2024 ICD-10-CM Diagnosis Code D58.2

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Acquired hemoglobinopathy
• Acquired pseudoxanthoma elasticum
• Central cyanosis
• Hemoglobin C disease
• Hemoglobin C trait
• Hemoglobin D disease
• Hemoglobin D trait
• Hemoglobin E disease
• Hemoglobin E trait
• Hemoglobin O-Arab trait
• Hemoglobin Zurich disease
• Hemoglobinopathy
• Hemoglobinopathy Toms River
• Hemoglobinopathy with cyanosis
• Hemoglobinopathy with erythrocytosis
• Hereditary hemoglobinopathy
• Hereditary hemoglobinopathy due to globin chain mutation
• Heterozygous hemoglobinopathy
• High affinity hemoglobin
• Homozygous hemoglobinopathy
• Low affinity hemoglobin
• Mixed hemoglobin disorder
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis due to hemoglobinopathy
• Osteonecrosis of ankle due to hemoglobinopathy
• Osteonecrosis of bone of forearm due to hemoglobinopathy
• Osteonecrosis of femur due to hemoglobinopathy
• Osteonecrosis of foot due to hemoglobinopathy
• Osteonecrosis of hand due to hemoglobinopathy
• Osteonecrosis of humerus due to hemoglobinopathy
• Osteonecrosis of lower leg due to hemoglobinopathy
• Osteonecrosis of multiple sites due to hemoglobinopathy
• Osteonecrosis of pelvic region due to hemoglobinopathy
• Osteonecrosis of shoulder region due to hemoglobinopathy
• Pseudoxanthoma elasticum
• Pseudoxanthoma elasticum due to hemoglobinopathy
• Unstable hemoglobin disease

Clinical Information

• Hemoglobinopathies

  a group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

• Pseudoxanthoma Elasticum

  an inherited disorder of connective tissue with extensive degeneration and calcification of elastic tissue primarily in the skin, eye, and vasculature. at least two forms exist, autosomal recessive and autosomal dominant. this disorder is caused by mutations of one of the atp-binding cassette transporters. patients are predisposed to myocardial infarction and gastrointestinal hemorrhage.

• Hemoglobin C Disease

  a disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. there may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

• Hemoglobin E Disease

  a condition characterized by the presence of a variant of normal hemoglobin (hemoglobin e), which is caused by mutation(s) in the gene encoding the beta subunit of the hemoglobin molecule.

• Sickle Cell-Hemoglobin E Disease|Hemoglobin SE Disease

  a variant of sickle cell disease due to heterozygosity for hemoglobin s and hemoglobin e mutations. patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin ss disease.

• ABCC6 wt Allele|ABC34|ARA|ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 wt Allele|ATP-Binding Cassette, Subfamily C, Member 6 Gene|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|Pseudoxanthoma Elasticum Gene|URG7

  human abcc6 wild-type allele is located in the vicinity of 16p13.1 and is approximately 75 kb in length. this allele, which encodes multidrug resistance-associated protein 6, plays a role in the active transport of drugs across the plasma membrane. mutation of the gene is associated with pseudoxanthoma elasticum and generalized arterial calcification of infancy type 2.

• Pseudoxanthoma Elasticum

  a rare, progressive, autosomal recessive inherited disorder caused by mutations in the abcc6 gene. it is characterized by calcification and fragmentation of the elastic fibers of the skin, retina, and cardiovascular system. signs and symptoms include skin plaques and bumps, thickened skin, retinal hemorrhage and obstruction of the blood vessels.

• Spastic Paraplegia 56|Autosomal Recessive Spastic Paraplegia-56 with or without Pseudoxanthoma Elasticum|SPG56

  an autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the cyp2u1 gene, encoding cytochrome p450 2u1.

• Hemoglobin C Disease

  an autosomal recessive hemoglobinopathy with a mild clinical course. most patients are asymptomatic. when symptoms appear, they include mild hemolytic anemia and occasionally jaundice.

• Sickle Cell-Hemoglobin C Disease|HbSC|Hemoglobin SC Disease|Hemoglobin SC Disease

  a hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin c disease. patients present with the symptoms of sickle cell disease but the latter are less frequent and severe compared to sickle cell disease.

• Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease|Vaso-Occlusive Crisis in Hemoglobin SC Disease|Vaso-Occlusive Crisis of Hemoglobin SC Disease|Vaso-Occlusive Crisis of Sickle Cell-Hemoglobin C Disease

  sickle cell-hemoglobin c disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.

D58.2 is grouped with Diagnostic Related Groups - MS-DRG Mapping

Diagnostic Related Groups (DRGs) are a classification system used to group together diagnosis codes for the purpose of reimbursement and healthcare management. DRGs are used to standardize the way hospitals and other providers are paid for inpatient services. In this system patients are grouped together based on their principal diagnosis in areas referred to as Major Diagnostic Categories (MDC). Once a patient is assigned a particular diagnostic category, providers receive a predetermined payment rate for the services rendered. This reimbursement rate is often fixed and is meant to cover the cost of care for that patient. Reimbursement is also affected by the relative weight of a diagnostic related group based on the severity of a patient's illness and the associated cost of care during hospitalization.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V41.0 applicable from 10/01/2023 through 09/30/2024.

MS-DRG	MS-DRG Title	MCD	Relative Weight
811	RED BLOOD CELL DISORDERS WITH MCC	16	1.4036
812	RED BLOOD CELL DISORDERS WITHOUT MCC	16	0.9007

The relative weight of a diagnostic related group determines the reimbursement rate based on the severity of a patient's illness and the associated cost of care during hospitalization.

Convert D58.2 to ICD-9-CM

• ICD-9-CM Code: 282.7 - Hemoglobinopathies NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.

Conditions that may lead to anemia include:

• Heavy periods
• Pregnancy
• Ulcers
• Colon polyps or colon cancer
• Inherited disorders
• A diet that does not have enough iron, folic acid or vitamin B12
• Blood disorders such as sickle cell anemia and thalassemia, or cancer
• Aplastic anemia, a condition that can be inherited or acquired
• G6PD deficiency, a metabolic disorder

Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.

Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.

NIH: National Heart, Lung, and Blood Institute

[Learn More in MedlinePlus]

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.