2024 ICD-10-CM Diagnosis Code C72.9

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Anaplastic astrocytoma of central nervous system
• Anaplastic ependymoma of central nervous system
• Anaplastic ganglioglioma
• Anaplastic ganglioglioma of central nervous system
• Anaplastic oligoastrocytoma of central nervous system
• Anaplastic oligodendroglioma of central nervous system
• Angiocentric glioma of central nervous system
• Astroblastoma of central nervous system
• Choriocarcinoma
• Ependymoblastoma
• Ependymoma of central nervous system
• Fibrillary astrocytoma of central nervous system
• Ganglioneuroblastoma
• Ganglioneuroblastoma
• Ganglioneuroblastoma of central nervous system
• Gemistocytic astrocytoma of central nervous system
• Germinoma of central nervous system
• Giant cell glioblastoma of central nervous system
• Glioblastoma multiforme of central nervous system
• Glioma
• Glioma of central nervous system
• Gliosarcoma of central nervous system
• Malignant glioma of central nervous system
• Malignant neoplasm of central nervous system
• Malignant neoplasm of nervous system
• Medulloepithelioma
• Medulloepithelioma of central nervous system
• Melanoma and neural system tumor syndrome
• Mixed germ cell neoplasm of central nervous system
• Mixed germ cell tumor
• Mixed germ cell tumor
• Mixed glioma
• Mixed glioma
• Neuroblastoma of central nervous system
• Nongerminomatous germ cell tumor of central nervous system
• Overlapping malignant neoplasm of brain and other parts of the central nervous system
• Pilomyxoid astrocytoma
• Primary anaplastic ganglioglioma of central nervous system
• Primary anaplastic oligoastrocytoma of central nervous system
• Primary choriocarcinoma of central nervous system
• Primary ganglioneuroblastoma of central nervous system
• Primary glioblastoma multiforme of central nervous system
• Primary malignant astrocytoma of central nervous system
• Primary malignant atypical teratoid rhabdoid neoplasm of central nervous system
• Primary malignant glioma of central nervous system
• Primary malignant melanoma of central nervous system
• Primary malignant neoplasm of central nervous system
• Primary malignant neoplasm of nervous system
• Primary mixed germ cell neoplasm of central nervous system
• Primary mixed glioma
• Primary neuroblastoma of central nervous system
• Primary primitive neuroectodermal neoplasm of central nervous system
• Primary primitive neuroectodermal tumor
• Yolk sac tumor
• Yolk sac tumor of central nervous system

Clinical Information

• AIDS Arteritis, Central Nervous System

  inflammation of arteries in the central nervous system that occurs in patients with acquired immunodeficiency syndrome or aids-related opportunistic infections.

• Brain Diseases

  pathologic conditions affecting the brain, which is composed of the intracranial components of the central nervous system. this includes (but is not limited to) the cerebral cortex; intracranial white matter; basal ganglia; thalamus; hypothalamus; brain stem; and cerebellum.

• Brain Diseases, Metabolic

  acquired or inborn metabolic diseases that produce brain dysfunction or damage. these include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.

• Brain Diseases, Metabolic, Inborn

  brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. the majority of these conditions are familial, however spontaneous mutation may also occur in utero.

• Central Nervous System

  the main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.

• Central Nervous System Agents

  a class of drugs producing both physiological and psychological effects through a variety of mechanisms. they can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. those with specific mechanisms are classed by locus of action or specific therapeutic use. (from gilman ag, et al., goodman and gilman's the pharmacological basis of therapeutics, 8th ed, p252)

• Central Nervous System Bacterial Infections

  bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.

• Central Nervous System Cysts

  congenital or acquired cysts of the brain, spinal cord, or meninges which may remain stable in size or undergo progressive enlargement.

• Central Nervous System Depressants

  a very loosely defined group of drugs that tend to reduce the activity of the central nervous system. the major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).

• Central Nervous System Diseases

  diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

• Central Nervous System Fungal Infections

  mycoses of the brain, spinal cord, and meninges which may result in encephalitis; meningitis, fungal; myelitis; brain abscess; and epidural abscess. certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., acquired immunodeficiency syndrome).

• Central Nervous System Helminthiasis

  infections of the brain; spinal cord; or meninges caused by helminths (parasitic worms).

• Central Nervous System Infections

  pathogenic infections of the brain, spinal cord, and meninges. dna virus infections; rna virus infections; bacterial infections; mycoplasma infections; spirochaetales infections; fungal infections; protozoan infections; helminthiasis; and prion diseases may involve the central nervous system as a primary or secondary process.

• Central Nervous System Neoplasms

  benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.

• Central Nervous System Parasitic Infections

  infections of the brain, spinal cord, and meninges caused by parasites.

• Central Nervous System Protozoal Infections

  infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. the central nervous system may be the primary or secondary site of protozoal infection. these diseases may occur as opportunistic infections or arise in immunocompetent hosts.

• Central Nervous System Sensitization

  an increased response to stimulation that is mediated by amplification of signaling in the central nervous system (cns).

• Central Nervous System Stimulants

  a loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. they work by a variety of mechanisms, but usually not by direct excitation of neurons. the many drugs that have such actions as side effects to their main therapeutic use are not included here.

• Central Nervous System Vascular Malformations

  congenital, inherited, or acquired abnormalities involving arteries; veins; or venous sinuses in the brain; spinal cord; and meninges.

• Central Nervous System Venous Angioma

  a vascular anomaly characterized by a radial or wedge-shaped arrangement of dilated veins draining into a larger vein in the brain, spinal cord, or the meninges. veins in a venous angioma are surrounded by normal nervous tissue, unlike a central nervous system cavernous hemangioma that lacks intervening nervous tissue. drainage of venous angioma is fully integrated with the body's venous system, therefore, in most cases there is no clinical signs and rare bleeding.

• Central Nervous System Viral Diseases

  viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.

• Cerebral Phaeohyphomycosis

  cns infections caused by neurotropic dematiaceous fungi that contain melanin in their cell walls. the infections often result in brain abscess; encephalitis; and meningitis in patients who are often immunocompetent. the common causative fungi include members cladophialophora bantiana, exophiala dermatitidis, rhinocladiella mackenziei, and ochroconis gallopavum. r. mackenziei infection is seen almost exclusively in patients from the middle east.

• Hemangioma, Cavernous, Central Nervous System

  a vascular anomaly composed of a collection of large, thin walled tortuous veins that can occur in any part of the central nervous system but lack intervening nervous tissue. familial occurrence is common and has been associated with a number of genes mapped to 7q, 7p and 3q. clinical features include seizures; headache; stroke; and progressive neurological deficit.

• Hereditary Central Nervous System Demyelinating Diseases

  inherited conditions characterized by a loss of myelin in the central nervous system.

• Lupus Vasculitis, Central Nervous System

  central nervous system vasculitis that is associated with systemic lupus erythematosus. clinical manifestations may include dementia; seizures; cranial nerve diseases; hemiparesis; blindness; dysphasia; and other neurological disorders.

• Lyme Neuroborreliosis

  nervous system infections caused by tick-borne spirochetes of the borrelia burgdorferi group. the disease may affect elements of the central or peripheral nervous system in isolation or in combination. common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), polyradiculopathy, and a mild loss of memory and other cognitive functions. less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. in the peripheral nervous system, b. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (from j neurol sci 1998 jan 8;153(2):182-91)

• Neurocysticercosis

  infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus taenia (primarily t. solium in humans). lesions formed by the organism are referred to as cysticerci. the infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. seizures represent the most common clinical manifestation although focal neurologic deficits may occur. (from joynt, clinical neurology, 1998, ch27, pp46-50)

• Neuroschistosomiasis

  schistosomiasis of the brain, spinal cord, or meninges caused by infections with trematodes of the genus schistosoma (primarily schistosoma japonicum; schistosoma mansoni; and schistosoma haematobium in humans). s. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. s. mansoni and s. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (from joynt, clinical neurology, 1998, ch27, pp61-2)

• Neurosyphilis

  infections of the central nervous system caused by treponema pallidum which present with a variety of clinical syndromes. the initial phase of infection usually causes a mild or asymptomatic meningeal reaction. the meningovascular form may present acutely as brain infarction. the infection may also remain subclinical for several years. late syndromes include general paresis; tabes dorsalis; meningeal syphilis; syphilitic optic atrophy; and spinal syphilis. general paresis is characterized by progressive dementia; dysarthria; tremor; myoclonus; seizures; and argyll-robertson pupils. (adams et al., principles of neurology, 6th ed, pp722-8)

• Toxoplasmosis, Cerebral

  infections of the brain caused by the protozoan toxoplasma gondii that primarily arise in individuals with immunologic deficiency syndromes (see also aids-related opportunistic infections). the infection may involve the brain diffusely or form discrete abscesses. clinical manifestations include seizures, altered mentation, headache, focal neurologic deficits, and intracranial hypertension. (from joynt, clinical neurology, 1998, ch27, pp41-3)

• Tuberculosis, Central Nervous System

  tuberculosis of the brain, spinal cord, or meninges (tuberculosis, meningeal), most often caused by mycobacterium tuberculosis and rarely by mycobacterium bovis. the infection may be limited to the nervous system or coexist in other organs (e.g., tuberculosis, pulmonary). the organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of tuberculoma, which may occur within the brain, spinal cord, or perimeningeal spaces. tuberculous involvement of the vertebral column (tuberculosis, spinal) may result in nerve root or spinal cord compression. (from adams et al., principles of neurology, 6th ed, pp717-20)

• Vasculitis, Central Nervous System

  inflammation of blood vessels within the central nervous system. primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. clinical manifestations are highly variable but include headache; seizures; behavioral alterations; intracranial hemorrhages; transient ischemic attack; and brain infarction. (from adams et al., principles of neurology, 6th ed, pp856-61)

• Vertigo

  an illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. vertigo may be associated with disorders of the inner ear (ear, inner); vestibular nerve; brainstem; or cerebral cortex. lesions in the temporal lobe and parietal lobe may be associated with focal seizures that may feature vertigo as an ictal manifestation. (from adams et al., principles of neurology, 6th ed, pp300-1)

• Ganglioneuroblastoma

  a moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. it may undergo transformation into a neuroblastoma. it arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. cervical ganglioneuroblastomas may be associated with horner syndrome and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.

• Choriocarcinoma

  a malignant metastatic form of trophoblastic tumors. unlike the hydatidiform mole, choriocarcinoma contains no chorionic villi but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (trophoblasts). it is characterized by the large amounts of chorionic gonadotropin produced. tissue origins can be determined by dna analyses: placental (fetal) origin or non-placental origin (choriocarcinoma, non-gestational).

• Choriocarcinoma, Non-gestational

  a highly malignant choriocarcinoma derived from the non-placental origin such as the totipotent cells in the testis, the ovary, and the pineal gland. it produces high levels of chorionic gonadotropin and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.

• Astrocytoma

  neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades i through iv). in the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (from devita et al., cancer: principles and practice of oncology, 5th ed, pp2013-7; holland et al., cancer medicine, 3d ed, p1082)

• Glioma

  benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). astrocytes may give rise to astrocytomas (astrocytoma) or glioblastoma multiforme (see glioblastoma). oligodendrocytes give rise to oligodendrogliomas (oligodendroglioma) and ependymocytes may undergo transformation to become ependymoma; choroid plexus neoplasms; or colloid cysts of the third ventricle. (from escourolle et al., manual of basic neuropathology, 2nd ed, p21)

• Glioma, Subependymal

  rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. the tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (from clin neurol neurosurg 1997 feb;99(1):17-22)

• Gliosarcoma

  rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. these tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. they may arise in tissue that has been previously irradiated. (from br j neurosurg 1995 apr;9(2):171-8)

• Neoplasms, Neuroepithelial

  neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into neurons, oligodendrocytes, and astrocytes. the majority of craniospinal tumors are of neuroepithelial origin. (from dev biol 1998 aug 1;200(1):1-5)

• Optic Nerve Glioma

  glial cell derived tumors arising from the optic nerve, usually presenting in childhood.

• Retinoblastoma

  a malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. the tumor tends to occur in early childhood or infancy and may be present at birth. the majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. an abnormal pupil reflex (leukokoria); nystagmus, pathologic; strabismus; and visual loss represent common clinical characteristics of this condition. (from devita et al., cancer: principles and practice of oncology, 5th ed, p2104)

• Vascular Endothelial Growth Factor A

  the original member of the family of endothelial cell growth factors referred to as vascular endothelial growth factors. vascular endothelial growth factor-a was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. in addition to stimulating vascular growth and vascular permeability it may play a role in stimulating vasodilation via nitric oxide-dependent pathways. alternative splicing of the mrna for vascular endothelial growth factor a results in several isoforms of the protein being produced.

• Zinc Finger Protein GLI1

  a transcriptional activator and oncogene protein that contains two cys2-his2 zinc fingers. two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the central nervous system; and the gastrointestinal tract. they also regulate sonic hedgehog protein signaling and cell proliferation.

• Zinc Finger Protein Gli3

  a zinc finger transcription factor that contains five cys2-his2 zinc fingers and binds to the gli consensus sequence 5'-gggtggtc-3'. the full-length protein functions as a transcriptional activator whereas the truncated c-terminal form functions as a transcriptional repressor of the sonic hedgehog (shh) signaling pathway; a balance between these two forms is critical for limb and digit development. gli3 also plays a critical role in the differentiation and proliferation of chondrocytes.

• Horner Syndrome

  a syndrome associated with defective sympathetic innervation to one side of the face, including the eye. clinical features include miosis; mild blepharoptosis; and hemifacial anhidrosis (decreased sweating)(see hypohidrosis). lesions of the brain stem; cervical spinal cord; first thoracic nerve root; apex of the lung; carotid artery; cavernous sinus; and apex of the orbit may cause this condition. (from miller et al., clinical neuro-ophthalmology, 4th ed, pp500-11)

Convert C72.9 to ICD-9-CM

• ICD-9-CM Code: 192.8 - Mal neo nervous syst NEC
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.
• ICD-9-CM Code: 192.9 - Mal neo nervous syst NOS
  Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Table of Neoplasms

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Filter table of neoplasms:

Neoplasm, neoplastic	Malignant Primary	Malignant Secondary	CaInSitu	Benign	Uncertain Behavior	Unspecified Behavior
»Neoplasm, neoplastic   »central nervous system	C72.9	C79.40
»Neoplasm, neoplastic   »epidural	C72.9	C79.49		D33.9	D43.9	D49.7
»Neoplasm, neoplastic   »extradural	C72.9	C79.49		D33.9	D43.9	D49.7
»Neoplasm, neoplastic   »motor tract	C72.9	C79.49		D33.9	D43.9	D49.7
»Neoplasm, neoplastic   »nervous system (central)	C72.9	C79.40		D33.9	D43.9	D49.7
»Neoplasm, neoplastic   »parasellar	C72.9	C79.49		D33.9	D43.8	D49.7

Patient Education

Cancer

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, immunotherapy or other types of biologic therapy, or stem cell transplantation.

NIH: National Cancer Institute

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Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.