal movements, seizures, and coma. Infants with this form of the condition usually survive for less than 3 months after birth.A milder form of pyruvate carboxylase deficiency, sometimes called type C, has also been described. This type is characterized by slightly increased levels of lactic acid in the blood and minimal signs and symptoms affecting the nervous system.
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