Version 2024
Replaced Code

2024 ICD-10-CM Diagnosis Code G93.49

Other encephalopathy

ICD-10-CM Code:
G93.49
ICD-10 Code for:
Other encephalopathy
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

Code Classification

  • Diseases of the nervous system
    (G00–G99)
    • Other disorders of the nervous system
      (G89-G99)
      • Other disorders of brain
        (G93)

G93.49 is a billable diagnosis code used to specify a medical diagnosis of other encephalopathy. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • 4H leukodystrophy
  • Acute encephalopathy with biphasic seizures and late reduced diffusion
  • Autoimmune encephalopathy with parasomnia and obstructive sleep apnea
  • Autosomal recessive leukoencephalopathy, ischemic stroke, retinitis pigmentosa syndrome
  • Autosomal recessive spastic ataxia with leukoencephalopathy
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
  • Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
  • Cerebral degeneration due to cerebrovascular disease
  • Cerebral degeneration in childhood
  • CLCN2-related leukoencephalopathy
  • COL4A1-related familial vascular leukoencephalopathy
  • Cystic leukoencephalopathy without megalencephaly
  • Distal spinal muscular atrophy
  • Early infantile epileptic encephalopathy with suppression bursts
  • Early-onset calcifying leukoencephalopathy, skeletal dysplasia
  • Early-onset progressive encephalopathy, hearing loss, pons hypoplasia, brain atrophy syndrome
  • Early-onset progressive encephalopathy, spastic ataxia, distal spinal muscular atrophy syndrome
  • Encephalopathy due to Influenza A virus
  • Familial encephalopathy with neuroserpin inclusion bodies
  • Hereditary diffuse leukoencephalopathy with spheroids
  • Human immunodeficiency virus leukoencephalopathy
  • Hypomyelination and congenital cataract
  • Infantile encephalopathy AND lactic acidosis
  • Late tooth eruption
  • Leukoencephalopathy
  • Leukoencephalopathy co-occurrent with bilateral anterior temporal lobe cysts
  • Leukoencephalopathy due to copper deficiency
  • Leukoencephalopathy with brain stem and spinal cord involvement and high lactate syndrome
  • Leukoencephalopathy with calcifications and cysts
  • Leukoencephalopathy with metaphyseal chondrodysplasia syndrome
  • Leukoencephalopathy, ataxia, hypodontia, hypomyelination syndrome
  • Leukoencephalopathy, dystonia, motor neuropathy syndrome
  • Leukoencephalopathy, palmoplantar keratoderma syndrome
  • Leukoencephalopathy, thalamus and brainstem anomalies, high lactate syndrome
  • Macroencephaly
  • MECP2-related severe neonatal encephalopathy
  • Megalencephalic leukoencephalopathy with subcortical cysts
  • Multifactorial encephalopathy
  • Neonatal encephalopathy
  • Obstructive sleep apnea syndrome
  • Progressive cavitating leukoencephalopathy
  • Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy syndrome
  • Progressive muscular atrophy
  • Punctate palmoplantar keratoderma
  • PYCR2-related microcephaly, progressive leukoencephalopathy
  • Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
  • SCN2A encephalopathy
  • Second cranial nerve finding
  • Sleep apnea
  • Small vessel cerebrovascular disease
  • Small vessel cerebrovascular disease
  • Small vessel cerebrovascular disease
  • STXBP1 encephalopathy with epilepsy
  • Subcortical dementia
  • Subcortical leukoencephalopathy
  • Subcortical vascular dementia
  • White matter disorder caused by infection
  • White matter disorder co-occurrent and due to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Clinical Classification

Clinical Information

  • Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia|ALSP|HDLS|Hereditary Diffuse Leukoencephalopathy with Spheroids|POLD|Pigmentary Orthochromatic Leukodystrophy

    a rapidly progressive neurodegenerative disorder, caused by mutations in the colony-stimulating factor 1 receptor (csf1r) gene, that presents in adulthood with a variety of neuropsychiatric and motor disturbances. hallmark features include diffuse myelin loss and axonal destruction, neuroaxonal spheroids, and pigmented macrophages and other glia.
  • Grade 1 Leukoencephalopathy, CTCAE|Grade 1 Leukoencephalopathy

    asymptomatic; small focal t2/flair hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (sas) and/or mild ventriculomegaly
  • Grade 2 Leukoencephalopathy, CTCAE|Grade 2 Leukoencephalopathy

    moderate symptoms; focal t2/flair hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in sas and/or moderate ventriculomegaly
  • Grade 2 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE|Grade 2 Reversible posterior leukoencephalopathy syndrome

    moderate symptoms; limiting instrumental adl
  • Grade 3 Leukoencephalopathy, CTCAE|Grade 3 Leukoencephalopathy

    severe symptoms; extensive t2/flair hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in sas and/or moderate to severe ventriculomegaly
  • Grade 3 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE|Grade 3 Reversible posterior leukoencephalopathy syndrome

    severe symptoms; limiting self care adl; hospitalization
  • Grade 4 Leukoencephalopathy, CTCAE|Grade 4 Leukoencephalopathy

    life-threatening consequences; extensive t2/flair hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in sas and/or moderate to severe ventriculomegaly
  • Grade 4 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE|Grade 4 Reversible posterior leukoencephalopathy syndrome

    life-threatening consequences
  • Grade 5 Leukoencephalopathy, CTCAE|Grade 5 Leukoencephalopathy

    death
  • Grade 5 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE|Grade 5 Reversible posterior leukoencephalopathy syndrome

    death
  • Leukoencephalopathy

    white matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
  • Leukoencephalopathy with Ataxia|CC2L|CLCN2-Related Leukoencephalopathy|LKPAT

    an autosomal recessive condition caused by mutation(s) in the clcn2 gene, encoding chloride channel protein 2. it is characterized by variable clinical features including mild cerebellar ataxia, chorioretinopathy, visual field defects, and headaches. a characteristic pattern of white matter abnormalities is evident on mri.
  • Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation|LBSL

    an autosomal recessive condition caused by mutation(s) in the dars2 gene, encoding aspartate--trna ligase, mitochondrial. it is characterized by slowly developing progressive cerebellar ataxia, spasticity, dorsal column dysfunction, and may also include a mild cognitive deficit or decline.
  • Leukoencephalopathy with Vanishing White Matter

    a rare, progressive neurological disorder inherited in an autosomal recessive pattern. it is caused by mutations in the eif2b1, eif2b2, eif2b3, eif2b4, and eif2b5 genes, resulting in deterioration of central nervous system's white matter. usually, there are no signs and symptoms of the disorder at birth. during early childhood, affected individuals develop spasticity and ataxia which may be associated with deterioration of the metal function. examination of the brain at autopsy reveals normal gray matter while the white matter is soft and gelatinous with numerous small cavities.
  • Leukoencephalopathy, CTCAE|Leukoencephalopathy|Leukoencephalopathy

    a disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
  • Progressive Multifocal Leukoencephalopathy|PML

    a progressive demyelination within the central nervous system associated with reactivation of a latent jc virus infection.
  • Reversible Posterior Leukoencephalopathy Syndrome, CTCAE|Reversible Posterior Leukoencephalopathy Syndrome|Reversible posterior leukoencephalopathy syndrome

    a disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. it has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. it is an acute or subacute reversible condition. also known as posterior reversible encephalopathy syndrome (pres).
  • Reversible Posterior Leukoencephalopathy Syndrome|PRES|Posterior Reversible Encephalopathy Syndrome|RPLE|Reversible Occipital Parietal Encephalopathy|Reversible Posterior Cerebral Edema Syndrome|Reversible posterior leukoencephalopathy syndrome

    an acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. it has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment.
  • Obstructive Sleep Apnea Syndrome

    a disorder characterized by recurrent episodic disruptions of breathing during sleep. it is caused by the intermittent relaxation of pharyngeal muscles leading to the narrowing or complete blockage of the upper airway. this results in compensatory arousal from sleep to breathe again. an anatomically narrow airway from body habitus or enlarged pharyngeal structures may also predispose to obstruction. clinical presentation usually includes snoring, daytime sleepiness, difficulty concentrating and fatigue. clinical course may progress to chronic hypoxemia with cardiovascular and cerebrovascular sequelae.
  • Progressive Muscular Atrophy

    a rare, milder form of amyotrophic lateral sclerosis. it is characterized by a slowly progressive clinical course. signs and symptoms include muscle weakness, atrophy, and fasciculation.
  • GAIA Level 1 Neonatal Encephalopathy|Global Alignment of Immunization safety Assessment in pregnancy Level 1 Neonatal Encephalopathy|Level 1 Neonatal Encephalopathy

    gaia level 1 neonatal encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, difficulty with initiating and maintaining respiration; fourth, depression of muscle tone.
  • GAIA Level 2 Neonatal Encephalopathy|Global Alignment of Immunization safety Assessment in pregnancy Level 2 Neonatal Encephalopathy|Level 2 Neonatal Encephalopathy

    gaia level 2 neonatal encephalopathy is defined by three criteria: first, a newborn infant (1 to 28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, either difficulty with initiating and maintaining respiration or depression of muscle tone.
  • GAIA Level 3 Neonatal Encephalopathy|Global Alignment of Immunization safety Assessment in pregnancy Level 3 Neonatal Encephalopathy|Level 3 Neonatal Encephalopathy

    gaia level 3 neonatal encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, none of the following: a) difficulty with initiating or maintaining respiration; b) depression of muscle tone.
  • GAIA Neonatal Encephalopathy Level of Diagnostic Certainty Terminology|Global Alignment of Immunization safety Assessment in pregnancy Neonatal Encephalopathy Level of Diagnostic Certainty

    a subset of terminology related to neonatal encephalopathy, developed by the global alignment of immunization safety assessment in pregnancy consortium to aid in monitoring and improving fetal and maternal outcomes.
  • GAIA Neonatal Encephalopathy Level of Diagnostic Certainty|Global Alignment of Immunization safety Assessment in pregnancy Neonatal Encephalopathy Level of Diagnostic Certainty|Neonatal Encephalopathy Level of Diagnostic Certainty

    a classification of maternal and fetal outcomes relating to neonatal encephalopathy, developed by the global alignment of immunization safety assessment in pregnancy, based on the extent to which the diagnosis has been confirmed.
  • Neonatal Encephalopathy

    abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection.
  • Severe Neonatal Encephalopathy Due to MECP2 Mutations

    an x-linked recessive condition caused by mutation(s) in the mecp2 gene, encoding methyl-cpg-binding protein 2. it is characterized by severe neonatal encephalopathy.

Replaced Code

This code was replaced in the 2024 ICD-10-CM code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2023. This code was replaced for the FY 2024 (October 1, 2023 - September 30, 2024).


  • G93.42 - Megaloencephalic leukoencephalopathy with subcortical cysts
  • G93.43 - Leukoencephalopathy with calcifications and cysts
  • G93.44 - Adult-onset leukodystrophy with axonal spheroids

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Encephalopathy NEC

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert G93.49 to ICD-9-CM

  • ICD-9-CM Code: 348.39 - Encephalopathy NEC
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education


Brain Diseases

Your brain is the control center of your body. It controls your thoughts, memory, speech, and movement. It regulates the function of many organs. It's part of your nervous system, which also includes your spinal cord and peripheral nerves. The nervous system sends signals between your brain and the rest of the body. Your nerves take in information from your senses and send it to the brain to be processed. Your brain and nerves also communicate to help you move and to control your body's functions.

When the brain is healthy, it works quickly and automatically. But when you have a brain disease, it may affect how well you can function and do your daily activities. Some common brain diseases include:

  • Brain tumors, which can press on nerves and affect brain function.
  • Degenerative nerve diseases, which can affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Types include Alzheimer's disease and Parkinson's disease.
  • Encephalitis (inflammation in the brain), which can lead to problems such as vision loss, weakness, and paralysis.
  • Genetic brain disorders, which are caused by changes in genes (also called variants or mutations). These disorders can affect the development and function of the brain.
  • Strokes, which can cause a loss of brain cells and can affect your ability to think clearly.
  • Traumatic brain injuries (TBIs), which can affect brain function. They may range from mild to severe. The effects of a TBI may be temporary or permanent.

The symptoms of brain diseases vary widely, depending on the specific problem. In some cases, damage is permanent. In other cases, treatments such as surgery, medicines, or therapies such as physical, occupational, and speech therapies, may cure the disease or improve the symptoms.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.