2024 ICD-10-CM Diagnosis Code B27.81

Other infectious mononucleosis with polyneuropathy

ICD-10-CM Code:
B27.81
ICD-10 Code for:
Other infectious mononucleosis with polyneuropathy
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Certain infectious and parasitic diseases
    (A00–B99)
    • Other viral diseases
      (B25-B34)
      • Infectious mononucleosis
        (B27)

B27.81 is a billable diagnosis code used to specify a medical diagnosis of other infectious mononucleosis with polyneuropathy. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Clinical Classification

Clinical CategoryCCSR Category CodeInpatient Default CCSROutpatient Default CCSR
Other nervous system disorders (neither hereditary nor degenerative)NVS020N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.
PolyneuropathiesNVS015N - Not default inpatient assignment for principal diagnosis or first-listed diagnosis.N - Not default outpatient assignment for principal diagnosis or first-listed diagnosis.
Viral infectionINF008Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Clinical Information

  • Fatigue Syndrome, Chronic

    a syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. there is also considerable overlap between this condition and fibromyalgia. (from semin neurol 1998;18(2):237-42; ann intern med 1994 dec 15;121(12): 953-9)
  • Herpesvirus 4, Human

    the type species of lymphocryptovirus, subfamily gammaherpesvirinae, infecting b-cells in humans. it is thought to be the causative agent of infectious mononucleosis and is strongly associated with oral hairy leukoplakia (leukoplakia, hairy;), burkitt lymphoma; and other malignancies.
  • Infectious Mononucleosis

    a common, acute infection usually caused by the epstein-barr virus (herpesvirus 4, human). there is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.
  • Fibromyalgia

    a common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). muscle pain is typically aggravated by inactivity or exposure to cold. this condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, headaches, and occasionally depression. there is significant overlap between fibromyalgia and the chronic fatigue syndrome (fatigue syndrome, chronic). fibromyalgia may arise as a primary or secondary disease process. it is most frequent in females aged 20 to 50 years. (from adams et al., principles of neurology, 6th ed, p1494-95)

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert B27.81 to ICD-9-CM

  • ICD-9-CM Code: 075 - Infectious mononucleosis
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Patient Education


Infectious Mononucleosis

Infectious mononucleosis, or "mono", is an infection usually caused by the Epstein-Barr virus. The virus spreads through saliva, which is why it's sometimes called "kissing disease." Mono occurs most often in teens and young adults. However, you can get it at any age. Symptoms of mono include:

  • Fever
  • Sore throat
  • Swollen lymph glands

Sometimes you may also have a swollen spleen. Serious problems are rare.

A blood test can show if you have mono. Most people get better in two to four weeks. However, you may feel tired for a few months afterward. Treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.