2024 ICD-10-CM Diagnosis Code E72.51

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Amino acid above reference range
• Aminomethyltransferase deficiency
• Atypical glycine encephalopathy
• Childhood-onset spasticity with hyperglycinemia
• Glucoglycinuria
• Glycine dehydrogenase deficiency
• Glycosuria
• Hyperglycinemia
• Hyperglycinemia
• Hyperglycinemia
• Hyperglycinemia
• Hyperglycinemia
• Infantile glycine encephalopathy
• Infantile glycine encephalopathy
• Neonatal glycine encephalopathy
• Neonatal metabolic acidemia
• Neonatal metabolic acidemia
• Non-ketotic hyperglycinemia
• Non-ketotic hyperglycinemia
• Non-ketotic hyperglycinemia
• Non-ketotic hyperglycinemia
• Non-ketotic hyperglycinemia
• Non-ketotic hyperglycinemia H protein deficiency
• Non-ketotic hyperglycinemia L protein deficiency
• Transient neonatal hyperglycinemia

Clinical Information

• Glycosuria

  the appearance of an abnormally large amount of glucose in the urine, such as more than 500 mg/day in adults. it can be due to hyperglycemia or genetic defects in renal reabsorption (renal glycosuria).

• Glycosuria, Renal

  an autosomal inherited disorder due to defective reabsorption of glucose by the proximal renal tubules. the urinary loss of glucose can reach beyond 50 g/day. it is attributed to the mutations in the sodium-glucose transporter 2 encoded by the slc5a2 gene.

Convert E72.51 to ICD-9-CM

• ICD-9-CM Code: 270.7 - Straig amin-acid met NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education

Amino Acid Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Your digestive system breaks the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body. If you have a metabolic disorder, something goes wrong with this process.

One group of these disorders is amino acid metabolism disorders. They include phenylketonuria (PKU) and maple syrup urine disease. Amino acids are "building blocks" that join together to form proteins. If you have one of these disorders, your body may have trouble breaking down certain amino acids. Or there may be a problem getting the amino acids into your cells. These problems cause a buildup of harmful substances in your body. That can lead to serious, sometimes life-threatening, health problems.

These disorders are usually inherited. A baby who is born with one may not have any symptoms right away. Because the disorders can be so serious, early diagnosis and treatment are critical. Newborn babies get screened for many of them, using blood tests.

Treatments may include special diets, medicines, and supplements. Some babies may also need additional treatments if there are complications.

[Learn More in MedlinePlus]

Nonketotic hyperglycinemia

Nonketotic hyperglycinemia is a disorder characterized by abnormally high levels of a molecule called glycine in the body (hyperglycinemia). The excess glycine builds up in tissues and organs, particularly the brain. Affected individuals have serious neurological problems.

Nonketotic hyperglycinemia has two forms, the severe form and the attenuated form. Both forms usually begin shortly after birth, although in some cases, signs and symptoms can begin in the first few months of life. Only the attenuated form begins later in infancy. The forms are distinguished by the seriousness of the signs and symptoms. Severe nonketotic hyperglycinemia is more common. Affected babies experience extreme sleepiness (lethargy) that worsens over time and can lead to coma. They can also have weak muscle tone (hypotonia) and life-threatening breathing problems in the first days or weeks of life. Most children who survive these early signs and symptoms develop feeding difficulties, abnormal muscle stiffness (spasticity), profound intellectual disability and seizures that are difficult to control. Most affected children do not achieve normal developmental milestones, such as drinking from a bottle, sitting up, or grabbing objects, and they may lose any acquired skills over time.

The signs and symptoms of the attenuated form of nonketotic hyperglycinemia are similar to, but milder than, those of the severe form of the condition. Children with attenuated nonketotic hyperglycinemia typically reach developmental milestones, although the skills they achieve vary widely. Despite delayed development, many affected children eventually learn to walk and are able to interact with others, often using sign language. Some affected children develop seizures; if present, seizures are usually mild and can be treated. Other features can include spasticity, involuntary jerking movements (chorea), or hyperactivity.

Individuals with nonketotic hyperglycinemia can also have certain changes in the brain, which can be seen using magnetic resonance imaging (MRI). For example, in children with the severe form of the condition, the tissue that connects the left and right halves of the brain (the corpus callosum) is smaller than average.

[Learn More in MedlinePlus]

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.