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  6. 2024 ICD-10-CM Code D46
Version 2024
Non-Billable Code

2024 ICD-10-CM Diagnosis Code D46

Myelodysplastic syndromes

ICD-10-CM Code:
D46
ICD-10 Code for:
Myelodysplastic syndromes
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Neoplasms
    (C00–D49)
    • Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
      (D37-D48)
      • Myelodysplastic syndromes
        (D46)

D46 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of myelodysplastic syndromes. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Myelodysplastic syndromes

Non-specific codes like D46 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for myelodysplastic syndromes:

  • Use D46.0 for Refractory anemia without ring sideroblasts, so stated - BILLABLE CODE

  • Use D46.1 for Refractory anemia with ring sideroblasts - BILLABLE CODE

  • D46.2 for Refractory anemia with excess of blasts [RAEB] - NON-BILLABLE CODE

  • Use D46.20 for Refractory anemia with excess of blasts, unspecified - BILLABLE CODE

  • Use D46.21 for Refractory anemia with excess of blasts 1 - BILLABLE CODE

  • Use D46.22 for Refractory anemia with excess of blasts 2 - BILLABLE CODE

  • Use D46.4 for Refractory anemia, unspecified - BILLABLE CODE

  • Use D46.9 for Myelodysplastic syndrome, unspecified - BILLABLE CODE

  • Use D46.A for Refractory cytopenia with multilineage dysplasia - BILLABLE CODE

  • Use D46.B for Refractory cytopenia with multilineage dysplasia and ring sideroblasts - BILLABLE CODE

  • Use D46.C for Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality - BILLABLE CODE

  • Use D46.Z for Other myelodysplastic syndromes - BILLABLE CODE

Clinical Information

  • Myelodysplastic Syndromes

    clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. they predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into acute myeloid leukemia.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • code for adverse effect, if applicable, to identify drug T36 T50

Type 2 Excludes

Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • drug-induced aplastic anemia D61.1

Patient Education


Myelodysplastic Syndromes

Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. Many of them die in the bone marrow. This means that you do not have enough healthy cells, which can lead to infection, anemia, or easy bleeding.

Myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include:

  • Shortness of breath
  • Weakness or feeling tired
  • Skin that is paler than usual
  • Easy bruising or bleeding
  • Pinpoint spots under the skin caused by bleeding
  • Fever or frequent infections

Myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Myelodysplastic Syndromes Treatment (PDQ®)

Learn about the different types of myelodysplastic syndromes and their risk factors, signs and symptoms, tests to diagnose, factors affecting prognosis, and treatment.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.