2024 ICD-10-CM Diagnosis Code T43.505

Adverse effect of unspecified antipsychotics and neuroleptics

ICD-10-CM Code:
T43.505
ICD-10 Code for:
Adverse effect of unsp antipsychotics and neuroleptics
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified
        (T43)

T43.505 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of unspecified antipsychotics and neuroleptics. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Unspecified diagnosis codes like T43.505 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

Specific Coding Applicable to Adverse effect of unsp antipsychotics and neuroleptics

Non-specific codes like T43.505 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of unsp antipsychotics and neuroleptics:

  • Use T43.505A for initial encounter - BILLABLE CODE

  • Use T43.505D for subsequent encounter - BILLABLE CODE

  • Use T43.505S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Acute akathisia caused by drug
  • Acute akathisia caused by neuroleptic
  • Akathisia
  • Akathisia caused by drug
  • Drug-induced dyskinesia
  • Neuroleptic adverse reaction
  • Neuroleptic malignant syndrome
  • Neuroleptic-induced parkinsonism
  • Neuroleptic-induced tardive dyskinesia
  • Parkinsonism due to drug
  • Post-injection delirium sedation syndrome
  • Restlessness
  • Subacute dyskinesia due to drug
  • Tardive dyskinesia

Clinical Information

  • Tardive Dyskinesia

    drug-related movement disorder characterized by uncontrollable movements in certain muscles. it is associated with a long-term exposure to certain neuroleptic medications (e.g., metoclopramide).
  • Neuroleptic Malignant Syndrome

    a potentially fatal syndrome associated primarily with the use of neuroleptic agents (see antipsychotic agents) which are in turn associated with dopaminergic receptor blockade (see receptors, dopamine) in the basal ganglia and hypothalamus, and sympathetic dysregulation. clinical features include diffuse muscle rigidity; tremor; high fever; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. serum cpk level elevation and a leukocytosis may also be present. (from adams et al., principles of neurology, 6th ed, p1199; psychiatr serv 1998 sep;49(9):1163-72)
  • Metoclopramide

    a dopamine d2 antagonist that is used as an antiemetic.
  • Akathisia

    an uncomfortable feeling of inner restlessness and inability to stay still. it can be a side effect of psychotropic medications.
  • Akathisia, CTCAE|Akathisia|Akathisia

    a disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.
  • Barnes Akathisia Rating Scale Clinical Classification|BARS|BARS|BARS01

    a standardized rating scale developed by thomas r. e. barnes in 1989 to diagnose akathisia associated with use of antipsychotic agents. this instrument contains objective and subjective sections, as well as a global clinical assessment of akathisia. the first two sections contain a total of 3 items which are rated on a scale of 0 to 3 with 0 being none or normal and 3 being severe. the third section is rated on a 0 to 5 scale with 0 being none and 5 being severe.
  • CDISC Clinical Classification BARS Test Code Terminology|BARS01TC|Barnes Akathisia Rating Scale Clinical Classification Test Code|QS-BARS TESTCD

    test codes of clinical classification questions associated with the barnes akathisia rating scale (bars) for the clinical data interchange standards consortium (cdisc) standard data tabulation model (sdtm).
  • CDISC Clinical Classification BARS Test Name Terminology|BARS01TN|Barnes Akathisia Rating Scale Clinical Classification Test Name|QS-BARS TEST

    test names of clinical classification questions associated with the barnes akathisia rating scale (bars) for the clinical data interchange standards consortium (cdisc) standard data tabulation model (sdtm).
  • Drug-Induced Akathisia|Drug induced akathisia

    evidence of drug-induced akathisia.
  • ESRS-A - Akathisia: Objective|ESRSA1-Akathisia: Objective|ESRSA1-Akathisia: Objective|ESRSA124

    extrapyramidal symptom rating scale-abbreviated (esrs-a) akathisia: objective.
  • ESRS-A - Akathisia: Subjective|ESRSA1-Akathisia: Subjective|ESRSA1-Akathisia: Subjective|ESRSA123

    extrapyramidal symptom rating scale-abbreviated (esrs-a) akathisia: subjective.
  • ESRS-A - CGI-S Akathisia|ESRSA1-CGI-S Akathisia|ESRSA1-CGI-S Akathisia|ESRSA128

    extrapyramidal symptom rating scale-abbreviated (esrs-a) clinical global impression (cgi-s): akathisia.
  • Grade 1 Akathisia, CTCAE|Grade 1 Akathisia

    mild restlessness or increased motor activity
  • Grade 2 Akathisia, CTCAE|Grade 2 Akathisia

    moderate restlessness or increased motor activity; limiting instrumental adl
  • Grade 3 Akathisia, CTCAE|Grade 3 Akathisia

    severe restlessness or increased motor activity; limiting self care adl

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (T43). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Antianxiety drug NECT43.501T43.502T43.503T43.504T43.505T43.506
AntihallucinogenT43.501T43.502T43.503T43.504T43.505T43.506
Antipsychotic drugT43.501T43.502T43.503T43.504T43.505T43.506
Antipsychotic drug
  »specified NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Ataractic drug NECT43.501T43.502T43.503T43.504T43.505T43.506
Neuroleptic drug NECT43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NECT43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »with hypnotic or sedative
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »benzodiazepine NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »butyrophenone NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »carbamate
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »dimethylamine
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »ethylamine
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »hydroxyzine
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »major NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »penothiazine NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »phenothiazine-based
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »piperazine NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »piperidine
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »propylamine
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »specified NEC
T43.501T43.502T43.503T43.504T43.505T43.506
Tranquilizer NEC
  »thioxanthene NEC
T43.501T43.502T43.503T43.504T43.505T43.506

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.