ICD-10 Diagnosis Code D68.51

Activated protein C resistance

Diagnosis Code D68.51

ICD-10: D68.51
Short Description: Activated protein C resistance
Long Description: Activated protein C resistance
This is the 2017 version of the ICD-10-CM diagnosis code D68.51

Code Classification
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)
      • Other coagulation defects (D68)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code D68.51 is grouped in the following Diagnostic Related Group(s) (MS-DRG v33.0)


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The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Factor V Leiden mutation
  • Heterozygous Factor V Leiden mutation
  • Homozygous Factor V Leiden mutation
  • Resistance to activated protein C caused by Factor V Leiden

Index of Diseases and Injuries
References found for the code D68.51 in the Index of Diseases and Injuries:

Information for Patients

Bleeding Disorders

Also called: Clotting disorders

Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.

Bleeding disorders can be the result of other diseases, such as severe liver disease. They can also be inherited. Hemophilia is an inherited bleeding disorder. Bleeding disorders can also be a side effect of medicines.

  • Bleeding disorders
  • Bleeding time
  • Disseminated intravascular coagulation (DIC)
  • Partial thromboplastin time (PTT)
  • Prothrombin time (PT)

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Factor V Leiden thrombophilia Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels.People with factor V Leiden thrombophilia have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT). DVTs occur most often in the legs, although they can also occur in other parts of the body, including the brain, eyes, liver, and kidneys. Factor V Leiden thrombophilia also increases the risk that clots will break away from their original site and travel through the bloodstream. These clots can lodge in the lungs, where they are known as pulmonary emboli. Although factor V Leiden thrombophilia increases the risk of blood clots, only about 10 percent of individuals with the factor V Leiden mutation ever develop abnormal clots.The factor V Leiden mutation is associated with a slightly increased risk of pregnancy loss (miscarriage). Women with this mutation are two to three times more likely to have multiple (recurrent) miscarriages or a pregnancy loss during the second or third trimester. Some research suggests that the factor V Leiden mutation may also increase the risk of other complications during pregnancy, including pregnancy-induced high blood pressure (preeclampsia), slow fetal growth, and early separation of the placenta from the uterine wall (placental abruption). However, the association between the factor V Leiden mutation and these complications has not been confirmed. Most women with factor V Leiden thrombophilia have normal pregnancies.
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