2024 ICD-10-CM Diagnosis Code D21.9

Benign neoplasm of connective and other soft tissue, unspecified

ICD-10-CM Code:
D21.9
ICD-10 Code for:
Benign neoplasm of connective and other soft tissue, unsp
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Neoplasms
    (C00–D49)
    • Benign neoplasms, except benign neuroendocrine tumors
      (D10-D36)
      • Other benign neoplasms of connective and other soft tissue
        (D21)

D21.9 is a billable diagnosis code used to specify a medical diagnosis of benign neoplasm of connective and other soft tissue, unspecified. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic adipose tissue [See Also: Neoplasm, connective tissue] ; Neoplasm, neoplastic aponeurosis ; Neoplasm, neoplastic connective tissue NEC ; Neoplasm, neoplastic connective tissue NEC extremity ; Neoplasm, neoplastic connective tissue NEC limb NEC ; Neoplasm, neoplastic lymph, lymphatic channel NEC ; Neoplasm, neoplastic lymph, lymphatic channel NEC vessel [See Also: Neoplasm, connective tissue] ; etc

Unspecified diagnosis codes like D21.9 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adult rhabdomyoma
  • Angiomyoma of skin
  • Benign connective tissue neoplasm
  • Benign fibrohistiocytic neoplasm of soft tissue of limb
  • Benign neoplasm of blood vessel
  • Benign neoplasm of lymph vessels
  • Benign neoplasm of muscle
  • Benign neoplasm of nail apparatus
  • Benign neoplasm of nail apparatus
  • Benign neoplasm of nail apparatus
  • Benign neoplasm of soft tissue
  • Calcifying aponeurotic fibroma
  • Cutaneous leiomyoma
  • Cutaneous leiomyoma
  • Cutaneous leiomyoma
  • Familial multiple leiomyoma cutis
  • Fibroma
  • Fibroma of tendon sheath
  • Fibrous dysplasia of bone with intramuscular myxoma
  • Fibrous hamartoma of infancy
  • Fibrous histiocytoma of tendon sheath
  • Giant cell storiform collagenoma
  • Granular cell tumor
  • Granular cell tumor of skin
  • Hamartoma of muscle
  • Intravascular papillary endothelial hyperplasia
  • Juvenile aponeurotic fibroma
  • Kimura's disease
  • Leiomyoma
  • Multiple piloleiomyoma
  • Myopericytoma
  • Myxoma
  • Ossifying fibromyxoid tumor
  • Parachordoma
  • Parasitic fibroid
  • Periungual fibroma
  • Periungual fibroma
  • Periungual fibroma in tuberous sclerosis
  • Pilar leiomyoma
  • Rhabdomyoma
  • Soft tissue chondroma
  • Storiform collagenoma
  • Subungual fibroma
  • Vascular hamartomas

Clinical Classification

Clinical Information

  • Aponeurosis

    the flattened and/or expanded “tendon-like” dense fibrous connective tissue that connects skeletal muscles to each other or to bone.
  • Myopericytoma

    rare myofibroma-like perivascular soft tissue tumor, usually benign, characterized by concentric perivascular proliferation.
  • Angiomyoma

    a benign tumor consisting of vascular and smooth muscle elements.
  • Leiomyoma

    a benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. they rarely occur outside of the uterus and the gastrointestinal tract but can occur in the skin and subcutaneous tissue, probably arising from the smooth muscle of small blood vessels in these tissues.
  • Leiomyoma, Epithelioid

    a relatively rare smooth muscle tumor found most frequently in the wall of the gastrointestinal tract, especially in the stomach. it is similar to other smooth muscle tumors but may become very large and hemorrhage and exhibit small cystic areas. simple excision is almost always curative. (from dorland, 27th ed; devita jr et al., cancer: principles & practice of oncology, 3d ed, p1354)
  • Leiomyomatosis

    the state of having multiple leiomyomas throughout the body. (stedman, 25th ed)
  • Rhabdomyoma

    a benign tumor derived from striated muscle. it is extremely rare, generally occurring in the tongue, neck muscles, larynx, uvula, nasal cavity, axilla, vulva, and heart. these tumors are treated by simple excision. (dorland, 27th ed; devita jr et al., cancer: principles & practice of oncology, 3d ed, p1354)
  • Granular Cell Tumor

    unusual tumor affecting any site of the body, but most often encountered in the head and neck. considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. it affects women more often than men. when it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.
  • Carney Complex

    autosomal dominant syndrome characterized by cardiac and cutaneous myxomas; lentiginosis (spotty pigmentation of the skin), and endocrinopathy and its associated endocrine tumors. the cardiac myxomas may lead to sudden cardiac death and other complications in carney complex patients. the gene coding for the prkar1a protein is one of the causative genetic loci (type 1). a second locus is at chromosome 2p16 (type 2).
  • Myxoma

    a benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. it occurs frequently intramuscularly where it may be mistaken for a sarcoma. it appears also in the jaws and the skin. (from stedman, 25th ed)
  • Myxoma virus

    the type species of leporipoxvirus causing infectious myxomatosis, a severe generalized disease, in rabbits. tumors are not always present.
  • Myxomatosis, Infectious

    diseases caused by myxoma virus.
  • Neurothekeoma

    a benign myxoma of cutaneous nerve sheath origin. theke is from the greek theke, sheath. (from stedman, 25th ed)
  • Cementoma

    an odontogenic fibroma in which cells have developed into cementoblasts and which consists largely of cementum.
  • Dupuytren Contracture

    a fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. it arises most commonly in men between the ages of 30 and 50.
  • Fibroma

    a benign tumor of fibrous or fully developed connective tissue.
  • Fibroma Virus, Rabbit

    a species of leporipoxvirus causing subcutaneous localized swellings in rabbits, usually on the feet.
  • Fibroma, Desmoplastic

    an extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. it appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (devita jr et al., cancer: principles & practice of oncology, 3d ed, p1441)
  • Fibroma, Ossifying

    a benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.
  • Fibromatosis, Abdominal

    a relatively large mass of unusually firm scarlike connective tissue resulting from active participation of fibroblasts, occurring most frequently in the abdominal muscles of women who have borne children. the fibroblasts infiltrate surrounding muscle and fascia. (stedman, 25th ed)
  • Fibromatosis, Aggressive

    a childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. the adult form of abdominal fibromatosis is fibromatosis, abdominal. (stedman, 25th ed)
  • Fibromatosis, Gingival

    generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. the enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (dorland, 28th ed)
  • Fibromatosis, Plantar

    a fibromatosis of the plantar fascia characterized by thickening of the fibrous bands on the plantar aponeurosis in the sole of the foot and toes.
  • Hyalinosis, Systemic

    autosomal recessive disorder characterized by hyaline deposition in the skin, bone, gastrointestinal tract, muscles and glands; multiple subcutaneous skin nodules; gingival hypertrophy; and joint contractures. mutations in the capillary morphogenesis protein-2 are associated with the disorder.
  • Penile Induration

    a condition characterized by hardening of the penis due to the formation of fibrous plaques on the dorsolateral aspect of the penis, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). this may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.
  • Solitary Fibrous Tumor, Pleural

    a rare neoplasm, usually benign, derived from mesenchymal fibroblasts located in the submesothelial lining of the pleura. it spite of its various synonyms, it has no features of mesothelial cells and is not related to malignant mesothelioma or asbestos exposure.
  • Tumor Virus Infections

    infections produced by oncogenic viruses. the infections caused by dna viruses are less numerous but more diverse than those caused by the rna oncogenic viruses.
  • Leporipoxvirus

    a genus of the family poxviridae, subfamily chordopoxvirinae, consisting of ether-sensitive viruses of leporids and squirrels. they commonly cause tumors and are usually transmitted mechanically by arthropods. myxoma virus is the type species.
  • Chest Wall Parachordoma|Parachordoma of Chest Wall|Parachordoma of the Chest Wall

    a parachordoma arising from the chest wall.
  • Parachordoma

    a rare, usually benign myoepithelial tumor characterized by the presence of epithelioid, often vacuolated neoplastic cells. most patients present with painless swelling in the subcutaneous or subfascial soft tissues of the extremities.

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert D21.9 to ICD-9-CM

  • ICD-9-CM Code: 215.9 - Ben neo soft tissue NOS
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Table of Neoplasms

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
Primary
Malignant
Secondary
CaInSitu Benign Uncertain
Behavior
Unspecified
Behavior
»Neoplasm, neoplastic
  »adipose tissue [See Also: Neoplasm, connective tissue]
C49.4C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »aponeurosis
C49.9C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »connective tissue NEC
C49.9C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »connective tissue NEC
    »extremity
C49.9C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »connective tissue NEC
    »limb NEC
C49.9C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »lymph, lymphatic channel NEC
C49.9C79.89 D21.9D48.1D49.2
»Neoplasm, neoplastic
  »lymph, lymphatic channel NEC
    »vessel [See Also: Neoplasm, connective tissue]
C49.9C79.89 D21.9D48.1D49.2

Patient Education


Benign Tumors

Tumors are abnormal growths in your body. They can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Benign tumors grow only in one place. They cannot spread or invade other parts of your body. Even so, they can be dangerous if they press on vital organs, such as your brain.

Tumors are made up of extra cells. Normally, cells grow and divide to form new cells as your body needs them. When cells grow old, they die, and new cells take their place. Sometimes, this process goes wrong. New cells form when your body does not need them, and old cells do not die when they should. These extra cells can divide without stopping and may form tumor.

Treatment often involves surgery. Benign tumors usually don't grow back.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.