Version 2024

2024 ICD-10-CM Diagnosis Code C92.5

Acute myelomonocytic leukemia

ICD-10-CM Code:
C92.5
ICD-10 Code for:
Acute myelomonocytic leukemia
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Neoplasms
    (C00–D49)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue
      (C81-C96)
      • Myeloid leukemia
        (C92)

C92.5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of acute myelomonocytic leukemia. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Acute myelomonocytic leukemia

Non-specific codes like C92.5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for acute myelomonocytic leukemia:

  • Use C92.50 for Acute myelomonocytic leukemia, not having achieved remission - BILLABLE CODE

  • Use C92.51 for Acute myelomonocytic leukemia, in remission - BILLABLE CODE

  • Use C92.52 for Acute myelomonocytic leukemia, in relapse - BILLABLE CODE

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • AML M4
  • AML M4 Eo with inv(16) or t(16;16)

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Patient Education


Acute Myeloid Leukemia

What is leukemia?

Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job:

  • White blood cells help your body fight infection
  • Red blood cells deliver oxygen from your lungs to your tissues and organs
  • Platelets help form clots to stop bleeding

When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.

What is acute myeloid leukemia (AML)?

Acute myeloid leukemia (AML) is a type of acute leukemia. "Acute" means that the leukemia usually gets worse quickly if it's not treated. In AML, the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. When the abnormal cells crowd out the healthy cells, it can lead to infection, anemia, and easy bleeding. The abnormal cells can also spread outside the blood to other parts of the body.

There are several different subtypes of AML. The subtypes are based on how developed the cancer cells are when you get your diagnosis and how different they are from normal cells.

What causes acute myeloid leukemia (AML)?

AML happens when there are changes in the genetic material (DNA) in bone marrow cells. The cause of these genetic changes is unknown. However, there are certain factors that raise your risk of AML.

Who is at risk for acute myeloid leukemia (AML)?

The factors that raise your risk of AML include:

  • Being male
  • Smoking, especially after age 60
  • Having had chemotherapy or radiation therapy
  • Treatment for acute lymphoblastic leukemia (ALL) as a child
  • Exposure to the chemical benzene
  • A history of another blood disorder such as myelodysplastic syndrome

What are the symptoms of acute myeloid leukemia (AML)?

The signs and symptoms of AML include:

  • Fever
  • Shortness of breath
  • Easy bruising or bleeding
  • Petechiae, which are tiny red dots under the skin. They are caused by bleeding.
  • Weakness or feeling tired
  • Weight loss or loss of appetite
  • Bone or joint pain, if the abnormal cells build up near or inside the bones

How is acute myeloid leukemia (AML) diagnosed?

Your health care provider may use many tools to diagnose AML and figure out which subtype you have:

  • A physical exam
  • A medical history
  • Blood tests, such as a complete blood count (CBC) and blood smear
  • Bone marrow tests. There are two main types - bone marrow aspiration and bone marrow biopsy. Both tests involve removing a sample of bone marrow and bone. The samples are sent to a lab for testing.
  • Genetic tests to look for gene and chromosome changes

If you are diagnosed with AML, you may have additional tests to see whether the cancer has spread. These include imaging tests and a lumbar puncture, which is a procedure to collect and test cerebrospinal fluid (CSF).

What are the treatments for acute myeloid leukemia (AML)?

Treatments for AML include:

  • Chemotherapy
  • Radiation therapy
  • Chemotherapy with stem cell transplant
  • Other anticancer medicines

Which treatment you get often depends on which subtype of AML you have. Treatment is usually done in two phases:

  • The goal of the first phase is to kill the leukemia cells in the blood and bone marrow. This puts the leukemia into remission. Remission means that the signs and symptoms of cancer are reduced or have disappeared.
  • The second phase is known as post-remission therapy. Its goal is to prevent a relapse (return) of the cancer. It involves killing any remaining leukemia cells that may not be active but could begin to regrow.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Leukemia-Patient Version

Learn about acute myeloid leukemia risk factors, signs and symptoms, tests to diagnose, factors affecting prognosis, and treatment.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.