2024 ICD-10-CM Diagnosis Code T38.1X5

Adverse effect of thyroid hormones and substitutes

ICD-10-CM Code:
T38.1X5
ICD-10 Code for:
Adverse effect of thyroid hormones and substitutes
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified
        (T38)

T38.1X5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of thyroid hormones and substitutes. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Adverse effect of thyroid hormones and substitutes

Non-specific codes like T38.1X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of thyroid hormones and substitutes:

  • Use T38.1X5A for initial encounter - BILLABLE CODE

  • Use T38.1X5D for subsequent encounter - BILLABLE CODE

  • Use T38.1X5S for sequela - BILLABLE CODE

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction to thyroglobulin
  • Adverse reaction to thyroid hormone
  • Dextrothyroxine sodium adverse reaction
  • Hypothyroidism due to iodide excess
  • Liothyronine adverse reaction
  • Thyrotoxicosis on thyroxine therapy
  • Thyroxine adverse reaction

Clinical Information

  • Correspondence as Topic

    works on written communication between persons or between institutions or organizations.
  • Histiocytosis, Langerhans-Cell

    a group of disorders resulting from the abnormal proliferation of and tissue infiltration by langerhans cells which can be detected by their characteristic birbeck granules (x bodies), or by monoclonal antibody staining for their surface cd1 antigens. langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
  • Letter

    work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. the correspondence may be personal or professional. in medical and other scientific publications the letter is usually from one or more authors to the editor of the journal or book publishing the item being commented upon or discussed. letter is often accompanied by comment.
  • Thyroglobulin

  • Iodide Peroxidase

    a hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. ec 1.11.1.8.
  • Receptors, Thyroid Hormone

    specific high affinity binding proteins for thyroid hormones in target cells. they are usually found in the nucleus and regulate dna transcription. these receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. thyroid hormone receptors are encoded by two genes (genes, erba): erba-alpha and erba-beta for alpha and beta thyroid hormone receptors, respectively.
  • Thyroxine

    the major hormone derived from the thyroid gland. thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
  • Thyroxine-Binding Globulin

    a thyroid hormone transport protein found in serum. it binds about 75% of circulating thyroxine and 70% of circulating triiodothyronine.
  • Thyroxine-Binding Proteins

    blood proteins that bind to thyroid hormones such as thyroxine and transport them throughout the circulatory system.
  • Triiodothyronine

    a t3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (t4). most t3 is derived from peripheral monodeiodination of t4 at the 5' position of the outer ring of the iodothyronine nucleus. the hormone finally delivered and used by the tissues is mainly t3.
  • Triiodothyronine, Reverse

    a metabolite of thyroxine, formed by the peripheral enzymatic monodeiodination of t4 at the 5 position of the inner ring of the iodothyronine nucleus.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (T38). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
CytomelT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
DetrothyronineT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
DextrothyroxinT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
Dextrothyroxine sodiumT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
EuthroidT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
I-thyroxine sodiumT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
LetterT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
LevoidT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
LevothyroxineT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
Levothyroxine
  »sodium
T38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
LiothyronineT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
LiotrixT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
ProloidT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
SynthroidT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
ThyroglobulinT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
Thyroid (hormone)T38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
ThyrolarT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
ThyroxineT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
TiratricolT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
TitroidT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6
TriiodothyronineT38.1X1T38.1X2T38.1X3T38.1X4T38.1X5T38.1X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.