2024 ICD-10-CM Diagnosis Code T48.3X5

Adverse effect of antitussives

ICD-10-CM Code:
T48.3X5
ICD-10 Code for:
Adverse effect of antitussives
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system
        (T48)

T48.3X5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of antitussives. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Adverse effect of antitussives

Non-specific codes like T48.3X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of antitussives:

  • Use T48.3X5A for initial encounter - BILLABLE CODE

  • Use T48.3X5D for subsequent encounter - BILLABLE CODE

  • Use T48.3X5S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction to pipazethate
  • Cough suppressant adverse reaction
  • Dextromethorphan hydrobromide adverse reaction
  • Isoaminile adverse reaction
  • Noscapine adverse reaction
  • Pholcodine adverse reaction

Clinical Information

  • Dextromethorphan

    methyl analog of dextrorphan that shows high affinity binding to several regions of the brain, including the medullary cough center. this compound is an nmda receptor antagonist (receptors, n-methyl-d-aspartate) and acts as a non-competitive channel blocker. it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
  • Noscapine

    a naturally occurring opium alkaloid that is a centrally acting antitussive agent.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (T48). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Antitussive NECT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Antitussive NEC
  »codeine mixture
T48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Antitussive NEC
  »opiate
T48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
BenproperineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
BenzonatateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Bibenzonium bromideT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ButamirateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
CarbetapentaneT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ChlophedianolT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ClobutinolT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ClofedanolT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
CloperastineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ClophedianolT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
DextromethorphanT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Dibunate sodiumT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
DimemorfanT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
DimethoxanateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
DropropizineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
FedrilateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
FominobenT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Isoaminile (citrate)T48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
LevdropropizineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
MethorateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
NarcotineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
NectadonT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
NoscapineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
Oxeladin (citrate)T48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
OxolamineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PentoxyverineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PholcodineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PicoperineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PipazetateT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PiperidioneT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
PrenoxdiazineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
RomilarT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
TessalonT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ThebaconT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
TipepidineT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6
ZipeprolT48.3X1T48.3X2T48.3X3T48.3X4T48.3X5T48.3X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.