Version 2024
No Valid Principal Dx

2024 ICD-10-CM Diagnosis Code R89.8

Other abnormal findings in specimens from other organs, systems and tissues

ICD-10-CM Code:
R89.8
ICD-10 Code for:
Oth abnormal findings in specimens from oth org/tiss
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
    (R00–R99)
    • Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
      (R83-R89)
      • Abnormal findings in specimens from other organs, systems and tissues
        (R89)

R89.8 is a billable diagnosis code used to specify a medical diagnosis of other abnormal findings in specimens from other organs, systems and tissues. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Abnormal amino acid sequence
  • Abnormal amniotic fluid
  • Abnormal bone marrow iron
  • Abnormal carbohydrate sequence
  • Abnormal consistency
  • Abnormal macromolecular binding
  • Abnormal macromolecular sequence
  • Abnormal molecular cross-linking
  • Abnormal nucleic acid sequence
  • Abnormal nucleotide base sequence
  • Abnormal organ weight
  • Abnormal presence of galactose
  • Abnormal presence of glucose
  • Abnormal presence of hemoglobin
  • Abnormal presence of myoglobin
  • Abnormal presence of pentose
  • Abnormal presence of protein
  • Abnormal size
  • Abnormal structure of cerebroside
  • Abnormal structure of phospholipid
  • Abnormal structure of physiologic substance
  • Abnormal thickness
  • Abnormal translucency
  • Abnormally decreased organ weight
  • Abnormally hard consistency
  • Abnormally increased laxity
  • Abnormally increased organ weight
  • Abnormally soft consistency
  • Absent bone marrow iron
  • Acellular smear
  • Aceto-white reaction finding
  • Aceto-white reaction positive
  • Adenylic acid above reference range
  • Adenylic acid below reference range
  • Allelic exclusion
  • Alpha-fetoprotein above reference range
  • Alteration of genetic material
  • Amino acid above reference range
  • Amino acid below reference range
  • Amniotic fluid AFP - finding
  • Amniotic fluid AFP - finding
  • Amniotic fluid alpha-fetoprotein above reference range
  • Amniotic fluid alpha-fetoprotein outside reference range
  • Amniotic fluid volume below reference range
  • Ascorbic acid above reference range
  • Ascorbic acid below reference range
  • Beta amino isobutyric acid above reference range
  • Beta amino isobutyric acid below reference range
  • Bilirubin level - finding
  • Bilirubin level below reference range
  • Biliverdin above reference range
  • Bone marrow erythropoiesis - finding
  • Bone marrow erythropoiesis - finding
  • Bone marrow erythropoiesis - finding
  • Bone marrow erythropoiesis hyperplasia
  • Bone marrow iron finding
  • Bone marrow iron finding
  • Bone marrow megaloblastic
  • Bone marrow normoblastic
  • Breast cancer genetic marker of susceptibility detected
  • Calculus = bilirubin
  • Calculus = carbaptite
  • Calculus = cholesterol
  • Calculus = hydroxyapatite
  • Calculus = phosphate
  • Calculus = triple phosphate
  • Calculus chemical composition - finding
  • Cancer antigen 27-29 above reference range
  • Carbohydrate above reference range
  • Carbohydrate below reference range
  • Carbohydrate conformation
  • Cell chromosome examination abnormal
  • Cell division alteration
  • Cell division alteration
  • Cell division alteration
  • Cell division alteration
  • Cell division alteration
  • Cholesterol/high density lipoprotein ratio above reference range
  • Choline above reference range
  • Choline below reference range
  • Cold agglutinins detected
  • Contact sensitivity response - finding
  • Contraction
  • CYP2C19 rapid metabolizer
  • CYP2C9 poor metabolizer
  • CYP2C9 poor metabolizer
  • Cystine above reference range
  • Cystine below reference range
  • Cytochrome P450 family 1 subfamily A member 2 poor metabolizer
  • Cytochrome P450 family 1 subfamily A member 2 rapid metabolizer
  • Cytochrome P450 family 1 subfamily A member 2 ultra-rapid metabolizer
  • Cytochrome P450 family 2 subfamily C member 9 *2/*3 poor metabolizer
  • Cytochrome P450 family 2 subfamily C member 9 *3/*3 poor metabolizer
  • Cytochrome P450 family 2 subfamily C member 9 rapid metabolizer
  • Cytochrome P450 family 2 subfamily C member 9 ultra-rapid metabolizer
  • Cytochrome P450 family 2 subfamily D member 6 rapid metabolizer
  • Cytochrome P450 family 3 subfamily A member 4 poor metabolizer
  • Cytochrome P450 family 3 subfamily A member 4 rapid metabolizer
  • Cytochrome P450 family 3 subfamily A member 4 ultra-rapid metabolizer
  • Cytochrome P450 family 3 subfamily A member 5 ultra-rapid metabolizer
  • Cytochrome P450 family 4 subfamily F member 2 poor metabolizer
  • Decrease in circumference
  • Decreased cell mitotic activity
  • Decreased ceroid
  • Decreased diameter
  • Decreased macromolecular binding
  • Decreased molecular dissociation
  • Decreased size
  • Decreased thickness
  • Decreased translucency
  • Defective molecular assembly
  • Denaturation
  • Depolymerization
  • DNA damage
  • Down syndrome detected by multiple marker screening
  • Effect of antiestrogen agent
  • Extra chromosomal inheritance
  • Fetal anomaly present in specimen
  • Fetal tissue present in specimen
  • Fibrinogen below reference range
  • Finding by inspection
  • Finding by inspection
  • Finding of amniotic fluid volume
  • Finding of organ weight
  • Finding of organ weight
  • Finding of organ weight
  • Finding of oxygen saturation
  • Finding of vitamin B12 level
  • Finding related to physiologic substance
  • Finding related to physiologic substance
  • Finding related to physiologic substance
  • Finding related to physiologic substance
  • Folic acid above reference range
  • Folic acid below reference range
  • Frame-shift mutation
  • Fructose above reference range
  • Fructose below reference range
  • Galactose above reference range
  • Galactose below reference range
  • Gene amplification
  • Gene re-arrangement
  • Gene re-arrangement, alpha chain, T cell antigen receptor
  • Gene re-arrangement, B lymphocyte
  • Gene re-arrangement, B lymphocyte, heavy chain
  • Gene re-arrangement, B lymphocyte, light chain
  • Gene re-arrangement, beta chain, T cell antigen receptor
  • Gene re-arrangement, gamma chain, T cell antigen receptor
  • Gene re-arrangement, T lymphocyte
  • Genetic finding detected
  • Genetic inversion
  • Genetic linkage disequilibrium
  • Genetic linkage equilibrium
  • Genetic mosaic
  • Genetic mutation
  • Genetic susceptibility to cancer
  • Genetic susceptibility to genetic disorder
  • Genetic susceptibility to malignant hyperthermia due to calcium voltage-gated channel subunit alpha1 S gene mutation
  • Globulin below reference range
  • Glucose level above reference range
  • Glycogen above reference range
  • Glycogen below reference range
  • Granulocyte count below reference range
  • GU test finding
  • Heterozygous protocadherin 19 gene mutation detected
  • Histidine above reference range
  • Histidine below reference range
  • Homogentisic acid above reference range
  • Human epidermal growth factor receptor 2 gene amplification detected
  • Human papillomavirus deoxyribonucleic acid detected
  • Increase in circumference
  • Increased cell mitotic activity
  • Increased ceroid
  • Increased diameter
  • Increased macromolecular binding
  • Increased molecular dissociation
  • Increased nuchal translucency detected by multiple marker screening
  • Increased translucency
  • Inequality in circumference
  • Influenza A H1N1 virus 2009 pandemic strain present
  • Influenza A virus subtype H1 present
  • Karyotype evaluation abnormal
  • Keratin, type I cytoskeletal 19 fragment above reference range
  • Ketone bodies above reference range
  • Lactic acid level above reference range
  • Lactose above reference range
  • Lactose below reference range
  • Laxity
  • Macromolecular alteration
  • Macromolecular binding
  • Macromolecular cleavage
  • Macromolecular defective synthesis
  • Macromolecular nicking
  • Malignant hyperthermia genetic susceptibility
  • Mannoheptulose above reference range
  • Mannoheptulose below reference range
  • Measurement finding above reference range
  • Measurement finding below reference range
  • Meiotic alteration
  • Methemalbumin above reference range
  • Methemalbumin below reference range
  • Mitochondrial 1555 A to G mutation detected
  • Mitochondrial mutation
  • Mitotic alteration
  • Mitotic arrest
  • Molecular conformation
  • Molecular degradation
  • Molecular dissociation
  • Molecular inactivation
  • Molecular instability
  • Monocyte count - finding
  • Monocyte count outside reference range
  • Mucopurulent
  • N-acetyltransferase 2 slow acetylator
  • Needle shaped crystals present
  • Nonsense mutation
  • Nucleic acid conformation
  • Nucleotide base deletion
  • Orotic acid above reference range
  • Orotic acid below reference range
  • Oxygen saturation above reference range
  • Pentose above reference range
  • Pentose below reference range
  • Phosphate kidney stone
  • Point mutation
  • Porphyrin below reference range
  • Positive skin test reaction
  • Presence of crystals - finding
  • Presence of ova cysts and parasites - finding
  • Protein conformation
  • Protein electrophoresis outside reference range
  • Protein-bound iodine below reference range
  • Quantity of physiologic substance outside reference range
  • Retraction
  • Sample grossly hemolyzed
  • Sample grossly icteric
  • Sample grossly lipemic
  • Sample hemolyzed
  • Sample hemolyzed
  • Sample icteric
  • Sample icteric
  • Sample lipemic
  • Sample lipemic
  • Sample slightly hemolyzed
  • Sample slightly icteric
  • Sample slightly lipemic
  • Satisfactory for evaluation but limited by partially obscuring air drying artifact
  • Satisfactory for evaluation but limited by partially obscuring thick areas
  • Shrinkage
  • Snowstorm knee
  • Somatic mutation
  • Specific gravity - finding
  • Specific gravity above reference range
  • Specimen involvement by multifocal invasion
  • Specimen too thick for optimal interpretation
  • Strand breaks
  • Stringing of synovial fluid
  • Superhelicity
  • Suppressor mutation
  • Suture material present
  • Synovial fluid appearance - finding
  • Synovial fluid appearance - finding
  • Synovial fluid appearance - finding
  • Synovial fluid appearance - finding
  • Synovial fluid appearance - finding
  • Synovial fluid appearance - finding
  • Synovial fluid bloodstained
  • Synovial fluid cloudy
  • Synovial fluid composition - finding
  • Synovial fluid composition - finding
  • Synovial fluid composition - finding
  • Synovial fluid composition - finding
  • Synovial fluid composition - finding
  • Synovial fluid fibrin clot
  • Synovial fluid fibrin clot
  • Synovial fluid turbid
  • Synovial fluid viscosity - finding
  • Synovial fluid viscosity - finding
  • Synovial fluid viscosity high
  • Synovial fluid viscosity low
  • Synovial fluid yellow
  • Synovial fluid: abnormal content
  • Synovial fluid: abnormal content
  • Synovial fluid: abnormal content
  • Synovial fluid: crystals
  • Synovial fluid: fibrin clot +
  • Synovial fluid: pyrophosphate
  • Synovial fluid: uric acid
  • Temperature-sensitive mutation
  • Thyroid hormone level below reference range
  • Tissue specimen fragmented
  • Tissue specimen ruptured
  • Translucency finding
  • Translucency finding
  • Translucency finding
  • Trisomy 18 detected by multiple marker screening
  • Tumor protein p53 detected
  • Tyrosine above reference range
  • Tyrosine below reference range
  • Uncertain malignant hyperthermia predisposition due to RyR1 gene mutation
  • Uric acid level below reference range
  • Urobilin above reference range
  • Urobilin below reference range
  • Urobilinogen level above reference range
  • Urobilinogen level below reference range
  • Uroporphyrin below reference range
  • Vanillylmandelic acid level above reference range
  • Vanillylmandelic acid level below reference range
  • Vesicular reaction
  • Vitamin A above reference range
  • Vitamin B below reference range
  • Vitamin B12 above reference range
  • Vitamin D above reference range
  • Vitamin E above reference range
  • Vitamin K above reference range
  • Vitamin K epoxide reductase complex 1 poor metabolizer
  • Vitamin K epoxide reductase complex 1 rapid metabolizer
  • Vitamin K epoxide reductase complex 1 ultra-rapid metabolizer
  • Xanthine above reference range
  • Xanthine below reference range

Clinical Classification

Clinical Information

  • Gene Amplification

    a selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. it occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an rna transcript of the entire repeating sequence of ribosomal rna followed by the reverse transcription of the molecule to produce an additional copy of the original dna sequence. laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of dna from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
  • Nucleic Acid Conformation

    the spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
  • Point Mutation

    a mutation caused by the substitution of one nucleotide for another. this results in the dna molecule having a change in a single base pair.
  • Protein Conformation

    the characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. protein structure, quaternary describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
  • Protein Conformation, alpha-Helical

    a secondary structure of proteins that is a right-handed helix or coil, where each amino (n-h) group of the peptide backbone contributes a hydrogen bond to the carbonyl(c=o) group of the amino acid four residues n-terminal to it (n-4). it is the most common type of secondary structure.
  • Protein Conformation, beta-Strand

    a secondary structure of proteins where the amino (n-h) groups of a polypeptide backbone, three to ten amino acids in length, establish hydrogen bonds with the carbonyl (c=o) groups in the backbone of adjacent strands. these may form a beta-sheet, where the side chains of the adjacent strands point in the same direction.
  • Carbohydrate Conformation

    the characteristic 3-dimensional shape of a carbohydrate.
  • DNA Damage

    injuries to dna that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a mutation or a block of dna replication. these deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. they include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the dna backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (pyrimidine dimers) or interstrand crosslinking. damage can often be repaired (dna repair). if the damage is extensive, it can induce apoptosis.
  • Oxidative Stress

    a disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. indicators of oxidative stress include damaged dna bases, protein oxidation products, and lipid peroxidation products (sies, oxidative stress, 1991, pxv-xvi).
  • Transcription Factor CHOP

    a ccaat-enhancer binding protein that is induced by dna damage and growth arrest. it serves as a dominant negative inhibitor of other ccaat-enhancer binding proteins.
  • Molecular Conformation

    the characteristic three-dimensional shape of a molecule.
  • DNA

    a deoxyribonucleotide polymer that is the primary genetic material of all cells. eukaryotic and prokaryotic organisms normally contain dna in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. dna, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
  • Depolymerization

    the process that catabolizes the covalent bonds between monomeric structures in a polymer.
  • Microtubule Depolymerization Process|Disassembly of Microtubules|Microtubule Depolymerization

    any microtubule process involving the removal of tubulin heterodimers from one or both ends of a microtubule.
  • Negative Regulation of Microtubule Depolymerization|Microtubule Disassembly Inhibition|Microtubule Stabilization

    any microtubule process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization.
  • Semuloparin|AVE-5026|AVE5026|SEMULOPARIN|ULMW heparin AVE5026|Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization)|Ultralow-Molecular-Weight Heparin AVE5026

    an ultralow-molecular-weight heparin (ulmwh) (mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. ultralow-molecular-weight heparin ave5026 binds to and activates antithrombin iii (atiii), which may result in the inhibition of activated factor xa and, to a much lesser extent, factor iia (thrombin) and so the inhibition of fibrin formation. compared to low-molecular-weight heparins (lmwhs), ave5026 exhibits an even higher ratio of anti-factor xa to anti-factor iia activity (>30:1). compared to unfractionated heparins, the use of lmwhs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. like lmwhs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. ave5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.
  • DDIT3 Gene Rearrangement|C/EBPzeta Gene Rearrangement|CEBPZ Gene Rearrangement|CHOP-10 Gene Rearrangement|CHOP10 Gene Rearrangement|DDIT3 Rearrangement|DNA Damage Inducible Transcript 3 Gene Rearrangement|DNA-Damage-Inducible Transcript 3 Gene Rearrangement|GADD153 Gene Rearrangement

    a molecular abnormality indicating rearrangement of the ddit3 gene.
  • DDIT3 Gene|CHOP|DDIT3|DDIT3|DDIT3|DNA Damage Inducible Transcript 3 Gene

    this gene plays a role in the modulation of transcription.
  • DDIT3 wt Allele|C/EBP Zeta Gene|C/EBPzeta|CCAAT/Enhancer-Binding Protein Homologous Protein Zeta Gene|CEBPZ|CHOP|CHOP-10|CHOP10|DNA Damage Inducible Transcript 3 wt Allele|DNA-Damage-Inducible Transcript 3 Gene|GADD153|Growth Arrest- and DNA Damage-Inducible 153 Gene|MGC4154

    human ddit3 wild-type allele is located in the vicinity of 12q13.3 and is approximately 4 kb in length. this allele, which encodes dna damage-inducible transcript 3 protein, is involved in transcriptional suppression. two translocations involving the gene, t(12;16)(q13;p11) with the fus gene and t(12;22)(q13;q12) with the ewsr1 gene, are associated with myxoid liposarcoma.
  • DDRD Signature|DDRD Gene Signature|DNA Damage Response Deficiency Gene Signature|DNA Damage Response Deficiency Signature

    a gene expression profile that indicates that the cells in a sample have decreased ability to respond to and repair dna damage.
  • Deleterious DNA Damage Response Gene Mutation|DDR Deleterious Gene Alteration|DDR Gene Deleterious Alteration|Deleterious DDR Gene Mutation|Deleterious DNA Damage Response (DDR) Gene Alteration|Deleterious DNA Damage Response Gene Alteration

    a change in the nucleotide sequence of a gene involved in any dna damage response pathway that is associated with increased risk of disease.
  • DINOL wt Allele|DINO|DNA Damage, p53 is Stabilized and p53-Responsive Gene|Damage Induced Long Noncoding RNA wt Allele|Damage Induced Noncoding RNA Gene|Damage-Induced Non-Coding RNA Gene

    human dinol wild-type allele is located in the vicinity of 6p21.2 and is approximately 1 kb in length. this allele, which encodes damage induced long noncoding rna, plays a role in stabilization of cellular tumor antigen p53.
  • DNA Damage

    drug-, radiation-induced, or spontaneous injuries to dna that introduce deviations from its normal double-helical conformation. these changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in dna sequence. if the damage is minor, it can often be repaired (dna repair); extensive damage can induce apoptosis.
  • DNA Damage Response Deficiency|DDRD|DNA Damage Repair Deficiency|DNA Damage Response and Repair Deficiency|Deficient DNA Damage Response

    a decrease in the ability of cells to respond to damaged dna and to repair the damage. this dna repair deficiency can be caused by mutations in the genes involved in the dna damage response and/or dna repair.
  • DNA Damage Response Gene Mutation|DDR Gene Alteration|DDR Gene Mutation|DNA Damage Response Gene Alteration|DNA Damage Response Gene Alteration

    any change in the nucleotide sequence of a gene involved in dna damage response pathways.
  • DNA Damage-Binding Protein 1|DDB p127 Subunit|DDB1|DDBa|DNA Damage-Binding Protein a|Damage-Specific DNA-Binding Protein 1|HBV X-Associated Protein 1|UV-DDB 1|UV-Damaged DNA-Binding Factor|UV-Damaged DNA-Binding Protein 1|XAP-1|XPE-BF|XPE-Binding Factor|Xeroderma Pigmentosum Group E-Complementing Protein

    dna damage-binding protein 1 (1140 aa, ~127 kda) is encoded by the human ddb1 gene. this protein is involved in both protein ubiquitination and dna damage repair.
  • DNA Damage-Binding Protein 2|DDB p48 Subunit|DDB2|DDBb|DNA Damage-Binding Protein b|Damage-Specific DNA-Binding Protein 2|UV-DDB 2|UV-Damaged DNA-Binding Protein 2

    dna damage-binding protein 2 (427 aa, ~48 kda) is encoded by the human ddb2 gene. this protein plays a role in the mediation of dna repair.
  • DNA Damage-Inducible Transcript 3 Protein|C/EBP-Homologous Protein|C/EBP-Homologous Protein 10|CHOP|CHOP-10|DDIT-3|DDIT3|Growth Arrest and DNA Damage-Inducible Protein GADD153

    dna damage-inducible transcript 3 protein (169 aa, ~19 kda) is encoded by the human ddit3 gene. this protein plays a role in the sequestration of transcription factors.
  • DNA Damage-Inducible Transcript 4 Protein|HIF-1 Responsive Protein|Protein Regulated in Development and DNA Damage Response 1|RTP801

    dna damage-inducible transcript 4 protein (232 aa, ~25 kda) is encoded by the human ddit4 gene. this protein is involved in responses to cellular stress and regulates apoptosis in response to dna damage.
  • DNA Repair|DNA Damage Repair|Unscheduled DNA Synthesis

    enzymatic restoration of dna structure after chemical, radiation, or spontaneous damage.
  • EWSR1/DDIT3 Fusion Protein|EWS-CHOP Fusion Protein|EWS/CHOP Fusion Protein|EWSR1-DDIT3 Fusion Protein|EWSR1::DDIT3 Fusion Protein|RNA-Binding Protein EWS/DNA Damage-Inducible Transcript 3 Protein Fusion Protein

    a fusion protein encoded by the ewsr1/ddit3 fusion gene. this protein is comprised of the transactivation domain of the rna-binding protein ews followed by the dna-binding basic domain and leucine zipper dimerization domain of the dna damage-inducible transcript 3 protein.
  • FUS/DDIT3 Fusion Protein|FUS-CHOP Fusion Protein|FUS-DDIT3 Fusion Protein|FUS/CHOP Fusion Protein|FUS::DDIT3 Fusion Protein|RNA-Binding Protein FUS/DNA Damage-Inducible Transcript 3 Protein Fusion Protein|TLS-CHOP Fusion Protein|TLS/CHOP Fusion Protein

    a fusion protein encoded by the fus/ddit3 fusion gene. this protein is comprised of at least half of the rna-binding protein fus followed by the dna-binding basic domain and leucine zipper dimerization domain of the dna damage-inducible transcript 3 protein.
  • GADD45A Gene|GADD45A|GADD45A|Growth Arrest and DNA Damage Inducible Alpha Gene

    this gene plays a role in signal transduction and is induced in response to environmental stress. it is involved in apoptosis, dna repair and negative regulation of cell growth.
  • GADD45A wt Allele|DDIT1|DNA Damage-Inducible Gene Gadd45|DNA Damage-Inducible Transcript 1 Gene|DNA Damage-Inducible Transcript-1 Gene|DNA-Damage-Inducible Transcript 1 Gene|GADD45|Growth Arrest and DNA Damage Inducible Alpha wt Allele|Growth Arrest and DNA Damage-Inducible Gene 45|Growth Arrest and DNA-Damage-Inducible, Alpha Gene|Growth Arrest- and DNA Damage-Inducible Gene GADD45, Alpha|RP5-975D15.1

    human gadd45a wild-type allele is located within 1p31.2-p31.1 and is approximately 3 kb in length. this allele, which encodes growth arrest and dna-damage-inducible protein gadd45 alpha, is involved in the modulation of cellular responses to environmental stress.
  • Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha|DDIT-1|DNA Damage-Inducible Transcript 1 Protein|GADD45 Gene Product|GADD45A|GADD45A Protein|Growth Arrest and DNA Damage-Inducible Gene 45 Protein|Growth Arrest and DNA-Damage-Inducible 45 Alpha|Growth Arrest and DNA-Damage-Inducible, Alpha

    growth arrest and dna damage-inducible protein gadd45 alpha (165 aa, ~18 kda) is encoded by the human gadd45a gene. this protein is involved in the regulation of mitogenic signaling.
  • Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta|GADD45B|Growth Arrest and DNA-Damage-Inducible Beta|Myeloid Differentiation Primary Response Protein MyD118|Negative Growth Regulatory Protein MyD118

    growth arrest and dna damage-inducible protein gadd45 beta (160 aa, ~18 kda) is encoded by the human gadd45b gene. this protein plays a role in the regulation of cell growth, apoptosis and signaling.
  • Interferon-Related DNA Damage Resistance Gene Signature|IFN-Related DNA Damage Resistance Signature|IRDS

    an experimental therapy-predictive system used to assess if patient's tumor may be resistant to chemotherapy. this system is based on the expression profile of a panel of genes that are associated with both interferon signaling pathways and resistance to radiation-induced dna damage.
  • MDC1 Gene Mutation|Mediator of DNA Damage Checkpoint 1 Gene Mutation|NFBD1 Gene Mutation

    a change in the nucleotide sequence of the mdc1 gene.
  • MDC1 Gene|MDC1|MDC1|Mediator of DNA Damage Checkpoint 1 Gene

    this gene plays a role in cell cycle progression.
  • MDC1 wt Allele|Em:AB023051.5|KIAA0170|Mediator of DNA Damage Checkpoint 1 wt Allele|Mediator of DNA-Damage Checkpoint 1 Gene|NFBD1

    human mdc1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 18 kb in length. this allele, which encodes mediator of dna damage checkpoint protein 1, is involved in checkpoint mediated cell cycle arrest.
  • Mediator of DNA Damage Checkpoint Protein 1|Homolog to Drosophila Photoreceptor Protein Calphotin|MDC1|Mediator of DNA Damage Checkpoint 1|Nuclear Factor with BRCT Domains 1

    mediator of dna damage checkpoint protein 1 (2089 aa, ~227 kda) is encoded by the human mdc1 gene. this protein plays a role in checkpoint mediated cell cycle arrest.
  • Oxidative DNA Damage|DNA Oxidation|Oxidative Damage of DNA

    the oxidation of deoxyribonucleosides in dna strands, which may occur due to exposure to reactive oxygen species (ros). under normal conditions, low levels of oxidized nucleosides are present; this steady state level may play a role epigenetic control of gene expression and is maintained by enzymes of the base excision repair (ber) pathway. elevated levels of oxidative dna damage are associated with oxidative stress, tumorigenesis and certain diseases, including neurologic conditions such as alzheimer disease, systemic lupus erythematosus, bipolar disorder and schizophrenia.
  • Protein Phosphatase 1 Regulatory Subunit 15A|Growth Arrest and DNA Damage-Inducible Protein GADD34|Myeloid Differentiation Primary Response Protein MyD116 Homolog

    protein phosphatase 1 regulatory subunit 15a (674 aa, ~73 kda) is encoded by the human ppp1r15a gene. this protein is involved in both signaling and phosphatase recruitment.
  • Radiation Induced DNA Damage|DNA Damage, Radiation Induced|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage

    damage to dna caused by ionizing radiation. can cause base change mutations or strand breakage.
  • Radiation Induced DNA Damage|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage

    damage to dna caused by ionizing radiation. can cause base change mutations or strand breakage.
  • Tumor Necrosis Factor Receptor Superfamily Member 10B|Apoptosis Inducing Protein TRICK2A/2B|Apoptosis Inducing Receptor TRAIL-R2|CD262 Antigen|Cytotoxic TRAIL Receptor-2|DR5|DR5|Death Domain Containing Receptor For TRAIL/Apo-2L|Death Receptor 5|Fas-Like Protein|Fas-Like Protein Precursor|P53-Regulated DNA Damage-Inducible Cell Death Receptor (Killer)|TNF Receptor Superfamily Member 10b|TNF-Related Apoptosis-Inducing Ligand Receptor 2|TNFRSF10B|TRAIL Receptor 2|TRAIL receptor 2|TRAIL-R2|TRAIL-R2|TRAILR-2|TRAILR2|Tumor Necrosis Factor Receptor-Like Protein ZTNFR9|death receptor 5|tumor necrosis factor receptor superfamily member 10B

    tumor necrosis factor receptor superfamily member 10b (440 aa, ~48 kda) is encoded by the human tnfrsf10b gene. this protein is involved in the modulation of the caspase cascade.
  • XPC Gene Mutation|RAD4 Gene Mutation|XP3 Gene Mutation|XPC Complex Subunit, DNA Damage Recognition and Repair Factor Gene Mutation|XPCC Gene Mutation|Xeroderma Pigmentosum, Complementation Group C Gene Mutation

    a change in the nucleotide sequence of the xpc gene.
  • XPC Gene|XPC|XPC|XPC|XPC|XPC Complex Subunit, DNA Damage Recognition and Repair Factor Gene

    this gene is involved in nucleotide excision repair.
  • XPC wt Allele|RAD4|RAD4, Yeast, Homolog of Gene|XP3|XPC Complex Subunit, DNA Damage Recognition and Repair Factor wt Allele|XPCC|Xeroderma Pigmentosum, Complementation Group C Gene

    human xpc wild-type allele is located in the vicinity of 3p25 and is approximately 34 kb in length. this allele, which encodes dna repair protein complementing xp-c cells protein, plays a role in the regulation of nucleotide excision repair. mutation of the gene is associated with xeroderma pigmentosum complementation group c.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Abnormal chromosomal findings in specimens from other organs, systems and tissues

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert R89.8 to ICD-9-CM

  • ICD-9-CM Code: 792.9 - Abn find-body subst NEC
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
  • ICD-9-CM Code: 795.2 - Abn chromosomal analysis
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.